Protease activated receptors modulate aortic vascular tone
The effect of agonists of the known protease activated receptors (PAR), the thrombin and the PAR-2 receptors, on vasoactive mediator release and vascular tone were studied using rings of rat aorta. Stimulation of aortic rings with the thrombin receptor agonist, Trap-14, or the PAR-2 agonist, SLIGRL,...
Saved in:
Published in | International journal of cardiology Vol. 53; pp. S75 - S80 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ireland Ltd
26.04.1996
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The effect of agonists of the known protease activated receptors (PAR), the thrombin and the PAR-2 receptors, on vasoactive mediator release and vascular tone were studied using rings of rat aorta. Stimulation of aortic rings with the thrombin receptor agonist, Trap-14, or the PAR-2 agonist, SLIGRL, resulted in a rapid release of nitric oxide. Trap-14 and SLIGRL-induced nitric oxide release was reduced by pre-treatment with BQ-788, an ET
B endothelin receptor-specific antagonist. Consistent with a role for endothelin-1 receptor activation in Trap-14 and SLIGRL-induced nitric oxide release, endothelin-1 levels were increased significantly following 5 min treatment of aortic rings with Trap-14 or SLIGRL. Cumulative addition of Trap-14 to aortic rings denuded of endothelium resulted in dose-dependent contraction with an EC
50 value of 23 ± 5 μM, whereas SLIGRL addition failed to induce aortic contraction. These data suggest that the known protease activated receptors are functionally coupled to nitric oxide release. In addition, the thrombin receptor appears to modulate both vasodilator and contractile responses, whereas the PAR-2 receptor is linked only to vasodilation. |
---|---|
AbstractList | The effect of agonists of the known protease activated receptors (PAR), the thrombin and the PAR-2 receptors, on vasoactive mediator release and vascular tone were studied using rings of rat aorta. Stimulation of aortic rings with the thrombin receptor agonist, Trap-14, or the PAR-2 agonist, SLIGRL, resulted in a rapid release of nitric oxide. Trap-14 and SLIGRL-induced nitric oxide release was reduced by pre-treatment with BQ-788, an ET
B endothelin receptor-specific antagonist. Consistent with a role for endothelin-1 receptor activation in Trap-14 and SLIGRL-induced nitric oxide release, endothelin-1 levels were increased significantly following 5 min treatment of aortic rings with Trap-14 or SLIGRL. Cumulative addition of Trap-14 to aortic rings denuded of endothelium resulted in dose-dependent contraction with an EC
50 value of 23 ± 5 μM, whereas SLIGRL addition failed to induce aortic contraction. These data suggest that the known protease activated receptors are functionally coupled to nitric oxide release. In addition, the thrombin receptor appears to modulate both vasodilator and contractile responses, whereas the PAR-2 receptor is linked only to vasodilation. The effect of agonists of the known protease activated receptors (PAR), the thrombin and the PAR-2 receptors, on vasoactive mediator release and vascular tone were studied using rings of rat aorta. Stimulation of aortic rings with the thrombin receptor agonist, Trap-14, or the PAR-2 agonist, SLIGRL, resulted in a rapid release of nitric oxide. Trap-14 and SLIGRL-induced nitric oxide release was reduced by pre-treatment with BQ-788, an ETB endothelin receptor-specific antagonist. Consistent with a role for endothelin-1 receptor activation in Trap-14 and SLIGRL-induced nitric oxide release, endothelin-1 levels were increased significantly following 5 min treatment of aortic rings with Trap-14 or SLIGRL. Cumulative addition of Trap-14 to aortic rings denuded of endothelium resulted in dose-dependent contraction with an EC50 value of 23 +/- 5 microM, whereas SLIGRL addition failed to induce aortic contraction. These data suggest that the known protease activated receptors are functionally coupled to nitric oxide release. In addition, the thrombin receptor appears to modulate both vasodilator and contractile responses, whereas the PAR-2 receptor is linked only to vasodilation. |
Author | Magazine, Harold I. King, Jonathan M. Srivastava, Kamal D. |
Author_xml | – sequence: 1 givenname: Harold I. surname: Magazine fullname: Magazine, Harold I. email: HIMBIOL@QC1.QC.EDU – sequence: 2 givenname: Jonathan M. surname: King fullname: King, Jonathan M. – sequence: 3 givenname: Kamal D. surname: Srivastava fullname: Srivastava, Kamal D. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8793596$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1LAzEQhoMota3-A4U9iR5Wk93NJvEgSPELCnrQc8hOZmFl29QkW_Dfm6WlRw_DMF_vzDwzcrx2ayTkgtFbRll9l0zkvBDltapvaMFrlYsjMmVSVDkTvDom00PLKZmF8E0prZSSEzKRQpVc1VNy_-FdRBMwMxC7rYloM4-Am-h8yFbODn3KZcb52EG2NQFSwmcxnXJGTlrTBzzf-zn5en76XLzmy_eXt8XjMoeSi5hXRsp0h2xraasKORUlNIabopGoKNTM0rLgAjhVhS0tbwG4ZRZUAxIKZss5udrpbrz7GTBEveoCYN-bNbohaCFLqqr00JxUu0bwLgSPrd74bmX8r2ZUj8j0yEOPPLRKwYhMizR2udcfmhXaw9CeUao_7OqYntx26HWADteAtkukorau-3_BH2agfMg |
CitedBy_id | crossref_primary_10_1161_hh1301_092661 crossref_primary_10_1007_s00547_005_2016_z crossref_primary_10_4049_jimmunol_174_11_7320 crossref_primary_10_1124_jpet_102_040352 crossref_primary_10_1002_jnr_10847 crossref_primary_10_1046_j_1365_2141_1999_01356_x crossref_primary_10_1097_00005344_200107000_00012 crossref_primary_10_4196_kjpp_2014_18_6_489 crossref_primary_10_14348_molcells_2014_0167 crossref_primary_10_1038_sj_bjp_0701726 crossref_primary_10_1161_01_CIR_99_19_2590 crossref_primary_10_1540_jsmr_39_249 crossref_primary_10_1016_S0167_5273_98_00035_7 crossref_primary_10_1161_01_RES_81_5_824 crossref_primary_10_1038_sj_bjp_0704714 crossref_primary_10_1038_sj_bjp_0702213 crossref_primary_10_1038_sj_bjp_0704438 crossref_primary_10_1152_physrev_00044_2021 crossref_primary_10_1038_sj_bjp_0703007 crossref_primary_10_1152_physrev_00028_2003 crossref_primary_10_1177_002215549804600204 crossref_primary_10_3109_10520290009064152 crossref_primary_10_1139_y02_125 crossref_primary_10_1111_j_1365_2141_1999_01356_x crossref_primary_10_1016_j_cyto_2003_10_002 crossref_primary_10_1016_j_vph_2005_07_009 crossref_primary_10_4049_jimmunol_161_7_3645 crossref_primary_10_1159_000077044 crossref_primary_10_1002_ddr_10314 crossref_primary_10_1074_jbc_272_17_11133 crossref_primary_10_1161_01_ATV_18_5_825 crossref_primary_10_1152_ajplung_2000_278_1_L193 crossref_primary_10_1016_j_pharmthera_2012_01_007 crossref_primary_10_1242_jcs_00434 |
Cites_doi | 10.1006/bbrc.1993.1685 10.1111/j.1365-2362.1992.tb01828.x 10.1083/jcb.120.6.1491 10.1016/S0021-9258(18)42184-9 10.1016/S0021-9258(17)31872-0 10.1159/000158933 10.1016/0092-8674(91)90261-V 10.1126/science.3961484 |
ContentType | Journal Article |
Copyright | 1996 |
Copyright_xml | – notice: 1996 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/0167-5273(96)02569-7 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1874-1754 |
EndPage | S80 |
ExternalDocumentID | 10_1016_0167_5273_96_02569_7 8793596 0167527396025697 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 0SF 1B1 1P~ 1RT 1~. 1~5 29J 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABFNM ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABXDB ABYKQ ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEB HMK HMO HVGLF HZ~ IHE J1W KOM LCYCR M29 M41 MO0 N9A NCXOZ O-L O9- OA. OAUVE OL~ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SEL SES SEW SPCBC SSH SSZ T5K UV1 WUQ X7M Z5R ZA5 ZGI ~G- AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX ADVLN AFJKZ CITATION 7X8 |
ID | FETCH-LOGICAL-c357t-4a880168f68d44e5073cba5a2b8e90c61d03257c5092d3d5fcc5d1dc9bc8c21d3 |
IEDL.DBID | AIKHN |
ISSN | 0167-5273 |
IngestDate | Fri Aug 16 00:48:43 EDT 2024 Thu Sep 26 18:53:49 EDT 2024 Sat Sep 28 08:37:11 EDT 2024 Fri Feb 23 02:27:23 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Thrombin receptors Protease activated receptors Endothelin Vascular tone Nitric oxide |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c357t-4a880168f68d44e5073cba5a2b8e90c61d03257c5092d3d5fcc5d1dc9bc8c21d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 8793596 |
PQID | 78309479 |
PQPubID | 23479 |
ParticipantIDs | proquest_miscellaneous_78309479 crossref_primary_10_1016_0167_5273_96_02569_7 pubmed_primary_8793596 elsevier_sciencedirect_doi_10_1016_0167_5273_96_02569_7 |
PublicationCentury | 1900 |
PublicationDate | 1996-04-26 |
PublicationDateYYYYMMDD | 1996-04-26 |
PublicationDate_xml | – month: 04 year: 1996 text: 1996-04-26 day: 26 |
PublicationDecade | 1990 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | International journal of cardiology |
PublicationTitleAlternate | Int J Cardiol |
PublicationYear | 1996 |
Publisher | Elsevier Ireland Ltd |
Publisher_xml | – name: Elsevier Ireland Ltd |
References | Tsukahara, Gordienko, Goligorsky (BIB6) 1993; 193 Nystedt, Emilsson, Wahlestedt, Sundelin (BIB2) 1994; 91 Magazine HI, Srivastava KD. Thrombin-induced vascular reactivity is modulated by ET Lum, Andersen, Siflinger-Birnboim (BIB4) 1993; 120 Kohno, Yokokawa, Horio (BIB11) 1992; 29 Vu, Hung, Wheaton, Coughlin (BIB1) 1991; 64 Scarborough, Naughton, Teng (BIB5) 1992; 267 Tsukara, Goligorsky, Ende, Magazine, Bahou (BIB8) 1994; 269 Chester, O'Neil, Allen, Luu, Tadjkarimi, Yacoub (BIB10) 1992; 22 Antonaccio, Normandin, Serafino, Moreland (BIB3) 1993; 266 Merrifield (BIB7) 1986; 232 receptor-coupled nitric oxide release in rat aorta. Am J Physiol, in press. Chester (10.1016/0167-5273(96)02569-7_BIB10) 1992; 22 Merrifield (10.1016/0167-5273(96)02569-7_BIB7) 1986; 232 Kohno (10.1016/0167-5273(96)02569-7_BIB11) 1992; 29 Vu (10.1016/0167-5273(96)02569-7_BIB1) 1991; 64 Tsukahara (10.1016/0167-5273(96)02569-7_BIB6) 1993; 193 10.1016/0167-5273(96)02569-7_BIB9 Nystedt (10.1016/0167-5273(96)02569-7_BIB2) 1994; 91 Antonaccio (10.1016/0167-5273(96)02569-7_BIB3) 1993; 266 Lum (10.1016/0167-5273(96)02569-7_BIB4) 1993; 120 Tsukara (10.1016/0167-5273(96)02569-7_BIB8) 1994; 269 Scarborough (10.1016/0167-5273(96)02569-7_BIB5) 1992; 267 |
References_xml | – volume: 91 start-page: 9208 year: 1994 end-page: 9212 ident: BIB2 article-title: Molecular cloning of a potential proteinase activated receptor publication-title: Proc Natl Acad Sci USA contributor: fullname: Sundelin – volume: 22 start-page: 210 year: 1992 end-page: 213 ident: BIB10 article-title: Effect of endothelin on normal and diseased human coronary arteries publication-title: Eur J Clin Invest contributor: fullname: Yacoub – volume: 267 start-page: 13146 year: 1992 end-page: 13149 ident: BIB5 article-title: Tethered ligand agonist peptides publication-title: J Biol Chem contributor: fullname: Teng – volume: 232 start-page: 341 year: 1986 end-page: 347 ident: BIB7 article-title: Solid-phase peptide synthesis publication-title: Science contributor: fullname: Merrifield – volume: 266 start-page: 125 year: 1993 end-page: 132 ident: BIB3 article-title: Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle publication-title: J Pharmacol Exp Therap contributor: fullname: Moreland – volume: 29 start-page: 56 year: 1992 end-page: 63 ident: BIB11 article-title: Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured red porcine endothelial cells publication-title: J Vasc Res contributor: fullname: Horio – volume: 193 start-page: 722 year: 1993 end-page: 729 ident: BIB6 article-title: Continuous monitoring of nitric oxide release from human umbilical vein endothelial cells publication-title: Biochem Biophys Res Commun contributor: fullname: Goligorsky – volume: 120 start-page: 1491 year: 1993 end-page: 1499 ident: BIB4 article-title: Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization publication-title: J Cell Biol contributor: fullname: Siflinger-Birnboim – volume: 64 start-page: 1057 year: 1991 end-page: 1068 ident: BIB1 article-title: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation publication-title: Cell contributor: fullname: Coughlin – volume: 269 start-page: 21778 year: 1994 end-page: 21785 ident: BIB8 article-title: Molecular and functional characterization of the non-isopeptide-selective ET publication-title: J Biol Chem contributor: fullname: Bahou – volume: 193 start-page: 722 year: 1993 ident: 10.1016/0167-5273(96)02569-7_BIB6 article-title: Continuous monitoring of nitric oxide release from human umbilical vein endothelial cells publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1993.1685 contributor: fullname: Tsukahara – volume: 91 start-page: 9208 year: 1994 ident: 10.1016/0167-5273(96)02569-7_BIB2 article-title: Molecular cloning of a potential proteinase activated receptor contributor: fullname: Nystedt – volume: 266 start-page: 125 year: 1993 ident: 10.1016/0167-5273(96)02569-7_BIB3 article-title: Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle publication-title: J Pharmacol Exp Therap contributor: fullname: Antonaccio – ident: 10.1016/0167-5273(96)02569-7_BIB9 – volume: 22 start-page: 210 year: 1992 ident: 10.1016/0167-5273(96)02569-7_BIB10 article-title: Effect of endothelin on normal and diseased human coronary arteries publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.1992.tb01828.x contributor: fullname: Chester – volume: 120 start-page: 1491 year: 1993 ident: 10.1016/0167-5273(96)02569-7_BIB4 article-title: Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization publication-title: J Cell Biol doi: 10.1083/jcb.120.6.1491 contributor: fullname: Lum – volume: 267 start-page: 13146 year: 1992 ident: 10.1016/0167-5273(96)02569-7_BIB5 article-title: Tethered ligand agonist peptides publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)42184-9 contributor: fullname: Scarborough – volume: 269 start-page: 21778 year: 1994 ident: 10.1016/0167-5273(96)02569-7_BIB8 article-title: Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells: receptor coupling to nitric oxide synthetase publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)31872-0 contributor: fullname: Tsukara – volume: 29 start-page: 56 year: 1992 ident: 10.1016/0167-5273(96)02569-7_BIB11 article-title: Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured red porcine endothelial cells publication-title: J Vasc Res doi: 10.1159/000158933 contributor: fullname: Kohno – volume: 64 start-page: 1057 year: 1991 ident: 10.1016/0167-5273(96)02569-7_BIB1 article-title: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation publication-title: Cell doi: 10.1016/0092-8674(91)90261-V contributor: fullname: Vu – volume: 232 start-page: 341 year: 1986 ident: 10.1016/0167-5273(96)02569-7_BIB7 article-title: Solid-phase peptide synthesis publication-title: Science doi: 10.1126/science.3961484 contributor: fullname: Merrifield |
SSID | ssj0004998 |
Score | 1.6739976 |
Snippet | The effect of agonists of the known protease activated receptors (PAR), the thrombin and the PAR-2 receptors, on vasoactive mediator release and vascular tone... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | S75 |
SubjectTerms | Animals Aorta, Thoracic - physiology Endothelin Male Muscle, Smooth, Vascular - drug effects Nitric oxide Nitric Oxide - metabolism Oligopeptides - pharmacology Peptide Fragments - pharmacology Protease activated receptors Rats Rats, Sprague-Dawley Receptor, Endothelin A Receptor, PAR-2 Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Receptors, Endothelin - physiology Receptors, Thrombin - drug effects Receptors, Thrombin - physiology Thrombin receptors Vascular tone Vasodilation - physiology |
Title | Protease activated receptors modulate aortic vascular tone |
URI | https://dx.doi.org/10.1016/0167-5273(96)02569-7 https://www.ncbi.nlm.nih.gov/pubmed/8793596 https://search.proquest.com/docview/78309479 |
Volume | 53 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JS8NAFH5oC-JFXLEuNQcPehhrklm9laLUlSIWvA2zFTzYFq0e_e2-yeJyKILHTJiXyTcv731h3gJwyDJqJB1lxAnJCBWZJTZlllDKgjLKjziNCc63d7w_pFeP7PFHLkwMq6xsf2nTC2tdjXQqNDvTp6dOjJ-P1cOQgqPbVmIRmuiNKG1As3t53b_7zo5URUfcosJ3nFAn0KW88zV2pPhxIYaIeQ5qHgEtHNHFKqxUDDLplotcg4UwXoel2-qMfAPOBrH0AjqnJOYsvCOX9Am-YpjGvjrJ88THhl14cxIFJHUkahKLcm_C8OL8odcnVYcE4nImZgRxRg_D5YhLT2lAbpc7a5jJrAzq1PHUn-b4TTpkBZnPPRs5x3zqnbJOuiz1-RY0xih-GxJmnUNqw3LkZNSG3AajjDDGS44cytIWkBoWPS0LYeg6QizCqCOMWuFFhFGLFogaO_1rQzXa6j9mHtRQa9T1eIBhxmHy9qqFzPFvVKgWbJU78LUSKWKGMd_590N3YbmMx6Yk43vQmL28hX2kGzPbhsWTj7SNWtW7vxm0K-36BBKE0CQ |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELagSMCCeIryagYGGExJ4icbQlQFWsRAJTbLr0odaCtoGfnt3DVJgaFCYoyTXJzPzt0X-bszIac8Y1axfka9VJwymTnqUu4oYzxqq0NfMExw7j6Kdo_dv_CXH7kwKKssfX_h02feumxplmg2x4NBE_XzWD0MKDiEbS2XyQqSAZR1XXx-yzyA0auqvjdeXqXPpaI5bzvT4nxmhMpF4WkR_ZyFodYm2Sj5Y3JddHGLLMXhNlntlivkO-TqCQsvQGhKMGPhA5hkSOAF4xh31UleRwG364KTIzSQVDrUBEty75Je6_b5pk3L_RGoz7mcUEAZ4otQfaECYxGYXe6d5TZzKupLL9JwmcMX6YETZCEPvO89D2nw2nnlszTke6Q2BPP7JOHOeyA2PAdGxlzMXbTaSmuDEsCgHKsTWsFixkUZDFPpwxBGgzAaDQcIo5F1IivszK_hNOCp_7izUUFtYKbj8oUdxtH03UiVw7-o1HWyV4zAvCdKYn6xOPj3Qxtkrf3c7ZjO3ePDIVkvlNmMZuKI1CZv03gMxGPiTmYz6wtfqM9k |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Protease+activated+receptors+modulate+aortic+vascular+tone&rft.jtitle=International+journal+of+cardiology&rft.au=Magazine%2C+H+I&rft.au=King%2C+J+M&rft.au=Srivastava%2C+K+D&rft.date=1996-04-26&rft.issn=0167-5273&rft.volume=53+Suppl&rft.spage=S75&rft.epage=S80&rft_id=info:doi/10.1016%2F0167-5273%2896%2902569-7&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-5273&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-5273&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-5273&client=summon |