Inhibitors of NLRP3 Inflammasome Formation: A Cardioprotective Role for the Gasotransmitters Carbon Monoxide, Nitric Oxide, and Hydrogen Sulphide in Acute Myocardial Infarction

• Published in: International journal of molecular sciences Vol. 25; no. 17; p. 9247
• Main Authors: Payne, Fergus M., Dabb, Alisha R., Harrison, Joanne C., Sammut, Ivan A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024
• Subjects: Adenosine triphosphate; Animals; Apoptosis; Carbon monoxide; Carbon Monoxide - metabolism; Cardiomyocytes; Cardiotonic Agents - pharmacology; Cardiotonic Agents - therapeutic use; Cell death; Cytokines; Gasotransmitters - metabolism; Heart; Humans; Hydrogen Sulfide - metabolism; Hydrogen Sulfide - pharmacology; Inflammasomes - metabolism; Ischemia; Kinases; Myocardial Infarction - drug therapy; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Reperfusion Injury - drug therapy; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - prevention & control; Nitric oxide; Nitric Oxide - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Proteins; Tumor necrosis factor-TNF; carbon monoxide; NLRP3; nitric oxide; hydrogen sulphide

Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result in myocardial dysfunction, presenting as, myocardial “stunning”, arrhythmias, infarction, and adverse cardiac remodelling, and may lead to bo...