Inhibitors of NLRP3 Inflammasome Formation: A Cardioprotective Role for the Gasotransmitters Carbon Monoxide, Nitric Oxide, and Hydrogen Sulphide in Acute Myocardial Infarction

Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result in myocardial dysfunction, presenting as, myocardial “stunning”, arrhythmias, infarction, and adverse cardiac remodelling, and may lead to bo...

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Published inInternational journal of molecular sciences Vol. 25; no. 17; p. 9247
Main Authors Payne, Fergus M., Dabb, Alisha R., Harrison, Joanne C., Sammut, Ivan A.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.09.2024
Subjects
Adenosine triphosphate
Animals
Apoptosis
Carbon monoxide
Carbon Monoxide - metabolism
Cardiomyocytes
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Cell death
Cytokines
Gasotransmitters - metabolism
Heart
Humans
Hydrogen Sulfide - metabolism
Hydrogen Sulfide - pharmacology
Inflammasomes - metabolism
Ischemia
Kinases
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardial Reperfusion Injury - drug therapy
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - pathology
Myocardial Reperfusion Injury - prevention & control
Nitric oxide
Nitric Oxide - metabolism
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Proteins
Tumor necrosis factor-TNF
carbon monoxide
NLRP3
nitric oxide
hydrogen sulphide
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Abstract Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result in myocardial dysfunction, presenting as, myocardial “stunning”, arrhythmias, infarction, and adverse cardiac remodelling, and may lead to both a systemic and a localised inflammatory response. This localised cardiac inflammatory response is regulated through the nucleotide-binding oligomerisation domain (NACHT), leucine-rich repeat (LRR)-containing protein family pyrin domain (PYD)-3 (NLRP3) inflammasome, a multimeric structure whose components are present within both cardiomyocytes and in cardiac fibroblasts. The NLRP3 inflammasome is activated via numerous danger signals produced by IRI and is central to the resultant innate immune response. Inhibition of this inherent inflammatory response has been shown to protect the myocardium and stop the occurrence of the systemic inflammatory response syndrome following the re-establishment of cardiac circulation. Therapies to prevent NLRP3 inflammasome formation in the clinic are currently lacking, and therefore, new pharmacotherapies are required. This review will highlight the role of the NLRP3 inflammasome within the myocardium during IRI and will examine the therapeutic value of inflammasome inhibition with particular attention to carbon monoxide, nitric oxide, and hydrogen sulphide as potential pharmacological inhibitors of NLRP3 inflammasome activation.
AbstractList Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result in myocardial dysfunction, presenting as, myocardial "stunning", arrhythmias, infarction, and adverse cardiac remodelling, and may lead to both a systemic and a localised inflammatory response. This localised cardiac inflammatory response is regulated through the nucleotide-binding oligomerisation domain (NACHT), leucine-rich repeat (LRR)-containing protein family pyrin domain (PYD)-3 (NLRP3) inflammasome, a multimeric structure whose components are present within both cardiomyocytes and in cardiac fibroblasts. The NLRP3 inflammasome is activated via numerous danger signals produced by IRI and is central to the resultant innate immune response. Inhibition of this inherent inflammatory response has been shown to protect the myocardium and stop the occurrence of the systemic inflammatory response syndrome following the re-establishment of cardiac circulation. Therapies to prevent NLRP3 inflammasome formation in the clinic are currently lacking, and therefore, new pharmacotherapies are required. This review will highlight the role of the NLRP3 inflammasome within the myocardium during IRI and will examine the therapeutic value of inflammasome inhibition with particular attention to carbon monoxide, nitric oxide, and hydrogen sulphide as potential pharmacological inhibitors of NLRP3 inflammasome activation.Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result in myocardial dysfunction, presenting as, myocardial "stunning", arrhythmias, infarction, and adverse cardiac remodelling, and may lead to both a systemic and a localised inflammatory response. This localised cardiac inflammatory response is regulated through the nucleotide-binding oligomerisation domain (NACHT), leucine-rich repeat (LRR)-containing protein family pyrin domain (PYD)-3 (NLRP3) inflammasome, a multimeric structure whose components are present within both cardiomyocytes and in cardiac fibroblasts. The NLRP3 inflammasome is activated via numerous danger signals produced by IRI and is central to the resultant innate immune response. Inhibition of this inherent inflammatory response has been shown to protect the myocardium and stop the occurrence of the systemic inflammatory response syndrome following the re-establishment of cardiac circulation. Therapies to prevent NLRP3 inflammasome formation in the clinic are currently lacking, and therefore, new pharmacotherapies are required. This review will highlight the role of the NLRP3 inflammasome within the myocardium during IRI and will examine the therapeutic value of inflammasome inhibition with particular attention to carbon monoxide, nitric oxide, and hydrogen sulphide as potential pharmacological inhibitors of NLRP3 inflammasome activation.
Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result in myocardial dysfunction, presenting as, myocardial “stunning”, arrhythmias, infarction, and adverse cardiac remodelling, and may lead to both a systemic and a localised inflammatory response. This localised cardiac inflammatory response is regulated through the nucleotide-binding oligomerisation domain (NACHT), leucine-rich repeat (LRR)-containing protein family pyrin domain (PYD)-3 (NLRP3) inflammasome, a multimeric structure whose components are present within both cardiomyocytes and in cardiac fibroblasts. The NLRP3 inflammasome is activated via numerous danger signals produced by IRI and is central to the resultant innate immune response. Inhibition of this inherent inflammatory response has been shown to protect the myocardium and stop the occurrence of the systemic inflammatory response syndrome following the re-establishment of cardiac circulation. Therapies to prevent NLRP3 inflammasome formation in the clinic are currently lacking, and therefore, new pharmacotherapies are required. This review will highlight the role of the NLRP3 inflammasome within the myocardium during IRI and will examine the therapeutic value of inflammasome inhibition with particular attention to carbon monoxide, nitric oxide, and hydrogen sulphide as potential pharmacological inhibitors of NLRP3 inflammasome activation.
Author Sammut, Ivan A.
Harrison, Joanne C.
Payne, Fergus M.
Dabb, Alisha R.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/39273196$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0021-9258(18)63477-5
10.1016/j.jtcvs.2018.08.117
10.1016/j.hlc.2017.09.006
10.1089/ars.2015.6615
10.1093/cvr/cvu259
10.1084/jem.20060845
10.1038/sj.cdd.4402194
10.1016/j.ejphar.2017.10.031
10.1161/01.HYP.32.5.856
10.1038/nature16959
10.1111/j.1476-5381.2009.00354.x
10.1371/journal.pone.0007059
10.1089/ars.2012.4645
10.1038/ni.2474
10.1016/j.jss.2020.07.022
10.1016/j.yexcr.2017.11.015
10.1155/2015/691070
10.1016/j.vph.2010.04.002
10.1111/bph.12806
10.1016/j.ejphar.2014.01.009
10.1007/s00011-015-0834-9
10.1186/s12974-018-1077-9
10.12659/MSM.908529
10.1016/j.redox.2018.10.023
10.4049/jimmunol.1301681
10.3892/etm.2015.2218
10.1073/pnas.93.2.795
10.1038/356768a0
10.1096/fj.04-2279fje
10.1089/ars.2008.2132
10.1093/cvr/cvx049
10.2459/JCM.0000000000000435
10.1016/0891-5849(96)02060-6
10.1161/01.CIR.89.5.2035
10.1084/jem.185.4.601
10.1016/j.bbrc.2015.12.051
10.1161/JAHA.116.004160
10.1007/s00011-016-0973-7
10.1161/01.RES.55.6.816
10.21037/jtd.2016.10.106
10.1038/cr.2013.6
10.1111/jpi.12414
10.1007/s11302-010-9213-8
10.1038/nature08938
10.1073/pnas.1100667108
10.1016/j.exer.2006.03.009
10.1038/nm.3806
10.1164/ajrccm.159.1.9806024
10.1038/ng756
10.1371/journal.pone.0108844
10.1038/s41590-022-01185-3
10.1161/01.RES.78.3.482
10.3389/fphys.2015.00058
10.1016/j.gene.2013.05.041
10.1016/j.febslet.2012.02.045
10.4049/jimmunol.1402658
10.1177/0267659111420607
10.1084/jem.192.7.1015
10.1093/cvr/cvv097
10.1177/1535370219899899
10.1016/j.biocel.2007.01.013
10.1007/s11010-016-2849-0
10.1155/2016/5271251
10.1007/s00395-017-0603-8
10.3109/00365514909069943
10.1016/j.freeradbiomed.2017.06.016
10.1523/JNEUROSCI.4088-10.2010
10.1016/0891-5849(95)00081-8
10.1093/cvr/24.11.873
10.1155/2020/9219825
10.1161/01.RES.49.4.892
10.1038/377239a0
10.1007/s00395-005-0569-9
10.1016/j.redox.2018.02.019
10.1039/D0NR07484E
10.1111/1755-5922.12128
10.1161/hh0202.104530
10.1152/ajplung.2000.278.2.L312
10.1042/bj2240591
10.1016/j.jacc.2018.11.053
10.1038/nature15514
10.1161/01.RES.60.2.185
10.1056/NEJMra071667
10.2337/db14-1668
10.1161/CIRCRESAHA.109.199919
10.1016/j.ebiom.2018.12.059
10.1101/gad.13.1.76
10.1007/s00395-014-0415-z
10.1016/j.yjmcc.2004.04.009
10.3389/fcell.2020.00167
10.1242/bio.043653
10.1016/j.ejmech.2023.115542
10.1038/s41586-018-0372-z
10.1111/j.1742-7843.2012.00856.x
10.1161/CIRCULATIONAHA.110.982777
10.1016/j.celrep.2016.06.103
10.1152/ajpheart.1994.267.4.H1353
10.1113/expphysiol.2012.068338
10.1002/anie.201305876
10.1016/S0021-9258(18)47024-X
10.1038/ni.1638
10.15252/embr.201438463
10.1042/bj2740611
10.15252/embj.201694696
10.1073/pnas.0703725104
10.1038/nrcardio.2014.28
10.1096/fj.04-2169fje
10.1111/j.1749-6632.1970.tb49799.x
10.1038/jcbfm.1995.97
10.1016/j.mvr.2013.09.002
10.1038/ni.1831
10.1177/1074248420923542
10.3389/fphys.2013.00228
10.1152/ajpheart.00574.2014
10.1016/j.biocel.2013.02.009
10.1093/rheumatology/36.6.651
10.1096/fj.06-6270fje
10.1016/j.molcel.2012.11.009
10.1111/febs.15133
10.1038/327524a0
10.1152/ajpheart.00683.2005
10.1093/cvr/cvw037
10.1152/ajplung.00400.2014
10.1016/0016-5085(95)90341-0
10.1038/35055104
10.1016/j.immuni.2022.06.007
10.1002/ajoc.202200350
10.1074/jbc.M112.407130
10.1038/ni.2639
10.1093/emboj/20.21.6008
10.1073/pnas.1108586108
10.1159/000453208
10.1038/s42003-023-04817-y
10.1371/journal.pone.0040643
10.1161/CIRCRESAHA.107.154781
10.1038/ncomms2339
10.4049/jimmunol.1302839
10.1038/s41589-019-0277-7
10.1016/0014-5793(94)00722-5
10.3390/ijms22115737
10.1073/pnas.1716095115
10.1089/ars.2015.6331
10.1016/j.bcp.2023.115642
10.1016/j.bbadis.2017.10.001
10.1042/bj2060267
10.1038/ni.3333
10.4049/jimmunol.164.10.5120
10.1161/01.CIR.69.2.250
10.1038/ncomms10555
10.1016/j.abb.2018.11.013
10.1038/s41589-019-0278-6
10.1074/jbc.M112.381228
10.1038/nature09663
10.1038/nature18590
10.1074/jbc.M302942200
10.1093/cvr/cvt091
10.14814/phy2.15974
10.1097/CCM.0b013e3182a27909
10.1016/j.yjmcc.2008.01.007
10.1038/74680
10.1016/S0006-8993(03)02761-6
10.1016/j.freeradbiomed.2003.12.016
10.4049/jimmunol.0900173
10.1016/j.intimp.2019.04.022
10.1007/s10495-006-6305-6
10.1016/j.brainres.2012.10.046
10.1016/S0021-9258(20)64313-7
10.1038/347768a0
10.1038/s41586-022-05570-8
10.1161/01.RES.66.6.1561
10.1152/ajpheart.00023.2006
10.1152/ajpheart.1996.271.3.H876
10.1016/j.ejphar.2019.172636
10.1016/j.biopha.2020.110990
10.1016/j.immuni.2006.02.004
10.4049/jimmunol.0901363
10.1038/sj.bjp.0702212
10.1073/pnas.0505136102
10.1097/FJC.0000000000000658
10.1016/j.ejphar.2009.01.041
10.1161/01.RES.68.5.1250
10.1097/FJC.0000000000000931
10.2337/db16-0020
10.1152/ajpcell.00195.2008
10.1016/j.bbadis.2018.05.023
10.1126/science.281.5381.1309
10.4049/jimmunol.0900138
10.1073/pnas.96.2.657
10.1016/j.jtcvs.2002.08.001
10.1016/j.bbamcr.2014.11.012
10.1136/gut.36.5.718
10.1021/acs.chemrev.7b00205
10.1074/jbc.M108317200
10.1073/pnas.88.11.4651
10.4049/jimmunol.166.6.3873
10.33549/physiolres.934928
10.4049/jimmunol.1202479
10.1159/000495593
10.1097/01.shk.0000225722.56681.64
10.1039/C7SC01647F
10.1074/jbc.M601078200
10.1074/jbc.M808824200
10.1007/s11239-019-02026-1
10.1155/2017/9743280
10.1096/fj.08-122804
10.1016/S0140-6736(87)91481-4
10.1161/hh1401.093314
10.1016/j.bbrc.2007.05.063
10.1093/cvr/cvn140
10.1007/s00395-017-0664-8
10.1161/01.RES.0000084381.86567.08
10.1186/s12974-017-0940-4
10.1039/D3SC00411B
10.1016/j.biochi.2015.03.009
10.1111/j.1432-1033.1997.00725.x
10.1073/pnas.0705891104
10.1007/s003950170032
10.1074/jbc.M109.082305
10.1016/j.ijcard.2016.02.043
10.4049/jimmunol.1100613
10.1016/j.hlc.2010.02.021
10.1038/nature04515
10.1016/j.molimm.2011.05.014
10.1196/annals.1397.029
10.1073/pnas.92.7.2568
10.1016/j.ijcard.2014.09.148
10.1111/j.1600-6143.2004.00695.x
10.1161/01.RES.65.4.1045
10.1097/SHK.0000000000001175
10.1161/CIRCHEARTFAILURE.109.931451
10.1042/BJ20121198
10.1021/acs.orglett.5b01962
10.3892/mmr.2021.12157
10.1038/sj.emboj.7601521
10.1097/SHK.0b013e318180ff89
10.1097/HJH.0000000000002101
10.1038/333664a0
10.1152/jappl.1957.10.2.186
10.1016/S0021-9258(17)42488-4
10.1093/jat/13.2.105
10.1111/j.1476-5381.2012.02187.x
10.1152/ajpheart.01111.2007
10.1074/jbc.M408092200
10.1073/pnas.93.8.3308
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OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ijms25179247
PMID 39273196
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crossref_citationtrail_10_3390_ijms25179247
crossref_primary_10_3390_ijms25179247
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  text: 2024-09-01
  day: 01
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PublicationTitle International journal of molecular sciences
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References Qiao (ref_54) 2012; 586
Kim (ref_15) 1987; 60
Wilkinson (ref_133) 2009; 158
Jung (ref_137) 2015; 308
Hill (ref_197) 1984; 224
Kawaguchi (ref_32) 2011; 123
Bai (ref_79) 2018; 362
Westermann (ref_35) 2011; 4
Zhang (ref_56) 2018; 51
Zhong (ref_74) 2018; 560
Petrache (ref_129) 2000; 278
Proell (ref_43) 2013; 449
ref_246
Murphy (ref_16) 1991; 68
Polhemus (ref_201) 2015; 33
Stupfel (ref_110) 1970; 174
Lohninger (ref_223) 2015; 112
ref_120
ref_242
Katsnelson (ref_70) 2015; 194
Guo (ref_224) 2014; 725
Bracey (ref_39) 2013; 98
Yin (ref_218) 2013; 1491
Tenhunen (ref_101) 1969; 244
Green (ref_25) 1998; 281
Rossol (ref_71) 2012; 3
Huang (ref_238) 2016; 40
Mastrocola (ref_97) 2016; 2016
Chen (ref_66) 2015; 1853
Bell (ref_121) 2022; 11
Hollmann (ref_248) 2014; 177
Correa (ref_19) 2007; 39
Gan (ref_233) 2018; 1864
Walev (ref_69) 2000; 164
Sivarajah (ref_203) 2009; 31
Vajjhala (ref_42) 2012; 287
Khandoudi (ref_14) 1990; 24
Elrod (ref_220) 2007; 104
Tani (ref_18) 1996; 271
ref_78
ref_77
Ma (ref_172) 2007; 26
Zhang (ref_230) 2014; 53
Nakao (ref_107) 2005; 5
Yang (ref_229) 2013; 18
Chen (ref_141) 2018; 15
Mariathasan (ref_51) 2006; 440
Allen (ref_99) 1957; 10
Xu (ref_150) 1999; 96
Griscavage (ref_159) 1996; 93
Pisarenko (ref_166) 2021; 257
Liu (ref_62) 2017; 63
Ishigami (ref_192) 2009; 11
Liu (ref_139) 2014; 109
Palmer (ref_146) 1987; 327
Billingham (ref_75) 2022; 23
Ariyaratnam (ref_217) 2013; 90
Yellon (ref_67) 2007; 357
Venkatachalam (ref_72) 2009; 284
Brouard (ref_128) 2002; 277
Zhao (ref_235) 2017; 14
Sun (ref_189) 2016; 110
Shi (ref_83) 2015; 526
Juliana (ref_48) 2012; 287
Jha (ref_81) 2010; 30
Alizadeh (ref_80) 2006; 83
Kurihara (ref_157) 1998; 32
Bauer (ref_119) 2023; 14
Becker (ref_29) 2020; 49
Maines (ref_102) 1986; 261
Xie (ref_209) 2016; 24
Karwi (ref_204) 2018; 113
Zhang (ref_125) 2005; 280
Jiang (ref_138) 2016; 65
Clark (ref_114) 2003; 93
Connelly (ref_160) 2001; 166
Cao (ref_36) 2019; 51
Sivarajah (ref_219) 2006; 26
ref_205
Ruggieri (ref_2) 2018; 27
Xu (ref_27) 2019; 20
Gastaldi (ref_95) 2023; 257
Lei (ref_86) 2018; 24
Jha (ref_64) 2020; 287
Franchi (ref_53) 2009; 183
Itoh (ref_228) 1999; 13
Rachmilewitz (ref_177) 1995; 36
Bredt (ref_155) 1990; 347
Lakkisto (ref_108) 2018; 818
ref_239
Baudino (ref_61) 2006; 291
Radi (ref_167) 1991; 266
Lin (ref_231) 2018; 1864
Karmakar (ref_135) 2016; 7
Motterlini (ref_113) 2005; 19
Liu (ref_243) 2017; 26
Janier (ref_9) 1994; 267
Shi (ref_44) 2016; 17
Pagliaro (ref_8) 2017; 18
Mezzaroma (ref_37) 2011; 108
Zhou (ref_52) 2011; 469
White (ref_216) 2013; 168
Wilkinson (ref_136) 2011; 7
Wilson (ref_6) 2010; 19
Ding (ref_73) 2013; 527
Morse (ref_130) 2003; 278
Martin (ref_173) 2006; 281
Otterbein (ref_124) 2000; 6
Duewell (ref_232) 2010; 464
Hung (ref_162) 2004; 36
Kharitonov (ref_123) 1995; 92
Chen (ref_134) 2013; 45
Cserepes (ref_105) 2007; 1095
Ishida (ref_168) 1996; 20
Gianetti (ref_190) 2004; 127
Desmard (ref_118) 2009; 23
Bauernfeind (ref_57) 2011; 187
Kang (ref_63) 2013; 191
Zheng (ref_144) 2019; 40
Juliana (ref_184) 2010; 285
Meng (ref_207) 2015; 2015
Cross (ref_11) 1996; 78
Sheedy (ref_234) 2013; 14
Bertinaria (ref_96) 2019; 670
Xian (ref_76) 2022; 55
Zhang (ref_145) 2017; 112
Sutterwala (ref_46) 2006; 24
Bigger (ref_17) 1984; 69
Ding (ref_84) 2016; 535
Qiu (ref_240) 2017; 2017
Allam (ref_60) 2014; 15
Goodwin (ref_191) 1989; 13
Yang (ref_164) 2021; 13
ref_23
Calvert (ref_226) 2009; 105
Tsuchiya (ref_181) 2012; 189
Gao (ref_91) 2019; 74
Elliott (ref_171) 1995; 109
Zhou (ref_140) 2010; 11
Raja (ref_3) 2016; 8
Hirai (ref_31) 2003; 9
Soni (ref_116) 2010; 53
Sandanger (ref_34) 2013; 99
Ermolaeva (ref_55) 2008; 9
Suleiman (ref_5) 2011; 26
Rai (ref_30) 2017; 424
Kuo (ref_215) 2016; 310
Xiao (ref_45) 2023; 613
Yusof (ref_222) 2009; 296
Nakahira (ref_131) 2006; 203
Portal (ref_115) 2019; 862
Adhikari (ref_165) 2014; 42
Tripatara (ref_194) 2009; 606
Liang (ref_198) 2015; 17
(ref_100) 1949; 1
Bauernfeind (ref_49) 2009; 183
Wang (ref_158) 1995; 15
Kamenshchikov (ref_188) 2019; 157
Papapetropoulos (ref_200) 2015; 172
Marchetti (ref_92) 2018; 115
Hausenloy (ref_7) 2017; 113
Mccoubrey (ref_103) 1997; 247
Zhu (ref_28) 2018; 16
Arostegui (ref_90) 2019; 15
Hoffman (ref_41) 2001; 29
Mao (ref_182) 2013; 23
Niedbala (ref_179) 2007; 104
Motterlini (ref_112) 2002; 90
Zhao (ref_210) 2001; 20
Py (ref_50) 2013; 49
Grabowski (ref_175) 1997; 36
Yong (ref_213) 2008; 44
Czapski (ref_163) 1995; 19
Neely (ref_12) 1984; 55
Johansen (ref_206) 2006; 101
Goldbaum (ref_109) 1976; 6
Lim (ref_212) 2008; 295
Wohlford (ref_94) 2021; 77
Ishide (ref_156) 2003; 977
Kim (ref_26) 2006; 290
Balligand (ref_148) 1994; 269
He (ref_68) 2016; 530
ref_174
Jennings (ref_21) 1978; 92
Stamler (ref_154) 1994; 89
Asanuma (ref_187) 2001; 96
Penna (ref_98) 2020; 2020
Sun (ref_214) 2008; 79
Kubes (ref_152) 1991; 88
Liu (ref_225) 2015; 9
Winburn (ref_117) 2012; 111
Thornberry (ref_82) 1992; 356
Sato (ref_161) 2005; 102
Payne (ref_122) 2024; 12
Meng (ref_208) 2016; 5
Sandanger (ref_247) 2016; 469
Willingham (ref_40) 2009; 183
Brouard (ref_127) 2000; 192
Lee (ref_178) 2015; 64
Yang (ref_221) 2004; 18
ref_65
Seidlmayer (ref_24) 2015; 106
Chung (ref_142) 2011; 48
Jaffrey (ref_183) 2001; 3
Radomski (ref_153) 1987; 330
Toldo (ref_93) 2019; 73
Kim (ref_143) 2007; 101
Sammut (ref_126) 1998; 125
Qin (ref_132) 2015; 64
Tian (ref_236) 2017; 110
Hinder (ref_176) 1999; 159
Lee (ref_211) 2007; 358
Li (ref_170) 2006; 11
Zhang (ref_59) 2016; 16
Coll (ref_88) 2015; 21
Frangogiannis (ref_33) 2014; 11
Stipanuk (ref_193) 1982; 206
Kelm (ref_151) 1990; 66
Gurung (ref_58) 2014; 192
ref_196
Jennings (ref_10) 1981; 49
Nguyen (ref_202) 2020; 25
Zakhary (ref_104) 1996; 93
Toldo (ref_38) 2016; 209
Huang (ref_149) 1995; 377
Wu (ref_87) 2007; 14
Doenst (ref_1) 2019; 73
Niedbala (ref_180) 2011; 108
Kueh (ref_111) 2017; 8
Li (ref_244) 2019; 37
Yet (ref_106) 2001; 89
Xie (ref_227) 2016; 65
Dimmeler (ref_185) 1997; 185
Zanardo (ref_199) 2006; 20
Palmer (ref_147) 1988; 333
Xia (ref_241) 2023; 72
Griffiths (ref_20) 1991; 274
Singh (ref_22) 2004; 37
Jia (ref_237) 2020; 245
Su (ref_245) 2021; 24
Sborgi (ref_85) 2016; 35
Coll (ref_89) 2019; 15
Tani (ref_13) 1989; 65
Kaur (ref_169) 1994; 350
ref_4
Filipovic (ref_195) 2018; 118
Toldo (ref_47) 2015; 105
Mishra (ref_186) 2013; 14
References_xml – volume: 244
  start-page: 6388
  year: 1969
  ident: ref_101
  article-title: Microsomal heme oxygenase: Characterization of the enzyme
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)63477-5
– volume: 157
  start-page: 2328
  year: 2019
  ident: ref_188
  article-title: Nitric oxide provides myocardial protection when added to the cardiopulmonary bypass circuit during cardiac surgery: Randomized trial
  publication-title: J. Thorac. Cardiovasc. Surg.
  doi: 10.1016/j.jtcvs.2018.08.117
– volume: 27
  start-page: 1476
  year: 2018
  ident: ref_2
  article-title: Prognostic impact of prolonged cross-clamp time in coronary artery bypass grafting
  publication-title: Heart Lung Circ.
  doi: 10.1016/j.hlc.2017.09.006
– volume: 26
  start-page: 28
  year: 2017
  ident: ref_243
  article-title: Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2015.6615
– volume: 105
  start-page: 203
  year: 2015
  ident: ref_47
  article-title: Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvu259
– volume: 92
  start-page: 187
  year: 1978
  ident: ref_21
  article-title: Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog
  publication-title: Am. J. Pathol.
– volume: 203
  start-page: 2377
  year: 2006
  ident: ref_131
  article-title: Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20060845
– volume: 14
  start-page: 1590
  year: 2007
  ident: ref_87
  article-title: The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4402194
– volume: 818
  start-page: 57
  year: 2018
  ident: ref_108
  article-title: Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2017.10.031
– volume: 32
  start-page: 856
  year: 1998
  ident: ref_157
  article-title: Role of nNOS in blood pressure regulation in eNOS null mutant mice
  publication-title: Hypertension
  doi: 10.1161/01.HYP.32.5.856
– volume: 530
  start-page: 354
  year: 2016
  ident: ref_68
  article-title: NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
  publication-title: Nature
  doi: 10.1038/nature16959
– volume: 158
  start-page: 862
  year: 2009
  ident: ref_133
  article-title: Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.2009.00354.x
– ident: ref_174
  doi: 10.1371/journal.pone.0007059
– volume: 18
  start-page: 1906
  year: 2013
  ident: ref_229
  article-title: Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.4645
– volume: 14
  start-page: 52
  year: 2013
  ident: ref_186
  article-title: Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2474
– volume: 257
  start-page: 178
  year: 2021
  ident: ref_166
  article-title: Modulating the Bioactivity of Nitric Oxide as a Therapeutic Strategy in Cardiac Surgery
  publication-title: J. Surg. Res.
  doi: 10.1016/j.jss.2020.07.022
– volume: 362
  start-page: 180
  year: 2018
  ident: ref_79
  article-title: Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2017.11.015
– volume: 2015
  start-page: 691070
  year: 2015
  ident: ref_207
  article-title: Hydrogen sulfide donor GYY4137 protects against myocardial fibrosis
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2015/691070
– volume: 53
  start-page: 68
  year: 2010
  ident: ref_116
  article-title: Cardioprotective effect with carbon monoxide releasing molecule-2 (CORM-2) in isolated perfused rat heart: Role of coronary endothelium and underlying mechanism
  publication-title: Vasc. Pharmacol.
  doi: 10.1016/j.vph.2010.04.002
– volume: 172
  start-page: 1633
  year: 2015
  ident: ref_200
  article-title: Pharmacological tools for hydrogen sulphide research: A brief, introductory guide for beginners
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.12806
– volume: 725
  start-page: 70
  year: 2014
  ident: ref_224
  article-title: Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2014.01.009
– volume: 64
  start-page: 537
  year: 2015
  ident: ref_132
  article-title: Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-015-0834-9
– volume: 15
  start-page: 32
  year: 2018
  ident: ref_141
  article-title: IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-018-1077-9
– volume: 24
  start-page: 6044
  year: 2018
  ident: ref_86
  article-title: NF-κB-Gasdermin D (GSDMD) axis couples oxidative stress and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis following myocardial infarction
  publication-title: Med. Sci. Monit.
  doi: 10.12659/MSM.908529
– volume: 20
  start-page: 414
  year: 2019
  ident: ref_27
  article-title: ARC regulates programmed necrosis and myocardial ischemia/reperfusion injury through the inhibition of mPTP opening
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2018.10.023
– volume: 191
  start-page: 3995
  year: 2013
  ident: ref_63
  article-title: Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1301681
– volume: 9
  start-page: 1068
  year: 2015
  ident: ref_225
  article-title: Effect of hydrogen sulfide on inflammatory cytokines in acute myocardial ischemia injury in rats
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2015.2218
– volume: 93
  start-page: 795
  year: 1996
  ident: ref_104
  article-title: Heme oxygenase 2: Endothelial and neuronal localization and role in endothelium-dependent relaxation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.93.2.795
– volume: 356
  start-page: 768
  year: 1992
  ident: ref_82
  article-title: A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
  publication-title: Nature
  doi: 10.1038/356768a0
– volume: 18
  start-page: 1782
  year: 2004
  ident: ref_221
  article-title: Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3
  publication-title: FASEB J.
  doi: 10.1096/fj.04-2279fje
– volume: 11
  start-page: 205
  year: 2009
  ident: ref_192
  article-title: A source of hydrogen sulfide and a mechanism of its release in the brain
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2008.2132
– volume: 113
  start-page: 564
  year: 2017
  ident: ref_7
  article-title: Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvx049
– volume: 18
  start-page: 131
  year: 2017
  ident: ref_8
  article-title: Hypertension, hypertrophy, and reperfusion injury
  publication-title: J. Cardiovasc. Med.
  doi: 10.2459/JCM.0000000000000435
– volume: 20
  start-page: 343
  year: 1996
  ident: ref_168
  article-title: Peroxynitrite-induced cardiac myocyte injury
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/0891-5849(96)02060-6
– ident: ref_196
– volume: 89
  start-page: 2035
  year: 1994
  ident: ref_154
  article-title: Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans
  publication-title: Circulation
  doi: 10.1161/01.CIR.89.5.2035
– volume: 185
  start-page: 601
  year: 1997
  ident: ref_185
  article-title: Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β–converting enzyme (ice)-like and cysteine protease protein (cpp)-32–like proteases
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.185.4.601
– volume: 469
  start-page: 1012
  year: 2016
  ident: ref_247
  article-title: NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2015.12.051
– volume: 5
  start-page: e004160
  year: 2016
  ident: ref_208
  article-title: Hydrogen sulfide regulates Krüppel-like factor 5 transcription activity via specificity protein 1 S-sulfhydration at Cys664 to prevent myocardial hypertrophy
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.116.004160
– volume: 65
  start-page: 905
  year: 2016
  ident: ref_138
  article-title: CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury
  publication-title: Inflamm. Res.
  doi: 10.1007/s00011-016-0973-7
– volume: 55
  start-page: 816
  year: 1984
  ident: ref_12
  article-title: Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.55.6.816
– volume: 8
  start-page: S799
  year: 2016
  ident: ref_3
  article-title: Off-pump coronary artery bypass grafting in octogenarians
  publication-title: J. Thorac. Dis.
  doi: 10.21037/jtd.2016.10.106
– volume: 23
  start-page: 201
  year: 2013
  ident: ref_182
  article-title: Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
  publication-title: Cell Res.
  doi: 10.1038/cr.2013.6
– volume: 63
  start-page: e12414
  year: 2017
  ident: ref_62
  article-title: Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue
  publication-title: J. Pineal Res.
  doi: 10.1111/jpi.12414
– volume: 7
  start-page: 57
  year: 2011
  ident: ref_136
  article-title: The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors
  publication-title: Purinergic Signal.
  doi: 10.1007/s11302-010-9213-8
– volume: 464
  start-page: 1357
  year: 2010
  ident: ref_232
  article-title: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
  publication-title: Nature
  doi: 10.1038/nature08938
– volume: 108
  start-page: 9220
  year: 2011
  ident: ref_180
  article-title: Regulation of type 17 helper T-cell function by nitric oxide during inflammation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1100667108
– volume: 83
  start-page: 679
  year: 2006
  ident: ref_80
  article-title: Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium/choroid of the mouse
  publication-title: Exp. Eye Res.
  doi: 10.1016/j.exer.2006.03.009
– volume: 21
  start-page: 248
  year: 2015
  ident: ref_88
  article-title: A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
  publication-title: Nat. Med.
  doi: 10.1038/nm.3806
– volume: 159
  start-page: 252
  year: 1999
  ident: ref_176
  article-title: Role of nitric oxide in sepsis-associated pulmonary edema
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.159.1.9806024
– volume: 29
  start-page: 301
  year: 2001
  ident: ref_41
  article-title: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome
  publication-title: Nat. Genet.
  doi: 10.1038/ng756
– ident: ref_239
  doi: 10.1371/journal.pone.0108844
– volume: 23
  start-page: 692
  year: 2022
  ident: ref_75
  article-title: Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-022-01185-3
– volume: 78
  start-page: 482
  year: 1996
  ident: ref_11
  article-title: Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.78.3.482
– ident: ref_23
  doi: 10.3389/fphys.2015.00058
– volume: 527
  start-page: 389
  year: 2013
  ident: ref_73
  article-title: The HMGB1–TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis
  publication-title: Gene
  doi: 10.1016/j.gene.2013.05.041
– volume: 586
  start-page: 1022
  year: 2012
  ident: ref_54
  article-title: TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2012.02.045
– volume: 194
  start-page: 3937
  year: 2015
  ident: ref_70
  article-title: K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1402658
– volume: 26
  start-page: 48
  year: 2011
  ident: ref_5
  article-title: Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery
  publication-title: Perfusion
  doi: 10.1177/0267659111420607
– volume: 192
  start-page: 1015
  year: 2000
  ident: ref_127
  article-title: Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.192.7.1015
– volume: 106
  start-page: 237
  year: 2015
  ident: ref_24
  article-title: Distinct mPTP activation mechanisms in ischaemia–reperfusion: Contributions of Ca2+, ROS, pH, and inorganic polyphosphate
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvv097
– volume: 245
  start-page: 221
  year: 2020
  ident: ref_237
  article-title: Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats
  publication-title: Exp. Biol. Med.
  doi: 10.1177/1535370219899899
– volume: 39
  start-page: 787
  year: 2007
  ident: ref_19
  article-title: Mitochondrial permeability transition relevance for apoptotic triggering in the post-ischemic heart
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2007.01.013
– volume: 424
  start-page: 123
  year: 2017
  ident: ref_30
  article-title: Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-016-2849-0
– volume: 2016
  start-page: 5271251
  year: 2016
  ident: ref_97
  article-title: Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2016/5271251
– volume: 112
  start-page: 16
  year: 2017
  ident: ref_145
  article-title: Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s00395-017-0603-8
– volume: 1
  start-page: 201
  year: 1949
  ident: ref_100
  article-title: Endogenous formation of carbon monoxide in man under normal and pathological conditions
  publication-title: Scand. J. Clin. Investig.
  doi: 10.3109/00365514909069943
– volume: 110
  start-page: 291
  year: 2017
  ident: ref_236
  article-title: Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2017.06.016
– volume: 30
  start-page: 15811
  year: 2010
  ident: ref_81
  article-title: The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4088-10.2010
– volume: 19
  start-page: 785
  year: 1995
  ident: ref_163
  article-title: The role of the reactions of· NO with superoxide and oxygen in biological systems: A kinetic approach
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/0891-5849(95)00081-8
– volume: 24
  start-page: 873
  year: 1990
  ident: ref_14
  article-title: Intracellular pH and role of Na+/H+ exchange during ischaemia and reperfusion of normal and diabetic rat hearts
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/24.11.873
– volume: 2020
  start-page: 9219825
  year: 2020
  ident: ref_98
  article-title: Ticagrelor conditioning effects are not additive to cardioprotection induced by direct NLRP3 inflammasome inhibition: Role of RISK, NLRP3, and Redox Cascades
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2020/9219825
– volume: 49
  start-page: 892
  year: 1981
  ident: ref_10
  article-title: Total ischemia in dog hearts, in vitro. 1. Comparison of high energy phosphate production, utilization, and depletion, and of adenine nucleotide catabolism in total ischemia in vitro vs. severe ischemia in vivo
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.49.4.892
– volume: 377
  start-page: 239
  year: 1995
  ident: ref_149
  article-title: Hypertension in mice lacking the gene for endothelial nitric oxide synthase
  publication-title: Nature
  doi: 10.1038/377239a0
– volume: 101
  start-page: 53
  year: 2006
  ident: ref_206
  article-title: Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia–reperfusion injury
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s00395-005-0569-9
– volume: 16
  start-page: 157
  year: 2018
  ident: ref_28
  article-title: Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2018.02.019
– volume: 13
  start-page: 444
  year: 2021
  ident: ref_164
  article-title: Advanced nitric oxide donors: Chemical structure of NO drugs, NO nanomedicines and biomedical applications
  publication-title: Nanoscale
  doi: 10.1039/D0NR07484E
– volume: 33
  start-page: 216
  year: 2015
  ident: ref_201
  article-title: A novel hydrogen sulfide prodrug, SG 1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients
  publication-title: Cardiovasc. Ther.
  doi: 10.1111/1755-5922.12128
– volume: 90
  start-page: e17
  year: 2002
  ident: ref_112
  article-title: Carbon monoxide-releasing molecules: Characterization of biochemical and vascular activities
  publication-title: Circ. Res.
  doi: 10.1161/hh0202.104530
– volume: 278
  start-page: L312
  year: 2000
  ident: ref_129
  article-title: Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
  publication-title: Am. J. Physiol. Lung Cell Mol. Physiol.
  doi: 10.1152/ajplung.2000.278.2.L312
– volume: 224
  start-page: 591
  year: 1984
  ident: ref_197
  article-title: Interactions of sulphide and other ligands with cytochrome c oxidase. An electron-paramagnetic-resonance study
  publication-title: Biochem. J.
  doi: 10.1042/bj2240591
– volume: 73
  start-page: 964
  year: 2019
  ident: ref_1
  article-title: PCI and CABG for treating stable coronary artery disease: JACC review topic of the week
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2018.11.053
– volume: 526
  start-page: 660
  year: 2015
  ident: ref_83
  article-title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
  publication-title: Nature
  doi: 10.1038/nature15514
– volume: 60
  start-page: 185
  year: 1987
  ident: ref_15
  article-title: Relations among sodium pump inhibition, Na-Ca and Na-H exchange activities, and Ca-H interaction in cultured chick heart cells
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.60.2.185
– volume: 357
  start-page: 1121
  year: 2007
  ident: ref_67
  article-title: Myocardial reperfusion injury
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra071667
– volume: 9
  start-page: 365
  year: 2003
  ident: ref_31
  article-title: Systemic inflammatory response syndrome after cardiac surgery under cardiopulmonary bypass
  publication-title: Ann. Thorac. Cardiovasc. Surg.
– volume: 64
  start-page: 2836
  year: 2015
  ident: ref_178
  article-title: M2 macrophage polarization mediates anti-inflammatory effects of endothelial nitric oxide signaling
  publication-title: Diabetes
  doi: 10.2337/db14-1668
– volume: 105
  start-page: 365
  year: 2009
  ident: ref_226
  article-title: Hydrogen sulfide mediates cardioprotection through Nrf2 signaling
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.109.199919
– volume: 40
  start-page: 643
  year: 2019
  ident: ref_144
  article-title: Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2018.12.059
– volume: 13
  start-page: 76
  year: 1999
  ident: ref_228
  article-title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.1.76
– volume: 109
  start-page: 415
  year: 2014
  ident: ref_139
  article-title: TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s00395-014-0415-z
– volume: 37
  start-page: 101
  year: 2004
  ident: ref_22
  article-title: The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic–reperfused heart
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2004.04.009
– ident: ref_78
  doi: 10.3389/fcell.2020.00167
– ident: ref_242
  doi: 10.1242/bio.043653
– volume: 257
  start-page: 115542
  year: 2023
  ident: ref_95
  article-title: Discovery of a novel 1, 3, 4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2023.115542
– volume: 560
  start-page: 198
  year: 2018
  ident: ref_74
  article-title: New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
  publication-title: Nature
  doi: 10.1038/s41586-018-0372-z
– volume: 111
  start-page: 31
  year: 2012
  ident: ref_117
  article-title: Cell damage following carbon monoxide releasing molecule exposure: Implications for therapeutic applications
  publication-title: Basic Clin. Pharmacol. Toxicol.
  doi: 10.1111/j.1742-7843.2012.00856.x
– volume: 123
  start-page: 594
  year: 2011
  ident: ref_32
  article-title: Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.110.982777
– volume: 16
  start-page: 3247
  year: 2016
  ident: ref_59
  article-title: MLKL and FADD are critical for suppressing progressive lymphoproliferative disease and activating the NLRP3 inflammasome
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.06.103
– volume: 267
  start-page: H1353
  year: 1994
  ident: ref_9
  article-title: Ischemic preconditioning stimulates anaerobic glycolysis in the isolated rabbit heart
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.1994.267.4.H1353
– volume: 98
  start-page: 462
  year: 2013
  ident: ref_39
  article-title: The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β
  publication-title: Exp. Physiol.
  doi: 10.1113/expphysiol.2012.068338
– volume: 53
  start-page: 575
  year: 2014
  ident: ref_230
  article-title: Detection of protein S-sulfhydration by a tag-switch technique
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201305876
– volume: 269
  start-page: 27580
  year: 1994
  ident: ref_148
  article-title: Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)47024-X
– volume: 9
  start-page: 1037
  year: 2008
  ident: ref_55
  article-title: Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1638
– volume: 15
  start-page: 982
  year: 2014
  ident: ref_60
  article-title: Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201438463
– volume: 274
  start-page: 611
  year: 1991
  ident: ref_20
  article-title: Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin
  publication-title: Biochem. J.
  doi: 10.1042/bj2740611
– volume: 35
  start-page: 1766
  year: 2016
  ident: ref_85
  article-title: GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
  publication-title: EMBO J.
  doi: 10.15252/embj.201694696
– volume: 104
  start-page: 15478
  year: 2007
  ident: ref_179
  article-title: Nitric oxide induces CD4+ CD25+ Foxp3− regulatory T cells from CD4+ CD25− T cells via p53, IL-2, and OX40
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0703725104
– volume: 11
  start-page: 255
  year: 2014
  ident: ref_33
  article-title: The inflammatory response in myocardial injury, repair, and remodelling
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/nrcardio.2014.28
– volume: 19
  start-page: 284
  year: 2005
  ident: ref_113
  article-title: CORM-A1: A new pharmacologically active carbon monoxide-releasing molecule
  publication-title: FASEB J.
  doi: 10.1096/fj.04-2169fje
– volume: 174
  start-page: 342
  year: 1970
  ident: ref_110
  article-title: Physiological and biochemical effects on rats and mice exposed to small concentrations of carbon monoxide for long periods
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1970.tb49799.x
– volume: 15
  start-page: 774
  year: 1995
  ident: ref_158
  article-title: The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats
  publication-title: J. Cereb. Blood Flow. Metab.
  doi: 10.1038/jcbfm.1995.97
– volume: 90
  start-page: 135
  year: 2013
  ident: ref_217
  article-title: Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2013.09.002
– volume: 11
  start-page: 136
  year: 2010
  ident: ref_140
  article-title: Thioredoxin-interacting protein links oxidative stress to inflammasome activation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1831
– volume: 25
  start-page: 472
  year: 2020
  ident: ref_202
  article-title: Hydrogen sulfide therapy suppresses cofilin-2 and attenuates ischemic heart failure in a mouse model of myocardial infarction
  publication-title: J. Cardiovasc. Pharmacol. Ther.
  doi: 10.1177/1074248420923542
– ident: ref_4
  doi: 10.3389/fphys.2013.00228
– volume: 310
  start-page: H71
  year: 2016
  ident: ref_215
  article-title: MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00574.2014
– volume: 45
  start-page: 932
  year: 2013
  ident: ref_134
  article-title: ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2013.02.009
– volume: 36
  start-page: 651
  year: 1997
  ident: ref_175
  article-title: Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis
  publication-title: Br. J. Rheumatol.
  doi: 10.1093/rheumatology/36.6.651
– volume: 20
  start-page: 2118
  year: 2006
  ident: ref_199
  article-title: Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation
  publication-title: FASEB J.
  doi: 10.1096/fj.06-6270fje
– volume: 49
  start-page: 331
  year: 2013
  ident: ref_50
  article-title: Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.11.009
– volume: 287
  start-page: 2000
  year: 2020
  ident: ref_64
  article-title: Alterations in plasma membrane ion channel structures stimulate NLRP3 inflammasome activation in APOL1 risk milieu
  publication-title: FEBS J.
  doi: 10.1111/febs.15133
– volume: 327
  start-page: 524
  year: 1987
  ident: ref_146
  article-title: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
  publication-title: Nature
  doi: 10.1038/327524a0
– volume: 290
  start-page: H2024
  year: 2006
  ident: ref_26
  article-title: Reactive oxygen species, but not Ca2+ overloading, trigger pH-and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00683.2005
– volume: 110
  start-page: 96
  year: 2016
  ident: ref_189
  article-title: Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvw037
– volume: 308
  start-page: L1058
  year: 2015
  ident: ref_137
  article-title: Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages
  publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00400.2014
– volume: 109
  start-page: 524
  year: 1995
  ident: ref_171
  article-title: A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(95)90341-0
– volume: 3
  start-page: 193
  year: 2001
  ident: ref_183
  article-title: Protein S-nitrosylation: A physiological signal for neuronal nitric oxide
  publication-title: Nat. Cell Biol.
  doi: 10.1038/35055104
– volume: 55
  start-page: 1370
  year: 2022
  ident: ref_76
  article-title: Oxidized DNA fragments exit mitochondria via mPTP-and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.06.007
– volume: 11
  start-page: e202200350
  year: 2022
  ident: ref_121
  article-title: Mechanistic Studies of Carbon Monoxide Release from Norborn-2-en-7-one CORMs
  publication-title: Asian J. Org. Chem.
  doi: 10.1002/ajoc.202200350
– volume: 287
  start-page: 36617
  year: 2012
  ident: ref_48
  article-title: Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.407130
– volume: 14
  start-page: 812
  year: 2013
  ident: ref_234
  article-title: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2639
– volume: 20
  start-page: 6008
  year: 2001
  ident: ref_210
  article-title: The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
  publication-title: EMBO J.
  doi: 10.1093/emboj/20.21.6008
– volume: 108
  start-page: 19725
  year: 2011
  ident: ref_37
  article-title: The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1108586108
– volume: 40
  start-page: 1578
  year: 2016
  ident: ref_238
  article-title: Exogenous hydrogen sulfide attenuates high glucose-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation by suppressing TLR4/NF-κB pathway in H9c2 cells
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000453208
– ident: ref_77
  doi: 10.1038/s42003-023-04817-y
– ident: ref_246
  doi: 10.1371/journal.pone.0040643
– volume: 101
  start-page: 919
  year: 2007
  ident: ref_143
  article-title: Carbon Monoxide Induces Heme Oxygenase-1 via Activation of Protein Kinase R–Like Endoplasmic Reticulum Kinase and Inhibits Endothelial Cell Apoptosis Triggered by Endoplasmic Reticulum Stress
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.107.154781
– volume: 3
  start-page: 1329
  year: 2012
  ident: ref_71
  article-title: Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2339
– volume: 192
  start-page: 1835
  year: 2014
  ident: ref_58
  article-title: FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1302839
– volume: 15
  start-page: 556
  year: 2019
  ident: ref_89
  article-title: MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-019-0277-7
– volume: 350
  start-page: 9
  year: 1994
  ident: ref_169
  article-title: Evidence for nitric oxide-mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(94)00722-5
– ident: ref_205
  doi: 10.3390/ijms22115737
– volume: 115
  start-page: E1530
  year: 2018
  ident: ref_92
  article-title: OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1716095115
– volume: 24
  start-page: 329
  year: 2016
  ident: ref_209
  article-title: SIRT3 mediates the antioxidant effect of hydrogen sulfide in endothelial cells
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2015.6331
– ident: ref_120
  doi: 10.1016/j.bcp.2023.115642
– volume: 1864
  start-page: 1
  year: 2018
  ident: ref_233
  article-title: The SGK1 inhibitor EMD638683, prevents Angiotensin II–induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation
  publication-title: Biochim. Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2017.10.001
– volume: 206
  start-page: 267
  year: 1982
  ident: ref_193
  article-title: Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat
  publication-title: Biochem. J.
  doi: 10.1042/bj2060267
– volume: 17
  start-page: 250
  year: 2016
  ident: ref_44
  article-title: NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3333
– volume: 164
  start-page: 5120
  year: 2000
  ident: ref_69
  article-title: Potassium regulates IL-1β processing via calcium-independent phospholipase A2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.164.10.5120
– volume: 69
  start-page: 250
  year: 1984
  ident: ref_17
  article-title: The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction
  publication-title: Circulation
  doi: 10.1161/01.CIR.69.2.250
– volume: 7
  start-page: 10555
  year: 2016
  ident: ref_135
  article-title: Neutrophil P2X 7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms10555
– volume: 670
  start-page: 116
  year: 2019
  ident: ref_96
  article-title: Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/j.abb.2018.11.013
– volume: 15
  start-page: 560
  year: 2019
  ident: ref_90
  article-title: MCC950 closes the active conformation of NLRP3 to an inactive state
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-019-0278-6
– volume: 287
  start-page: 41732
  year: 2012
  ident: ref_42
  article-title: Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.381228
– volume: 469
  start-page: 221
  year: 2011
  ident: ref_52
  article-title: A role for mitochondria in NLRP3 inflammasome activation
  publication-title: Nature
  doi: 10.1038/nature09663
– volume: 535
  start-page: 111
  year: 2016
  ident: ref_84
  article-title: Pore-forming activity and structural autoinhibition of the gasdermin family
  publication-title: Nature
  doi: 10.1038/nature18590
– volume: 278
  start-page: 36993
  year: 2003
  ident: ref_130
  article-title: Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M302942200
– volume: 99
  start-page: 164
  year: 2013
  ident: ref_34
  article-title: The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvt091
– volume: 12
  start-page: e15974
  year: 2024
  ident: ref_122
  article-title: The carbon monoxide prodrug oCOm-21 increases Ca2+ sensitivity of the cardiac myofilament
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.15974
– volume: 42
  start-page: 404
  year: 2014
  ident: ref_165
  article-title: Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: Systematic review and meta-analysis
  publication-title: Crit. Care Med.
  doi: 10.1097/CCM.0b013e3182a27909
– volume: 6
  start-page: 372
  year: 1976
  ident: ref_109
  article-title: Mechanism of the toxic action of carbon monoxide
  publication-title: Ann. Clin. Lab. Sci.
– volume: 44
  start-page: 701
  year: 2008
  ident: ref_213
  article-title: Negative regulation of β-adrenergic function by hydrogen sulphide in the rat hearts
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2008.01.007
– volume: 6
  start-page: 422
  year: 2000
  ident: ref_124
  article-title: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
  publication-title: Nat. Med.
  doi: 10.1038/74680
– volume: 977
  start-page: 80
  year: 2003
  ident: ref_156
  article-title: Cardiovascular responses and neurotransmitter changes following blockade of nNOS within the ventrolateral medulla during static muscle contraction
  publication-title: Brain Res.
  doi: 10.1016/S0006-8993(03)02761-6
– volume: 36
  start-page: 774
  year: 2004
  ident: ref_162
  article-title: Resveratrol protects myocardial ischemia–reperfusion injury through both NO-dependent and NO-independent mechanisms
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2003.12.016
– volume: 183
  start-page: 792
  year: 2009
  ident: ref_53
  article-title: Cutting edge: TNF-α mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900173
– volume: 74
  start-page: 105575
  year: 2019
  ident: ref_91
  article-title: The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2019.04.022
– volume: 11
  start-page: 923
  year: 2006
  ident: ref_170
  article-title: Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion
  publication-title: Apoptosis
  doi: 10.1007/s10495-006-6305-6
– volume: 1491
  start-page: 188
  year: 2013
  ident: ref_218
  article-title: Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2012.10.046
– volume: 266
  start-page: 4244
  year: 1991
  ident: ref_167
  article-title: Peroxynitrite oxidation of sulfhydryls.: The cytotoxic potential of superoxide and nitric oxide
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(20)64313-7
– volume: 347
  start-page: 768
  year: 1990
  ident: ref_155
  article-title: Localization of nitric oxide synthase indicating a neural role for nitric oxide
  publication-title: Nature
  doi: 10.1038/347768a0
– volume: 613
  start-page: 595
  year: 2023
  ident: ref_45
  article-title: Cryo-EM structures of the active NLRP3 inflammasome disc
  publication-title: Nature
  doi: 10.1038/s41586-022-05570-8
– volume: 66
  start-page: 1561
  year: 1990
  ident: ref_151
  article-title: Control of coronary vascular tone by nitric oxide
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.66.6.1561
– volume: 291
  start-page: H1015
  year: 2006
  ident: ref_61
  article-title: Cardiac fibroblasts: Friend or foe?
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00023.2006
– volume: 271
  start-page: H876
  year: 1996
  ident: ref_18
  article-title: Effect of preconditioning on ryanodine-sensitive Ca2+ release from sarcoplasmic reticulum of rat heart
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.1996.271.3.H876
– volume: 862
  start-page: 172636
  year: 2019
  ident: ref_115
  article-title: The CO-releasing molecule CORM-3 protects adult cardiomyocytes against hypoxia-reoxygenation by modulating pH restoration
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2019.172636
– ident: ref_65
  doi: 10.1016/j.biopha.2020.110990
– volume: 24
  start-page: 317
  year: 2006
  ident: ref_46
  article-title: Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.02.004
– volume: 183
  start-page: 787
  year: 2009
  ident: ref_49
  article-title: Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901363
– volume: 125
  start-page: 1437
  year: 1998
  ident: ref_126
  article-title: Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1
  publication-title: Br. J. Pharmacol.
  doi: 10.1038/sj.bjp.0702212
– volume: 102
  start-page: 14515
  year: 2005
  ident: ref_161
  article-title: Imaging the nanomolar range of nitric oxide with an amplifier-coupled fluorescent indicator in living cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0505136102
– volume: 73
  start-page: 215
  year: 2019
  ident: ref_93
  article-title: The NLRP3 inflammasome inhibitor, OLT1177 (dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/FJC.0000000000000658
– volume: 606
  start-page: 205
  year: 2009
  ident: ref_194
  article-title: Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2009.01.041
– volume: 68
  start-page: 1250
  year: 1991
  ident: ref_16
  article-title: Amiloride delays the ischemia-induced rise in cytosolic free calcium
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.68.5.1250
– volume: 77
  start-page: 49
  year: 2021
  ident: ref_94
  article-title: Phase 1b, randomized, double-blinded, dose escalation, single-center, repeat dose safety and pharmacodynamics study of the oral nlrp3 inhibitor dapansutrile in subjects with nyha ii–iii systolic heart failure
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/FJC.0000000000000931
– volume: 65
  start-page: 3171
  year: 2016
  ident: ref_227
  article-title: Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation
  publication-title: Diabetes
  doi: 10.2337/db16-0020
– volume: 295
  start-page: C1261
  year: 2008
  ident: ref_212
  article-title: Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00195.2008
– volume: 1864
  start-page: 2890
  year: 2018
  ident: ref_231
  article-title: Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages
  publication-title: Biochim. Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2018.05.023
– volume: 281
  start-page: 1309
  year: 1998
  ident: ref_25
  article-title: Mitochondria and apoptosis
  publication-title: Science
  doi: 10.1126/science.281.5381.1309
– volume: 183
  start-page: 2008
  year: 2009
  ident: ref_40
  article-title: NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and-independent pathways
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900138
– volume: 96
  start-page: 657
  year: 1999
  ident: ref_150
  article-title: Nitric oxide synthase in cardiac sarcoplasmic reticulum
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.96.2.657
– volume: 127
  start-page: 44
  year: 2004
  ident: ref_190
  article-title: Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation
  publication-title: J. Thorac. Cardiovasc. Surg.
  doi: 10.1016/j.jtcvs.2002.08.001
– volume: 1853
  start-page: 396
  year: 2015
  ident: ref_66
  article-title: Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis
  publication-title: Biochim. Biophys. Acta Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2014.11.012
– volume: 36
  start-page: 718
  year: 1995
  ident: ref_177
  article-title: Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn’s disease
  publication-title: Gut
  doi: 10.1136/gut.36.5.718
– volume: 118
  start-page: 1253
  year: 2018
  ident: ref_195
  article-title: Chemical biology of H2S signaling through persulfidation
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.7b00205
– volume: 277
  start-page: 17950
  year: 2002
  ident: ref_128
  article-title: Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-κB to protect endothelial cells from tumor necrosis factor-α-mediated apoptosis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M108317200
– volume: 88
  start-page: 4651
  year: 1991
  ident: ref_152
  article-title: Nitric oxide: An endogenous modulator of leukocyte adhesion
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.88.11.4651
– volume: 166
  start-page: 3873
  year: 2001
  ident: ref_160
  article-title: Biphasic regulation of NF-κB activity underlies the pro-and anti-inflammatory actions of nitric oxide
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.166.6.3873
– volume: 72
  start-page: 15
  year: 2023
  ident: ref_241
  article-title: Hydrogen sulfide alleviates lipopolysaccharide-induced myocardial injury through TLR4-NLRP3 pathway
  publication-title: Physiol. Res.
  doi: 10.33549/physiolres.934928
– volume: 189
  start-page: 5113
  year: 2012
  ident: ref_181
  article-title: Cutting edge: Nitric oxide inhibits the NLRP3 inflammasome
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1202479
– volume: 51
  start-page: 1448
  year: 2018
  ident: ref_56
  article-title: Alpha-lipoic acid preconditioning and ischaemic postconditioning synergistically protect rats from cerebral injury induced by ischemia and reperfusion partly via inhibition TLR4/MyD88/NF-κB signaling pathway
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000495593
– volume: 26
  start-page: 154
  year: 2006
  ident: ref_219
  article-title: The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat
  publication-title: Shock
  doi: 10.1097/01.shk.0000225722.56681.64
– volume: 8
  start-page: 5454
  year: 2017
  ident: ref_111
  article-title: Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs
  publication-title: Chem. Sci.
  doi: 10.1039/C7SC01647F
– volume: 281
  start-page: 27836
  year: 2006
  ident: ref_173
  article-title: Ligand selectivity of soluble guanylyl cyclase: Effect of the hydrogen-bonding tyrosine in the distal heme pocket on binding of oxygen, nitric oxide, and carbon monoxide
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M601078200
– volume: 284
  start-page: 7853
  year: 2009
  ident: ref_72
  article-title: Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M808824200
– volume: 49
  start-page: 177
  year: 2020
  ident: ref_29
  article-title: Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy
  publication-title: J. Thromb. Thrombolysis
  doi: 10.1007/s11239-019-02026-1
– volume: 2017
  start-page: 9743280
  year: 2017
  ident: ref_240
  article-title: NLRP3 inflammasome activation-mediated pyroptosis aggravates myocardial ischemia/reperfusion injury in diabetic rats
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2017/9743280
– volume: 23
  start-page: 1023
  year: 2009
  ident: ref_118
  article-title: A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia
  publication-title: FASEB J.
  doi: 10.1096/fj.08-122804
– volume: 330
  start-page: 1057
  year: 1987
  ident: ref_153
  article-title: Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium
  publication-title: Lancet
  doi: 10.1016/S0140-6736(87)91481-4
– volume: 89
  start-page: 168
  year: 2001
  ident: ref_106
  article-title: Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
  publication-title: Circ. Res.
  doi: 10.1161/hh1401.093314
– volume: 358
  start-page: 1142
  year: 2007
  ident: ref_211
  article-title: Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2007.05.063
– volume: 79
  start-page: 632
  year: 2008
  ident: ref_214
  article-title: Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvn140
– volume: 113
  start-page: 6
  year: 2018
  ident: ref_204
  article-title: Pre-and postconditioning the heart with hydrogen sulfide (H2S) against ischemia/reperfusion injury in vivo: A systematic review and meta-analysis
  publication-title: Basic. Res. Cardiol.
  doi: 10.1007/s00395-017-0664-8
– volume: 93
  start-page: e2
  year: 2003
  ident: ref_114
  article-title: Cardioprotective actions by a water-soluble carbon monoxide–releasing molecule
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000084381.86567.08
– volume: 14
  start-page: 163
  year: 2017
  ident: ref_235
  article-title: Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-017-0940-4
– volume: 14
  start-page: 3215
  year: 2023
  ident: ref_119
  article-title: Reassessing CORM-A1: Redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor
  publication-title: Chem. Sci.
  doi: 10.1039/D3SC00411B
– volume: 112
  start-page: 187
  year: 2015
  ident: ref_223
  article-title: Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2015.03.009
– volume: 247
  start-page: 725
  year: 1997
  ident: ref_103
  article-title: Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1997.00725.x
– volume: 104
  start-page: 15560
  year: 2007
  ident: ref_220
  article-title: Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0705891104
– volume: 96
  start-page: 497
  year: 2001
  ident: ref_187
  article-title: Nifedipine limits infarct size via NO-dependent mechanisms in dogs
  publication-title: Basic Res. Cardiol.
  doi: 10.1007/s003950170032
– volume: 285
  start-page: 9792
  year: 2010
  ident: ref_184
  article-title: Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.082305
– volume: 209
  start-page: 215
  year: 2016
  ident: ref_38
  article-title: Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2016.02.043
– volume: 187
  start-page: 613
  year: 2011
  ident: ref_57
  article-title: Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1100613
– volume: 19
  start-page: 282
  year: 2010
  ident: ref_6
  article-title: Rheumatic heart disease in indigenous populations—New Zealand experience
  publication-title: Heart Lung Circ.
  doi: 10.1016/j.hlc.2010.02.021
– volume: 440
  start-page: 228
  year: 2006
  ident: ref_51
  article-title: Cryopyrin activates the inflammasome in response to toxins and ATP
  publication-title: Nature
  doi: 10.1038/nature04515
– volume: 48
  start-page: 1793
  year: 2011
  ident: ref_142
  article-title: Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2011.05.014
– volume: 1095
  start-page: 251
  year: 2007
  ident: ref_105
  article-title: Expression and Protective Role of Heme Oxygenase-1 in Delayed Myocardial Preconditioning
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1196/annals.1397.029
– volume: 92
  start-page: 2568
  year: 1995
  ident: ref_123
  article-title: Basis of guanylate cyclase activation by carbon monoxide
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.92.7.2568
– volume: 177
  start-page: 41
  year: 2014
  ident: ref_248
  article-title: Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression
  publication-title: Int. J. Cardiol.
  doi: 10.1016/j.ijcard.2014.09.148
– volume: 5
  start-page: 282
  year: 2005
  ident: ref_107
  article-title: Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both
  publication-title: Am. J. Transplant.
  doi: 10.1111/j.1600-6143.2004.00695.x
– volume: 65
  start-page: 1045
  year: 1989
  ident: ref_13
  article-title: Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.65.4.1045
– volume: 51
  start-page: 511
  year: 2019
  ident: ref_36
  article-title: Endoplasmic reticulum stress-induced NLRP1 inflammasome activation contributes to myocardial ischemia/reperfusion injury
  publication-title: Shock
  doi: 10.1097/SHK.0000000000001175
– volume: 4
  start-page: 44
  year: 2011
  ident: ref_35
  article-title: Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.109.931451
– volume: 449
  start-page: 613
  year: 2013
  ident: ref_43
  article-title: The CARD plays a critical role in ASC foci formation and inflammasome signalling
  publication-title: Biochem. J.
  doi: 10.1042/BJ20121198
– volume: 17
  start-page: 4196
  year: 2015
  ident: ref_198
  article-title: Diallyl trisulfide is a fast H2S donor, but diallyl disulfide is a slow one: The reaction pathways and intermediates of glutathione with polysulfides
  publication-title: Org. Lett.
  doi: 10.1021/acs.orglett.5b01962
– volume: 24
  start-page: 518
  year: 2021
  ident: ref_245
  article-title: Hydrogen sulfide attenuates renal I/R-induced activation of the inflammatory response and apoptosis via regulating Nrf2-mediated NLRP3 signaling pathway inhibition
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2021.12157
– volume: 26
  start-page: 578
  year: 2007
  ident: ref_172
  article-title: NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601521
– volume: 31
  start-page: 267
  year: 2009
  ident: ref_203
  article-title: Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R
  publication-title: Shock
  doi: 10.1097/SHK.0b013e318180ff89
– volume: 37
  start-page: 1633
  year: 2019
  ident: ref_244
  article-title: Hydrogen sulfide improves endothelial dysfunction by inhibiting the vicious cycle of NLRP3 inflammasome and oxidative stress in spontaneously hypertensive rats
  publication-title: J. Hypertens.
  doi: 10.1097/HJH.0000000000002101
– volume: 333
  start-page: 664
  year: 1988
  ident: ref_147
  article-title: Vascular endothelial cells synthesize nitric oxide from L-arginine
  publication-title: Nature
  doi: 10.1038/333664a0
– volume: 10
  start-page: 186
  year: 1957
  ident: ref_99
  article-title: Partition of carbon monoxide and oxygen between air and whole blood of rats, dogs and men as affected by plasma pH
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1957.10.2.186
– volume: 261
  start-page: 411
  year: 1986
  ident: ref_102
  article-title: Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)42488-4
– volume: 13
  start-page: 105
  year: 1989
  ident: ref_191
  article-title: Determination of sulfide in brain tissue by gas dialysis/ion chromatography: Postmortem studies and two case reports
  publication-title: J. Anal. Toxicol.
  doi: 10.1093/jat/13.2.105
– volume: 168
  start-page: 785
  year: 2013
  ident: ref_216
  article-title: Hydrogen sulphide–mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.2012.02187.x
– volume: 296
  start-page: H868
  year: 2009
  ident: ref_222
  article-title: Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO-and p38 MAPK-dependent mechanism
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.01111.2007
– volume: 280
  start-page: 8714
  year: 2005
  ident: ref_125
  article-title: Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M408092200
– volume: 93
  start-page: 3308
  year: 1996
  ident: ref_159
  article-title: Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.93.8.3308
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Snippet Myocardial ischaemia reperfusion injury (IRI) occurring from acute coronary artery disease or cardiac surgical interventions such as bypass surgery can result...
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SubjectTerms Adenosine triphosphate
Animals
Apoptosis
Carbon monoxide
Carbon Monoxide - metabolism
Cardiomyocytes
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Cell death
Cytokines
Gasotransmitters - metabolism
Heart
Humans
Hydrogen Sulfide - metabolism
Hydrogen Sulfide - pharmacology
Inflammasomes - metabolism
Ischemia
Kinases
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardial Reperfusion Injury - drug therapy
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - pathology
Myocardial Reperfusion Injury - prevention & control
Nitric oxide
Nitric Oxide - metabolism
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Proteins
Tumor necrosis factor-TNF
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Title Inhibitors of NLRP3 Inflammasome Formation: A Cardioprotective Role for the Gasotransmitters Carbon Monoxide, Nitric Oxide, and Hydrogen Sulphide in Acute Myocardial Infarction
URI https://www.ncbi.nlm.nih.gov/pubmed/39273196
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Volume 25
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