Neonatal 6-hydroxydopamine sympathectomy in normotensive and spontaneously hypertensive rat

• Published in: Pharmacology, biochemistry and behavior Vol. 2; no. 3; pp. 381 - 386
• Main Authors: Pappas, B.A., Peters, D.A.V., Saari, M., Sobrian, S.K., Minch, E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.1974
• Subjects: 6-OHDA; Activity; Adrenal Glands - enzymology; Analysis of Variance; Animals; Animals, Newborn; Behavior - drug effects; Behavior, Animal; Blood Pressure; Brain - metabolism; Brain Stem - metabolism; Carbon Radioisotopes; Chromatography, Ion Exchange; Dihydroxyphenylalanine - metabolism; Emotionality; Female; Ganglia, Autonomic - drug effects; Ganglia, Autonomic - physiology; Ganglia, Autonomic - physiopathology; Hydroxydopamines - pharmacology; Hypertension - physiopathology; Male; Norepinephrine - metabolism; Rats; Serotonin - biosynthesis; Spontaneous hypertension; Sympathectomy; Time Factors; Tyrosine 3-Monooxygenase - metabolism; Emotionality; 6-OHDA; Activity; Sympathectomy; Spontaneous hypertension

Neonatal sympathectomy was produced in rats from either a normotensive or spontaneously hypertensive (SHR) strain by repeated s.c. injections of hydroxydopamine (6-OHDA). The SHR rats were considerably more active than the normotensive rats in the open field and activity wheels. Emotionality, define...