Neonatal 6-hydroxydopamine sympathectomy in normotensive and spontaneously hypertensive rat
Neonatal sympathectomy was produced in rats from either a normotensive or spontaneously hypertensive (SHR) strain by repeated s.c. injections of hydroxydopamine (6-OHDA). The SHR rats were considerably more active than the normotensive rats in the open field and activity wheels. Emotionality, define...
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Published in | Pharmacology, biochemistry and behavior Vol. 2; no. 3; pp. 381 - 386 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.05.1974
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Abstract | Neonatal sympathectomy was produced in rats from either a normotensive or spontaneously hypertensive (SHR) strain by repeated s.c. injections of hydroxydopamine (6-OHDA). The SHR rats were considerably more active than the normotensive rats in the open field and activity wheels. Emotionality, defined by the profile of open field activity and defecation scores, was lower in the SHR. Neonatal 6-OHDA had no effect upon emotionality or running wheel activity. Adult endogenous brain norepinephrine was increased in brainstem and decreased in cortex of both strains by 6-OHDA. Tyrosine hydroxylase activity in the brains of normotensive, 6-OHDA injected rats varied directly with altered endogenous NE levels. Preliminary data also indicated increased serotonin synthesis in the brainstem of 6-OHDA injected rats. It was concluded that neonatal injections of 6-OHDA may cause selective degeneration of the descending and dorsal NE brain pathways, and that the behavioral effects of this treatment, while yet obscure, seem to resemble those produced by hippocampal lesions. |
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AbstractList | Neonatal sympathectomy was produced in rats from either a normotensive or spontaneously hypertensive (SHR) strain by repeated s.c. injections of hydroxydopamine (6-OHDA). The SHR rats were considerably more active than the normotensive rats in the open field and activity wheels. Emotionality, defined by the profile of open field activity and defecation scores, was lower in the SHR. Neonatal 6-OHDA had no effect upon emotionality or running wheel activity. Adult endogenous brain norepinephrine was increased in brainstem and decreased in cortex of both strains by 6-OHDA. Tyrosine hydroxylase activity in the brains of normotensive, 6-OHDA injected rats varied directly with altered endogenous NE levels. Preliminary data also indicated increased serotonin synthesis in the brainstem of 6-OHDA injected rats. It was concluded that neonatal injections of 6-OHDA may cause selective degeneration of the descending and dorsal NE brain pathways, and that the behavioral effects of this treatment, while yet obscure, seem to resemble those produced by hippocampal lesions. |
Author | Minch, E. Pappas, B.A. Saari, M. Peters, D.A.V. Sobrian, S.K. |
Author_xml | – sequence: 1 givenname: B.A. surname: Pappas fullname: Pappas, B.A. organization: Department of Psychology, Carleton University, Ottawa, Ontario, USA – sequence: 2 givenname: D.A.V. surname: Peters fullname: Peters, D.A.V. organization: Department of Psychology, Carleton University, Ottawa, Ontario, USA – sequence: 3 givenname: M. surname: Saari fullname: Saari, M. organization: Department of Psychology, Carleton University, Ottawa, Ontario, USA – sequence: 4 givenname: S.K. surname: Sobrian fullname: Sobrian, S.K. organization: Department of Psychology, Carleton University, Ottawa, Ontario, USA – sequence: 5 givenname: E. surname: Minch fullname: Minch, E. organization: Department of Psychology, Carleton University, Ottawa, Ontario, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4152115$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1111/j.1749-6632.1969.tb12983.x 10.1037/h0024599 10.1161/01.RES.15.2.161 10.1126/science.166.3910.1284 10.1016/0006-8993(73)90614-8 10.1111/j.1471-4159.1968.tb05924.x 10.1161/01.RES.28.3.330 10.1038/newbio244181a0 10.1038/newbio239247a0 10.1016/0024-3205(72)90035-5 10.1111/j.1476-5381.1972.tb07259.x 10.1016/0006-8993(72)90206-5 10.1016/0028-3908(71)90008-6 10.1139/o67-185 10.1016/0006-8993(73)90828-7 10.1037/h0033792 10.1111/j.1365-201X.1971.tb10998.x |
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Keywords | Emotionality 6-OHDA Activity Sympathectomy Spontaneous hypertension |
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References | Anton, Sayre (BIB2) 1962; 138 McGeer, Gibson, McGeer (BIB13) 1967; 45 Sachs, Jonsson (BIB18) 1972; 4 Saari, M. and B. A. Pappas. Neonatal 6-hydroxydopamine sympathectomy reduces foot shock-induced suppression in normotensive and hypertensive rats. Lew, Quay (BIB12) 1971; 2 Denenberg (BIB8) 1969; 159 Ungerstedt (BIB23) 1971; 367 Clark (BIB5) 1971; 28 in press. Douglas (BIB9) 1967; 67 Thierry, Sinus, Blanc, Glowinski (BIB21) 1973; 50 Bloom, Algeri, Gropetti, Revulta, Costa (BIB3) 1969; 166 Dahlstrom, Fuxe (BIB7) 1965; 64 Ungerstedt (BIB22) 1971 Clark, Laverty, Phelan (BIB6) 1972; 44 Pappas, Sobrian (BIB15) 1972; 11 Jarrard (BIB11) 1973; 79 Brody (BIB4) 1964; 15 Okamoto (BIB14) 1969; 7 Singh, De Champlain (BIB19) 1972; 48 Angeletti (BIB1) 1971; 10 Taylor, Clark, Laverty, Phelan (BIB20) 1972; 239 Peters, McGeer, McGeer (BIB16) 1968; 15 Hery, Rouer, Glowinski (BIB10) 1973; 58 Bloom (10.1016/0091-3057(74)90084-7_BIB3) 1969; 166 Pappas (10.1016/0091-3057(74)90084-7_BIB15) 1972; 11 Sachs (10.1016/0091-3057(74)90084-7_BIB18) 1972; 4 Okamoto (10.1016/0091-3057(74)90084-7_BIB14) 1969; 7 Taylor (10.1016/0091-3057(74)90084-7_BIB20) 1972; 239 Dahlstrom (10.1016/0091-3057(74)90084-7_BIB7) 1965; 64 Jarrard (10.1016/0091-3057(74)90084-7_BIB11) 1973; 79 Lew (10.1016/0091-3057(74)90084-7_BIB12) 1971; 2 McGeer (10.1016/0091-3057(74)90084-7_BIB13) 1967; 45 Peters (10.1016/0091-3057(74)90084-7_BIB16) 1968; 15 Hery (10.1016/0091-3057(74)90084-7_BIB10) 1973; 58 Angeletti (10.1016/0091-3057(74)90084-7_BIB1) 1971; 10 Clark (10.1016/0091-3057(74)90084-7_BIB5) 1971; 28 10.1016/0091-3057(74)90084-7_BIB17 Douglas (10.1016/0091-3057(74)90084-7_BIB9) 1967; 67 Singh (10.1016/0091-3057(74)90084-7_BIB19) 1972; 48 Thierry (10.1016/0091-3057(74)90084-7_BIB21) 1973; 50 Denenberg (10.1016/0091-3057(74)90084-7_BIB8) 1969; 159 Ungerstedt (10.1016/0091-3057(74)90084-7_BIB22) 1971 Brody (10.1016/0091-3057(74)90084-7_BIB4) 1964; 15 Anton (10.1016/0091-3057(74)90084-7_BIB2) 1962; 138 Clark (10.1016/0091-3057(74)90084-7_BIB6) 1972; 44 Ungerstedt (10.1016/0091-3057(74)90084-7_BIB23) 1971; 367 |
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Pharmac. contributor: fullname: Sachs – volume: 28 start-page: 330 year: 1971 ident: 10.1016/0091-3057(74)90084-7_BIB5 article-title: Effects of immunosympathectomy on development of high blood pressure in genetically hypertensive rats publication-title: Circulation Res. doi: 10.1161/01.RES.28.3.330 contributor: fullname: Clark – ident: 10.1016/0091-3057(74)90084-7_BIB17 doi: 10.1038/newbio244181a0 – volume: 239 start-page: 247 year: 1972 ident: 10.1016/0091-3057(74)90084-7_BIB20 article-title: Specific noradrenergic neurons destroyed by 6-hydroxydopamine injection into newborn rats publication-title: Nature New. Biol. doi: 10.1038/newbio239247a0 contributor: fullname: Taylor – volume: 11 start-page: 653 year: 1972 ident: 10.1016/0091-3057(74)90084-7_BIB15 article-title: Neonatal sympathectomy by 6-hydroxydopamine in the rat: no effects on behavior but changes in endogenous brain norepinephrine publication-title: Life Sci. doi: 10.1016/0024-3205(72)90035-5 contributor: fullname: Pappas – volume: 44 start-page: 233 year: 1972 ident: 10.1016/0091-3057(74)90084-7_BIB6 article-title: Long-lasting peripheral and central effects of 6-hydroxydopamine in rats publication-title: Br. J. Pharmac. doi: 10.1111/j.1476-5381.1972.tb07259.x contributor: fullname: Clark – volume: 48 start-page: 432 year: 1972 ident: 10.1016/0091-3057(74)90084-7_BIB19 article-title: Altered ontogenesis of central noradrenergic neurons following neonatal treatment with 6-hydroxydopamine publication-title: Brain Res. doi: 10.1016/0006-8993(72)90206-5 contributor: fullname: Singh – volume: 10 start-page: 55 year: 1971 ident: 10.1016/0091-3057(74)90084-7_BIB1 article-title: Chemical sympathectomy in new born animals publication-title: Neuropharmacology doi: 10.1016/0028-3908(71)90008-6 contributor: fullname: Angeletti – volume: 138 start-page: 370 year: 1962 ident: 10.1016/0091-3057(74)90084-7_BIB2 article-title: A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines publication-title: J. Pharmac. exp. Ther. contributor: fullname: Anton – volume: 64 start-page: 7 issue: suppl. 247 year: 1965 ident: 10.1016/0091-3057(74)90084-7_BIB7 article-title: Evidence for the existence of monoamine neurons in the central nervous system publication-title: Acta physiol. scand. contributor: fullname: Dahlstrom – volume: 45 start-page: 1557 year: 1967 ident: 10.1016/0091-3057(74)90084-7_BIB13 article-title: Some characteristics of brain tyrosine hydroxylase publication-title: Can. J. Biochem. doi: 10.1139/o67-185 contributor: fullname: McGeer – volume: 58 start-page: 135 year: 1973 ident: 10.1016/0091-3057(74)90084-7_BIB10 article-title: Effect of 6-hydroxydopamine on daily variations of 5-Ht synthesis in the hypothalamus of the rat publication-title: Brain Res. doi: 10.1016/0006-8993(73)90828-7 contributor: fullname: Hery – volume: 79 start-page: 1 year: 1973 ident: 10.1016/0091-3057(74)90084-7_BIB11 article-title: The hippocampus and motivation publication-title: Psychol. Bull. doi: 10.1037/h0033792 contributor: fullname: Jarrard – volume: 367 start-page: 1 year: 1971 ident: 10.1016/0091-3057(74)90084-7_BIB23 article-title: Stereotaxic mapping of the monoamine pathways in the rat brain publication-title: Acta physiol. scand. Suppl. doi: 10.1111/j.1365-201X.1971.tb10998.x contributor: fullname: Ungerstedt |
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SubjectTerms | 6-OHDA Activity Adrenal Glands - enzymology Analysis of Variance Animals Animals, Newborn Behavior - drug effects Behavior, Animal Blood Pressure Brain - metabolism Brain Stem - metabolism Carbon Radioisotopes Chromatography, Ion Exchange Dihydroxyphenylalanine - metabolism Emotionality Female Ganglia, Autonomic - drug effects Ganglia, Autonomic - physiology Ganglia, Autonomic - physiopathology Hydroxydopamines - pharmacology Hypertension - physiopathology Male Norepinephrine - metabolism Rats Serotonin - biosynthesis Spontaneous hypertension Sympathectomy Time Factors Tyrosine 3-Monooxygenase - metabolism |
Title | Neonatal 6-hydroxydopamine sympathectomy in normotensive and spontaneously hypertensive rat |
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