Chronic obstructive pulmonary disease as a cardiovascular risk factor. Results of a case-control study (CONSISTE study)
Chronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be related to a common pathogenic mechanism, but it could also be explained by the existence of common risk factors. The objective of this study was to determin...
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Published in | International journal of chronic obstructive pulmonary disease Vol. 7; pp. 679 - 686 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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New Zealand
Dove Medical Press Limited
01.01.2012
Dove Medical Press |
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Abstract | Chronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be related to a common pathogenic mechanism, but it could also be explained by the existence of common risk factors. The objective of this study was to determine whether COPD patients present greater cardiovascular comorbidity than control subjects and whether COPD can be considered a risk factor per se.
1200 COPD patients and 300 control subjects were recruited for this multicenter, cross-sectional, case-control study.
Compared with the control group, the COPD group showed a significantly higher prevalence of ischemic heart disease (12.5% versus 4.7%; P < 0.0001), cerebrovascular disease (10% versus 2%; P < 0.0001), and peripheral vascular disease (16.4% versus 4.1%; P < 0.001). In the univariate risk analysis, COPD, hypertension, diabetes, obesity, and dyslipidemia were risk factors for ischemic heart disease. In the multivariate analysis adjusted for the remaining factors, COPD was still an independent risk factor (odds ratio: 2.23; 95% confidence interval: 1.18-4.24; P = 0.014).
COPD patients show a high prevalence of cardiovascular disease, higher than expected given their age and the coexistence of classic cardiovascular risk factors. |
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AbstractList | Introduction: Chronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be related to a common pathogenic mechanism, but it could also be explained by the existence of common risk factors. The objective of this study was to determine whether COPD patients present greater cardiovascular comorbidity than control subjects and whether COPD can be considered a risk factor per se. Methods: 1200 COPD patients and 300 control subjects were recruited for this multicenter, cross-sectional, case-control study. Results: Compared with the control group, the COPD group showed a significantly higher prevalence of ischemic heart disease (12.5% versus 4.7%; P < 0.0001), cerebrovascular disease (10% versus 2%; P < 0.0001), and peripheral vascular disease (16.4% versus 4.1%; P < 0.001). In the univariate risk analysis, COPD, hypertension, diabetes, obesity, and dyslipidemia were risk factors for ischemic heart disease. In the multivariate analysis adjusted for the remaining factors, COPD was still an independent risk factor (odds ratio: 2.23; 95% confidence interval: 1.18-4.24; P = 0.014). Conclusion: COPD patients show a high prevalence of cardiovascular disease, higher than expected given their age and the coexistence of classic cardiovascular risk factors. Keywords: COPD, cardiovascular risk, ischemic heart disease INTRODUCTIONChronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be related to a common pathogenic mechanism, but it could also be explained by the existence of common risk factors. The objective of this study was to determine whether COPD patients present greater cardiovascular comorbidity than control subjects and whether COPD can be considered a risk factor per se. METHODS1200 COPD patients and 300 control subjects were recruited for this multicenter, cross-sectional, case-control study. RESULTSCompared with the control group, the COPD group showed a significantly higher prevalence of ischemic heart disease (12.5% versus 4.7%; P < 0.0001), cerebrovascular disease (10% versus 2%; P < 0.0001), and peripheral vascular disease (16.4% versus 4.1%; P < 0.001). In the univariate risk analysis, COPD, hypertension, diabetes, obesity, and dyslipidemia were risk factors for ischemic heart disease. In the multivariate analysis adjusted for the remaining factors, COPD was still an independent risk factor (odds ratio: 2.23; 95% confidence interval: 1.18-4.24; P = 0.014). CONCLUSIONCOPD patients show a high prevalence of cardiovascular disease, higher than expected given their age and the coexistence of classic cardiovascular risk factors. Chronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be related to a common pathogenic mechanism, but it could also be explained by the existence of common risk factors. The objective of this study was to determine whether COPD patients present greater cardiovascular comorbidity than control subjects and whether COPD can be considered a risk factor per se. 1200 COPD patients and 300 control subjects were recruited for this multicenter, cross-sectional, case-control study. Compared with the control group, the COPD group showed a significantly higher prevalence of ischemic heart disease (12.5% versus 4.7%; P < 0.0001), cerebrovascular disease (10% versus 2%; P < 0.0001), and peripheral vascular disease (16.4% versus 4.1%; P < 0.001). In the univariate risk analysis, COPD, hypertension, diabetes, obesity, and dyslipidemia were risk factors for ischemic heart disease. In the multivariate analysis adjusted for the remaining factors, COPD was still an independent risk factor (odds ratio: 2.23; 95% confidence interval: 1.18-4.24; P = 0.014). COPD patients show a high prevalence of cardiovascular disease, higher than expected given their age and the coexistence of classic cardiovascular risk factors. |
Audience | Academic |
Author | Rodriguez-Gonzalez Moro, Jose Miguel Lozano, Paz Vaquero Bellón-Cano, Jose M de Lucas-Ramos, Pilar Izquierdo-Alonso, Jose Luis Frances, Jesus Fernandez |
AuthorAffiliation | 2 Servicio de Neumologia, Hospital Universitario de Guadalajara, Guadalajara 1 Servicio de Neumologia, Hospital General Universitario Gregorio Maranon, Madrid 3 Unidad de Investigacion, Hospital General Universitario Gregorio Maranon, Madrid, Spain |
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Author_xml | – sequence: 1 givenname: Pilar surname: de Lucas-Ramos fullname: de Lucas-Ramos, Pilar email: pilar.delucas@gmail.com organization: Servicio de Neumologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain. pilar.delucas@gmail.com – sequence: 2 givenname: Jose Luis surname: Izquierdo-Alonso fullname: Izquierdo-Alonso, Jose Luis – sequence: 3 givenname: Jose Miguel surname: Rodriguez-Gonzalez Moro fullname: Rodriguez-Gonzalez Moro, Jose Miguel – sequence: 4 givenname: Jesus Fernandez surname: Frances fullname: Frances, Jesus Fernandez – sequence: 5 givenname: Paz Vaquero surname: Lozano fullname: Lozano, Paz Vaquero – sequence: 6 givenname: Jose M surname: Bellón-Cano fullname: Bellón-Cano, Jose M |
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CitedBy_id | crossref_primary_10_36660_abc_20190623 crossref_primary_10_1016_j_arbr_2018_09_006 crossref_primary_10_1159_000492594 crossref_primary_10_1038_s41598_017_11189_x crossref_primary_10_2147_COPD_S410416 crossref_primary_10_1186_s12890_018_0694_5 crossref_primary_10_2147_COPD_S242009 crossref_primary_10_26442_00403660_2019_03_000110 crossref_primary_10_1016_j_arbres_2018_03_021 crossref_primary_10_1186_s13104_022_05930_7 crossref_primary_10_1159_000439229 crossref_primary_10_1007_s13760_019_01170_y crossref_primary_10_1155_2013_521087 crossref_primary_10_32902_2663_0338_2019_3_5_15 crossref_primary_10_3389_fmed_2017_00246 |
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Snippet | Chronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be related to a... Introduction: Chronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be... INTRODUCTIONChronic obstructive pulmonary disease (COPD) patients present a high prevalence of cardiovascular disease. This excess of comorbidity could be... |
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SubjectTerms | Age Factors Aged Cardiovascular diseases Cardiovascular Diseases - epidemiology Case-Control Studies Chi-Square Distribution Comorbidity Complications and side effects Cross-Sectional Studies Female Humans Logistic Models Lung diseases, Obstructive Male Middle Aged Multivariate Analysis Odds Ratio Original Research Prevalence Pulmonary Disease, Chronic Obstructive - epidemiology Risk Assessment Risk Factors Spain - epidemiology |
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Title | Chronic obstructive pulmonary disease as a cardiovascular risk factor. Results of a case-control study (CONSISTE study) |
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