Structural based insights into the role of troponin in cardiac muscle pathophysiology

• Published in: Journal of muscle research and cell motility Vol. 25; no. 7; pp. 559 - 579
• Main Authors: Li, Monica X., Wang, Xu, Sykes, Brian D.
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.01.2004
• Subjects: Animals; Calcium - metabolism; Cardiology; Cardiomyopathies - genetics; Cardiomyopathies - physiopathology; Heart attacks; Humans; Myocardial Contraction - drug effects; Myocardial Contraction - genetics; Myocardial Contraction - physiology; Myocardial Infarction - physiopathology; Myocytes, Cardiac - chemistry; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - physiology; Phosphorylation; Protein Binding - drug effects; Protein Binding - physiology; Protein Structure, Tertiary; Proteins; Troponin - chemistry; Troponin - genetics; Troponin - physiology

Troponin is a molecular switch, directly regulating the Ca2+-dependent activation of myofilament in striated muscle contraction. Cardiac troponin is subject to covalent and noncovalent modifications; phosphorylation modulates myofilament physiology, mutations are linked to familial hypertrophic card...