Modelling antibiotic- and anti-quorum sensing treatment of a spatially-structured Pseudomonas aeruginosa population

• Published in: Journal of mathematical biology Vol. 51; no. 5; pp. 557 - 594
• Main Authors: Anguige, K., King, J.R., Ward, J.P.
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.11.2005
• Subjects: 4-Butyrolactone - analogs & derivatives; 4-Butyrolactone - metabolism; Anti-Bacterial Agents - pharmacology; Bacteria; Bacteriology; Biofilms - drug effects; Biofilms - growth & development; Homoserine - analogs & derivatives; Homoserine - metabolism; Humans; Mathematics; Models, Biological; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - pathogenicity; Pseudomonas aeruginosa - physiology; Signal Transduction - drug effects; Virulence - drug effects; Virulence - physiology

The bacterial cell to cell signalling system known as quorum sensing (QS) is essential for the regulation of virulence in many pathogens and offers a specific biochemical target for novel antibacterial therapies. Expanding on earlier work, in which consideration was given to the primary QS system (l...