Evaluating lactate metabolism for prognostic assessment and therapy response prediction in gastric cancer with emphasis on the oncogenic role of SLC5A12

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 2; p. 130739
• Main Authors: Lin, Chenyi, Ye, Jianjian, Xu, Chao, Zheng, Ying, Xu, Yining, Chen, Yuluo, Chi, Liangjie, Lin, Jia, Li, Feng, Lin, Yao, Wang, Qingshui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2025
• Subjects: Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell Line, Tumor; Cell Proliferation; Chemotherapy; Female; Gastric cancer; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Lactate; Lactic Acid - metabolism; Male; Prognosis; SLC5A12; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach Neoplasms - therapy; Zebrafish; SLC5A12; Chemotherapy; Lactate; Gastric cancer; Immunotherapy

Gastric cancer remains a common malignancy with poor prognosis. While lactate metabolism is recognized as a significant factor in tumor progression, its potential as a predictive tool for treatment response remains unexplored. This study introduces a novel Lactate-Related Gene Signature (LRGS) desig...