Mixture cure model with an application to interval mapping of quantitative trait loci

• Published in: Lifetime data analysis Vol. 12; no. 4; pp. 421 - 440
• Main Authors: Liu, Mengling, Lu, Wenbin, Shao, Yongzhao
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.12.2006
• Subjects: Algorithms; Animals; Biometry; Genomes; Interval arithmetic; Listeria; Listeria monocytogenes; Listeriosis - genetics; Mice; Models, Genetic; Models, Statistical; Proportional Hazards Models; Quantitative Trait Loci; Statistical methods; Studies; Survival analysis; Time Factors

When censored time-to-event data are used to map quantitative trait loci (QTL), the existence of nonsusceptible subjects entails extra challenges. If the heterogeneous susceptibility is ignored or inappropriately handled, we may either fail to detect the responsible genetic factors or find spuriousl...