Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review
This narrative review explores the pathophysiology of obesity, cellular senescence, and exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial dysfunction and generate reactive oxygen species with DNA damage. This triggers adipocyte hypertrophy and hypoxia, inhibition...
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| Published in | International journal of molecular sciences Vol. 25; no. 14; p. 7943 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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20.07.2024
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| Abstract | This narrative review explores the pathophysiology of obesity, cellular senescence, and exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial dysfunction and generate reactive oxygen species with DNA damage. This triggers adipocyte hypertrophy and hypoxia, inhibition of adiponectin secretion and adipogenesis, increased endoplasmic reticulum stress and maladaptive unfolded protein response, metaflammation, and polarization of macrophages. Such feed-forward cycles are not resolved by antioxidant systems, heat shock response pathways, or DNA repair mechanisms, resulting in transmissible cellular senescence via autocrine, paracrine, and endocrine signaling. Senescence can thus affect preadipocytes, mature adipocytes, tissue macrophages and lymphocytes, hepatocytes, vascular endothelium, pancreatic β cells, myocytes, hypothalamic nuclei, and renal podocytes. The senescence-associated secretory phenotype is closely related to visceral adipose tissue expansion and metaflammation; inhibition of SIRT-1, adiponectin, and autophagy; and increased release of exosomes, exosomal micro-RNAs, pro-inflammatory adipokines, and saturated free fatty acids. The resulting hypernefemia, insulin resistance, and diminished fatty acid β-oxidation lead to lipotoxicity and progressive obesity, metabolic syndrome, and physical and cognitive functional decline. Weight cycling is related to continuing immunosenescence and exposure to palmitate. Cellular senescence, exosome release, and the transmissible senescence-associated secretory phenotype contribute to obesity and metabolic syndrome. Targeted therapies have interrelated and synergistic effects on cellular senescence, obesity, and premature aging. |
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| AbstractList | This narrative review explores the pathophysiology of obesity, cellular senescence, and exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial dysfunction and generate reactive oxygen species with DNA damage. This triggers adipocyte hypertrophy and hypoxia, inhibition of adiponectin secretion and adipogenesis, increased endoplasmic reticulum stress and maladaptive unfolded protein response, metaflammation, and polarization of macrophages. Such feed-forward cycles are not resolved by antioxidant systems, heat shock response pathways, or DNA repair mechanisms, resulting in transmissible cellular senescence via autocrine, paracrine, and endocrine signaling. Senescence can thus affect preadipocytes, mature adipocytes, tissue macrophages and lymphocytes, hepatocytes, vascular endothelium, pancreatic β cells, myocytes, hypothalamic nuclei, and renal podocytes. The senescence-associated secretory phenotype is closely related to visceral adipose tissue expansion and metaflammation; inhibition of SIRT-1, adiponectin, and autophagy; and increased release of exosomes, exosomal micro-RNAs, pro-inflammatory adipokines, and saturated free fatty acids. The resulting hypernefemia, insulin resistance, and diminished fatty acid β-oxidation lead to lipotoxicity and progressive obesity, metabolic syndrome, and physical and cognitive functional decline. Weight cycling is related to continuing immunosenescence and exposure to palmitate. Cellular senescence, exosome release, and the transmissible senescence-associated secretory phenotype contribute to obesity and metabolic syndrome. Targeted therapies have interrelated and synergistic effects on cellular senescence, obesity, and premature aging. This narrative review explores the pathophysiology of obesity, cellular senescence, and exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial dysfunction and generate reactive oxygen species with DNA damage. This triggers adipocyte hypertrophy and hypoxia, inhibition of adiponectin secretion and adipogenesis, increased endoplasmic reticulum stress and maladaptive unfolded protein response, metaflammation, and polarization of macrophages. Such feed-forward cycles are not resolved by antioxidant systems, heat shock response pathways, or DNA repair mechanisms, resulting in transmissible cellular senescence via autocrine, paracrine, and endocrine signaling. Senescence can thus affect preadipocytes, mature adipocytes, tissue macrophages and lymphocytes, hepatocytes, vascular endothelium, pancreatic β cells, myocytes, hypothalamic nuclei, and renal podocytes. The senescence-associated secretory phenotype is closely related to visceral adipose tissue expansion and metaflammation; inhibition of SIRT-1, adiponectin, and autophagy; and increased release of exosomes, exosomal micro-RNAs, pro-inflammatory adipokines, and saturated free fatty acids. The resulting hypernefemia, insulin resistance, and diminished fatty acid β-oxidation lead to lipotoxicity and progressive obesity, metabolic syndrome, and physical and cognitive functional decline. Weight cycling is related to continuing immunosenescence and exposure to palmitate. Cellular senescence, exosome release, and the transmissible senescence-associated secretory phenotype contribute to obesity and metabolic syndrome. Targeted therapies have interrelated and synergistic effects on cellular senescence, obesity, and premature aging.This narrative review explores the pathophysiology of obesity, cellular senescence, and exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial dysfunction and generate reactive oxygen species with DNA damage. This triggers adipocyte hypertrophy and hypoxia, inhibition of adiponectin secretion and adipogenesis, increased endoplasmic reticulum stress and maladaptive unfolded protein response, metaflammation, and polarization of macrophages. Such feed-forward cycles are not resolved by antioxidant systems, heat shock response pathways, or DNA repair mechanisms, resulting in transmissible cellular senescence via autocrine, paracrine, and endocrine signaling. Senescence can thus affect preadipocytes, mature adipocytes, tissue macrophages and lymphocytes, hepatocytes, vascular endothelium, pancreatic β cells, myocytes, hypothalamic nuclei, and renal podocytes. The senescence-associated secretory phenotype is closely related to visceral adipose tissue expansion and metaflammation; inhibition of SIRT-1, adiponectin, and autophagy; and increased release of exosomes, exosomal micro-RNAs, pro-inflammatory adipokines, and saturated free fatty acids. The resulting hypernefemia, insulin resistance, and diminished fatty acid β-oxidation lead to lipotoxicity and progressive obesity, metabolic syndrome, and physical and cognitive functional decline. Weight cycling is related to continuing immunosenescence and exposure to palmitate. Cellular senescence, exosome release, and the transmissible senescence-associated secretory phenotype contribute to obesity and metabolic syndrome. Targeted therapies have interrelated and synergistic effects on cellular senescence, obesity, and premature aging. |
| Author | Liang, Yicong Wilson, Robert Beaumont Kaushal, Devesh |
| Author_xml | – sequence: 1 givenname: Yicong surname: Liang fullname: Liang, Yicong – sequence: 2 givenname: Devesh surname: Kaushal fullname: Kaushal, Devesh – sequence: 3 givenname: Robert Beaumont orcidid: 0000-0002-7408-4695 surname: Wilson fullname: Wilson, Robert Beaumont |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39063184$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_oby_24239 crossref_primary_10_3390_antiox14010099 |
| Cites_doi | 10.1016/j.bbadis.2024.167095 10.3389/fcell.2021.674103 10.1074/jbc.M313478200 10.3390/ijms20092358 10.3390/ncrna9050053 10.1016/j.celrep.2023.112866 10.1038/s41580-020-0251-y 10.1038/s41598-019-44834-8 10.1038/s41574-023-00943-z 10.1111/acel.13767 10.3390/ijms24010629 10.1038/nrm3823 10.1002/oby.20847 10.1007/s12079-014-0251-9 10.1083/jcb.201904113 10.3390/ijms21155505 10.1038/s41423-021-00791-9 10.3390/metabo13050675 10.1016/S2213-8587(23)00235-8 10.1146/annurev-pathol-012615-044359 10.1194/jlr.R083915 10.3389/fendo.2022.739882 10.1194/jlr.M800019-JLR200 10.7150/thno.42167 10.1073/pnas.2205626119 10.1016/j.cmet.2021.09.001 10.1097/j.pbj.0000000000000120 10.7554/eLife.65108 10.1016/j.jare.2024.01.027 10.1038/s41598-022-15331-2 10.1186/s12944-020-01342-3 10.7150/ijbs.27173 10.1038/s41467-019-10348-0 10.1016/j.molmet.2024.101880 10.3389/fcell.2020.599048 10.1016/j.atherosclerosis.2019.01.013 10.1016/j.diabet.2019.02.006 10.1007/s00109-016-1446-8 10.3390/membranes12111083 10.3390/ijms24097898 10.1038/srep22862 10.3390/biom10121699 10.3390/antiox12030760 10.3390/nu10040432 10.1038/s41422-020-00409-1 10.3390/nu14061137 10.20944/preprints202401.0975.v1 10.1194/jlr.R067520 10.3390/nu5062019 10.3389/fphar.2021.614068 10.1172/JCI83885 10.1007/978-3-030-12734-3_6 10.1002/oby.22493 10.1002/oby.22626 10.1371/journal.pone.0105262 10.1371/journal.pone.0123110 10.1002/hep.23280 10.1002/oby.23559 10.1007/s11357-022-00536-0 10.1016/j.jbc.2022.102716 10.1038/ng.3620 10.1016/j.cell.2020.07.021 10.15252/embr.201643184 10.1080/15384101.2019.1638694 10.1016/j.bbrc.2010.07.008 10.1161/01.ATV.10.4.493 10.1016/j.ebiom.2018.09.015 10.3389/fcell.2022.822816 10.3389/fcell.2022.817877 10.1126/scisignal.2004512 10.1038/s41423-021-00804-7 10.3389/fphys.2021.801340 10.1093/jmcb/mjw040 10.1038/s41401-021-00819-w 10.1017/S095442241400002X 10.1038/s41467-022-29822-3 10.1172/JCI200319246 10.3389/fendo.2021.650158 10.1172/JCI123069 10.1159/000492851 10.1074/jbc.M607215200 10.1016/j.bbadis.2013.05.029 10.3390/cells11213443 10.1136/bjsports-2022-106304 10.1002/mnfr.201700917 10.1038/s41366-021-00757-x 10.1186/1743-7075-3-35 10.1016/j.exger.2022.111896 10.1016/j.redox.2022.102410 10.1113/JP276957 10.1016/j.bbalip.2015.04.005 10.1111/acel.12950 10.3389/fimmu.2022.977485 10.3389/fendo.2019.00038 10.14336/AD.2021.0928 10.1038/s41586-021-04234-3 10.3389/fimmu.2022.1019313 10.1016/j.mam.2015.01.001 10.1016/j.ymben.2023.04.010 10.3892/mmr.2014.2532 10.3390/cells8091071 10.1177/1535370217708978 10.1152/ajpcell.00265.2014 10.1007/s12603-017-0968-2 10.1038/s41574-020-0335-y 10.1128/MCB.00508-18 10.1074/jbc.M200958200 10.3390/vaccines11020261 10.1083/jcb.201409063 10.1136/gutjnl-2016-313155 10.1038/nchembio.2342 10.1515/hmbci-2014-0023 10.1101/gad.180406.111 10.1210/en.2015-1803 10.1371/journal.pone.0198889 10.2337/db06-S002 10.1371/journal.pone.0252547 10.1038/414799a 10.1080/21623945.2023.2194034 10.1038/cddis.2017.76 10.1161/01.ATV.0000164313.17167.df 10.3390/biom10040534 10.3390/ijms232012185 10.1210/jc.2004-0535 10.1111/febs.16361 10.3389/fphys.2021.627837 10.3390/cells11040746 10.1016/S2666-7568(21)00300-7 10.3389/fendo.2022.957616 10.1038/s41556-022-00842-x 10.3389/fphys.2020.00091 10.3389/fnut.2021.625331 10.3390/cells11081336 10.1186/s12915-021-01181-3 10.20945/2359-3997000000631 10.1152/ajpregu.00238.2021 10.1038/s41574-024-01008-5 10.1016/j.biochi.2018.09.011 10.1096/fj.202101988R 10.1038/s42255-022-00687-6 10.1083/jcb.201201077 10.1007/s00223-023-01138-4 10.1007/s11357-023-00830-5 10.3389/fimmu.2022.824188 10.1038/ejcn.2017.155 10.3389/fphys.2022.826314 10.1038/s12276-023-00965-7 10.7150/ijbs.84890 10.1096/fj.202201117 10.1038/ncomms3712 10.3389/fimmu.2019.01462 10.1038/nrgastro.2013.149 10.3892/etm.2020.9410 10.1038/cddis.2013.134 10.1152/ajpregu.00114.2016 10.3390/antiox11071336 10.1016/j.semcdb.2017.08.022 10.12659/MSM.919721 10.1007/s10059-013-0297-1 10.1002/oby.22932 10.3389/fphar.2022.838277 10.1016/j.mad.2020.111229 10.1152/ajpendo.00093.2009 10.3390/ijms23116048 10.1155/2012/983814 10.1111/bjd.17984 10.1007/s00018-021-03973-w 10.1038/s41467-022-32515-6 10.1242/jcs.170373 10.1038/s41591-023-02614-y 10.1136/jitc-2020-001372 10.3390/cells11030497 10.1016/j.cell.2017.08.035 10.1172/JCI81993 10.1038/s41590-021-00880-x 10.1186/s12979-023-00378-0 10.1172/jci.insight.89908 10.3390/ijms24076192 10.1210/clinem/dgad152 10.1016/j.jcmgh.2015.07.007 10.1007/s11357-023-00843-0 10.1242/jcs.037200 10.1038/s41576-021-00414-z 10.1038/s43587-024-00642-y 10.3390/ijms222413384 10.1155/2021/6634536 10.1210/clinem/dgad550 10.3892/ijmm.2021.5065 10.3390/ijms24021337 10.1111/dom.12154 10.3390/ijms18061321 10.1210/jc.2018-01833 10.1159/000492252 10.3390/cells9122598 10.1007/s00109-024-02444-6 10.34067/KID.0000000000000284 10.1038/s41586-023-06621-4 10.1172/JCI153357 10.1007/s13679-023-00526-z 10.1038/nrd.2016.75 10.1016/j.tibs.2020.02.005 10.3389/fimmu.2018.00738 10.1186/s12964-020-00546-5 10.1038/s41591-021-01501-8 10.1016/j.cmet.2013.11.001 10.3389/fcvm.2023.1046495 10.1002/hep.28814 10.1155/2022/7175027 10.1038/s41467-021-22103-5 10.1038/s41467-021-22106-2 10.1002/jex2.96 10.7150/thno.22565 10.3390/cells10020233 10.1016/j.molmet.2022.101464 10.3390/nu11122923 10.1038/srep27486 10.1111/dom.14725 10.1038/s41467-021-22272-3 10.1152/ajpcell.00151.2014 10.1080/21623945.2021.1983242 10.1016/bs.acr.2018.05.004 10.1038/s41467-024-47359-5 10.1007/s11695-019-04295-4 10.1186/s12929-023-00964-w 10.3389/fimmu.2022.984859 10.1016/j.cell.2013.06.009 10.1172/JCI23621 10.3389/fimmu.2022.1044737 10.1136/bmj.p1400 10.1016/j.cmet.2021.03.019 10.1038/nature21365 10.1073/pnas.1808855115 10.1080/10408398.2022.2138257 10.3389/fragi.2021.790702 10.1186/s12964-021-00730-1 10.3233/NHA-1614 10.1038/s41598-021-02544-0 10.1126/science.aaw2586 10.1101/cshperspect.a041247 10.1007/s11892-022-01493-w 10.1016/0014-4827(65)90211-9 10.3390/ijms232314920 10.1038/s41467-020-16347-w 10.1002/oby.20919 10.1038/s41598-019-39882-z 10.1371/journal.pone.0165962 10.1096/fj.202100385R 10.1016/j.mce.2022.111619 10.1002/hep.28252 10.1007/s11154-020-09625-x 10.3389/fendo.2022.873865 10.1002/bies.201600235 10.1016/j.jnutbio.2013.02.012 10.3390/ijms22084039 10.1038/srep15971 10.3390/ijms222413529 10.1126/science.aau6977 10.3389/fendo.2019.00577 10.1111/j.1742-7843.2009.00420.x 10.3389/fcell.2020.616161 10.1038/s41580-018-0044-8 10.2147/DMSO.S186565 10.1016/j.jff.2021.104901 10.1038/s41594-022-00790-y 10.1016/j.mce.2022.111740 10.3390/cells8030214 10.1186/s12916-022-02672-y 10.1016/j.mam.2017.11.010 10.1371/journal.pone.0180614 10.1186/s13098-021-00623-w 10.1016/j.cmet.2021.08.006 10.1194/jlr.M500294-JLR200 10.1002/oby.21709 10.1016/j.ymthe.2022.03.008 10.1172/JCI26498 10.1111/apha.13339 10.3389/fbioe.2022.948959 10.1053/j.gastro.2017.01.052 10.1016/j.bj.2017.06.007 10.1159/000521241 10.3390/ijms23169252 10.1038/s41366-023-01406-1 10.1038/s41467-024-45125-1 10.3390/cancers13051157 10.1194/jlr.M072454 10.1002/oby.23745 10.1016/j.bbapap.2018.11.009 10.3390/cells11091424 10.3389/fphys.2021.733453 10.1038/s12276-024-01209-y 10.1091/mbc.e12-03-0251 10.3389/fphar.2023.1188829 10.3390/nu15030703 10.3390/ijms19051327 10.1210/endocr/bqab058 10.1172/JCI45887 10.1002/oby.20365 10.1016/j.coi.2019.08.002 10.1016/j.clnu.2020.11.030 10.1186/s12935-024-03296-3 10.18632/aging.103607 10.15252/embr.202357265 10.1002/agm2.12106 10.3390/nu12082348 10.1038/s42255-021-00467-8 10.1007/s11095-020-02941-6 10.1053/j.gastro.2015.12.037 10.1007/s40618-020-01453-9 10.1016/j.livres.2018.09.003 10.2337/db20-0293 10.1002/oby.20961 10.3390/biom10050761 10.1371/journal.pone.0019139 10.1016/j.mad.2018.10.005 10.26508/lsa.202101286 10.3390/nu15122749 10.3390/ijms24021703 10.1093/nar/gky223 10.2337/db09-0216 10.3390/metabo13121190 10.3390/ijms22041788 10.2147/IJGM.S428482 10.1038/s41598-018-22962-x 10.1097/MCO.0000000000000077 10.1096/fj.201900600RR 10.1111/bph.13792 10.1002/oby.22379 10.1161/JAHA.117.007442 10.1038/s41392-022-01178-6 10.3389/fphar.2019.00977 10.3389/fimmu.2022.831168 10.3389/fcell.2022.985274 10.1038/s41467-024-45724-y 10.3389/fimmu.2022.1068986 10.1186/s13287-019-1177-1 10.1038/s43587-024-00663-7 10.1016/j.brainres.2023.148367 10.1016/j.cmet.2024.03.008 10.1038/s41366-018-0212-0 10.1038/nsmb.2296 |
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| Publisher_xml | – name: MDPI AG |
| References | ref_136 ref_257 ref_138 Kanda (ref_221) 2006; 116 Breyne (ref_155) 2020; 21 Ibrahim (ref_275) 2016; 63 Blandin (ref_83) 2023; 42 Camargo (ref_44) 2013; 24 Rabhi (ref_237) 2022; 5 Plaza (ref_337) 2020; 12 Kalko (ref_160) 2018; 115 ref_133 Kalluri (ref_135) 2020; 367 Povero (ref_173) 2013; 6 ref_253 ref_256 Murphy (ref_304) 2023; 31 ref_95 Raffaele (ref_330) 2022; 3 Cinti (ref_231) 2005; 46 Guo (ref_62) 2019; 25 Zhu (ref_51) 2020; 187 Wilcox (ref_269) 2005; 26 Zoico (ref_333) 2021; 11 Povero (ref_172) 2015; 1 ref_246 ref_249 Recchia (ref_326) 2023; 57 Makarenkov (ref_258) 2024; 109 Xu (ref_229) 2013; 18 ref_120 Vincent (ref_216) 2019; 12 ref_122 Zhao (ref_342) 2014; 307 ref_121 ref_242 ref_245 Luo (ref_88) 2022; 556 Yu (ref_168) 2018; 8 Chen (ref_78) 2016; 6 Lee (ref_109) 2014; 1842 Pan (ref_137) 2019; 129 Heo (ref_297) 2022; 12 Jehan (ref_125) 2017; 1 Ratto (ref_25) 2022; 13 Xu (ref_85) 2023; 16 Sharma (ref_112) 2024; 38 ref_71 Yu (ref_247) 2002; 277 ref_279 Byun (ref_287) 2022; 119 ref_70 Kim (ref_105) 2021; 12 Papareddy (ref_159) 2024; 15 ref_79 ref_153 ref_274 ref_77 Gurung (ref_130) 2021; 19 ref_152 Crewe (ref_190) 2022; 23 ref_276 Gu (ref_284) 2019; 20 Biobaku (ref_47) 2019; 104 ref_74 Ji (ref_196) 2019; 39 Li (ref_43) 2022; 36 ref_73 ref_156 Weikel (ref_104) 2015; 308 Li (ref_291) 2020; 10 Ru (ref_170) 2022; 43 Romero (ref_290) 2023; 77 Tanne (ref_7) 2023; 381 Gong (ref_34) 2024; 20 Mollereau (ref_72) 2014; 8 Garneau (ref_261) 2019; 45 ref_281 ref_280 Lee (ref_282) 2019; 43 Lee (ref_41) 2022; 59 Yang (ref_108) 2018; 19 ref_148 ref_147 Porto (ref_59) 2015; 23 ref_80 Donnelly (ref_268) 2005; 115 (ref_69) 2014; 27 ref_140 Ferrante (ref_244) 2013; 15 ref_89 Thomou (ref_187) 2017; 542 ref_263 Palmer (ref_204) 2019; 18 Wculek (ref_215) 2022; 19 ref_144 ref_264 ref_146 Hirsova (ref_228) 2016; 150 Fang (ref_52) 2022; 2022 Wang (ref_165) 2018; 49 Kranendonk (ref_259) 2014; 22 Khosla (ref_128) 2020; 16 Welendorf (ref_294) 2021; 13 Byrd (ref_177) 2012; 196 DeClercq (ref_189) 2015; 1851 Ting (ref_252) 2023; 12 ref_214 ref_335 Guttman (ref_131) 2013; 154 ref_213 ref_217 Grun (ref_22) 2023; 20 Yin (ref_289) 2022; 7 ref_210 (ref_13) 2022; 167 ref_212 Li (ref_163) 2020; 19 ref_211 Song (ref_270) 2021; 33 Newsholme (ref_57) 2014; 17 Johnson (ref_240) 2023; 1 Phu (ref_351) 2022; 30 Cox (ref_209) 2020; 62 ref_325 ref_328 ref_206 ref_327 ref_208 Cantini (ref_300) 2024; 48 Liu (ref_191) 2019; 181 Barnes (ref_49) 2022; 29 ref_321 Karamali (ref_81) 2024; 24 Narasimhan (ref_82) 2022; 22 Jaishy (ref_119) 2016; 57 Hu (ref_33) 2022; 36 Reinisch (ref_323) 2024; 15 Pardo (ref_200) 2018; 60 Hsiao (ref_132) 2017; 242 Solmonson (ref_91) 2016; 157 Wieser (ref_167) 2018; 67 Lee (ref_197) 2018; 46 ref_236 ref_235 ref_117 ref_238 Valentine (ref_288) 2022; 132 ref_116 Piening (ref_311) 2024; 15 ref_118 Wei (ref_149) 2021; 31 Stepanian (ref_193) 2013; 21 Donini (ref_317) 2022; 15 Santoro (ref_107) 2021; 33 ref_230 ref_350 ref_111 Hall (ref_3) 2017; 152 Li (ref_184) 2020; 12 Bruxel (ref_12) 2019; 156 Lin (ref_179) 2017; 21 Shankland (ref_32) 2023; 4 Kim (ref_241) 2016; 126 Palmer (ref_332) 2021; 162 Abbadie (ref_56) 2020; 45 Wang (ref_283) 2022; 88 Krishnan (ref_278) 2012; 26 Tan (ref_27) 2023; 24 Qiao (ref_68) 2006; 281 Victorelli (ref_76) 2023; 622 Zhang (ref_169) 2016; 8 ref_346 ref_224 ref_345 Ogawa (ref_225) 2010; 398 ref_349 Kang (ref_24) 2017; 13 Menikdiwela (ref_254) 2019; 9 Cheng (ref_35) 2020; 8 ref_220 ref_341 ref_343 Jin (ref_175) 2019; 10 Hubal (ref_299) 2017; 25 Rossiello (ref_58) 2022; 24 Ruggiero (ref_339) 2023; 45 Patel (ref_99) 2013; 5 Eguchi (ref_192) 2016; 94 Zhao (ref_139) 2021; 10 Fontana (ref_344) 2018; 176 Toumba (ref_114) 2022; 49 Kwan (ref_195) 2021; 78 Katsuumi (ref_347) 2024; 4 Wilding (ref_310) 2022; 24 Milbank (ref_348) 2021; 3 ref_14 Li (ref_198) 2019; 10 Nguyen (ref_151) 2022; 13 ref_10 Islam (ref_338) 2023; 22 Keller (ref_37) 2023; 12 Chen (ref_96) 2020; 28 Dai (ref_176) 2013; 4 Murano (ref_227) 2008; 49 ref_19 Xie (ref_226) 2018; 7 Kajimoto (ref_203) 2013; 4 Smith (ref_15) 2021; 45 Walker (ref_100) 2014; 19 Quan (ref_301) 2020; 37 Nguyen (ref_67) 2019; 597 Wood (ref_319) 2024; 114 Fang (ref_11) 2023; 45 Prado (ref_318) 2024; 20 Lykkesfeldt (ref_285) 2009; 104 ref_23 Nunn (ref_316) 2024; 80 ref_21 ref_20 Mleczko (ref_260) 2018; 62 Minster (ref_38) 2016; 48 Trauner (ref_267) 2010; 1801 Sandforth (ref_329) 2023; 11 Deng (ref_222) 2009; 58 ref_29 ref_28 (ref_93) 1990; 10 Cui (ref_86) 2020; 3 Gois (ref_320) 2023; 67 ref_26 Isaac (ref_157) 2021; 33 Yousefzadeh (ref_17) 2018; 36 Bartoszewska (ref_178) 2019; 33 Ying (ref_181) 2017; 171 Hayflick (ref_18) 1965; 37 Pfitzner (ref_143) 2020; 182 ref_315 Ye (ref_9) 2023; 108 Patry (ref_322) 2021; 22 Wang (ref_141) 2022; 601 Li (ref_87) 2021; 10 Ioannou (ref_273) 2017; 58 Santoro (ref_271) 2016; 126 Kusminski (ref_124) 2016; 15 Ishaq (ref_324) 2018; 22 Choi (ref_61) 2013; 36 Li (ref_331) 2021; 27 Khan (ref_126) 2014; 10 Verboven (ref_110) 2018; 8 ref_302 ref_306 Hurrle (ref_250) 2017; 40 ref_305 ref_307 Dickson (ref_113) 2016; 311 Gaudet (ref_182) 2016; 6 Rutkowski (ref_106) 2015; 208 Zhong (ref_314) 2022; 4 Bae (ref_303) 2019; 27 Johnston (ref_286) 2006; 3 Wen (ref_166) 2020; 28 Sun (ref_123) 2011; 121 McIlwraith (ref_239) 2023; 1810 Morino (ref_248) 2006; 55 Fabian (ref_129) 2012; 19 ref_50 Kim (ref_30) 2023; 55 Huang (ref_102) 2018; 14 Zhang (ref_336) 2024; 64 Loos (ref_39) 2022; 23 Fang (ref_162) 2016; 1 ref_55 ref_295 ref_54 Juan (ref_134) 2018; 74 ref_298 Hirsova (ref_272) 2016; 64 Serrano (ref_53) 2014; 15 Musovic (ref_115) 2022; 549 Sun (ref_75) 2015; 42 Geisler (ref_1) 2017; 71 Zhang (ref_334) 2020; 20 Bray (ref_4) 2004; 89 Deng (ref_127) 2016; 11 ref_60 Whitehead (ref_90) 2021; 12 Bhat (ref_150) 2021; 35 Verderio (ref_202) 2018; 59 ref_161 ref_164 Martini (ref_16) 2023; 290 ref_66 ref_65 Wadey (ref_188) 2019; 283 Liu (ref_293) 2020; 30 Zhang (ref_277) 2019; 1136 Beneit (ref_94) 2016; 2016 Li (ref_174) 2017; 8 ref_171 ref_292 Peng (ref_340) 2022; 13 Hawley (ref_40) 2022; 30 Saltiel (ref_101) 2001; 414 Samuel (ref_255) 2004; 279 Hue (ref_45) 2009; 297 Zhang (ref_84) 2020; 18 Braune (ref_234) 2020; 70 Lundblad (ref_97) 2021; 2021 ref_199 ref_31 Snel (ref_103) 2012; 2012 Wree (ref_262) 2013; 10 Salminen (ref_309) 2024; 102 Dores (ref_142) 2012; 23 Weisberg (ref_205) 2003; 112 Hui (ref_63) 2017; 18 Lee (ref_154) 2024; 56 Liang (ref_158) 2016; 129 List (ref_312) 2016; 4 Bosch (ref_98) 2015; 23 Gao (ref_180) 2020; 228 Johnson (ref_243) 2022; 322 Man (ref_207) 2022; 19 Song (ref_219) 2018; 48 Yoshida (ref_308) 2020; 11 Hikita (ref_265) 2018; 2 Hwang (ref_64) 2015; 5 Kietzmann (ref_36) 2017; 174 ref_46 ref_183 ref_186 ref_185 Taniyama (ref_251) 2005; 25 ref_42 Fabbrini (ref_266) 2010; 51 Hikita (ref_145) 2019; 9 Flaherty (ref_223) 2019; 363 Li (ref_194) 2019; 18 ref_2 ref_48 Elsherbini (ref_201) 2018; 140 Matacchione (ref_218) 2022; 44 Rossi (ref_313) 2019; 27 Lohrmann (ref_233) 2021; 12 ref_8 Helming (ref_232) 2009; 122 ref_5 Tanaka (ref_92) 2021; 40 Catanzaro (ref_296) 2021; 44 ref_6 |
| References_xml | – ident: ref_349 doi: 10.1016/j.bbadis.2024.167095 – ident: ref_79 doi: 10.3389/fcell.2021.674103 – volume: 279 start-page: 32345 year: 2004 ident: ref_255 article-title: Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease publication-title: J. Biol. Chem. doi: 10.1074/jbc.M313478200 – ident: ref_89 doi: 10.3390/ijms20092358 – ident: ref_302 doi: 10.3390/ncrna9050053 – volume: 42 start-page: 112866 year: 2023 ident: ref_83 article-title: Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties publication-title: Cell Rep. doi: 10.1016/j.celrep.2023.112866 – volume: 21 start-page: 585 year: 2020 ident: ref_155 article-title: RNA delivery by extracellular vesicles in mammalian cells and its applications publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-020-0251-y – volume: 9 start-page: 8481 year: 2019 ident: ref_254 article-title: Angiotensin II Increases Endoplasmic Reticulum Stress in Adipose Tissue and Adipocytes publication-title: Sci. Rep. doi: 10.1038/s41598-019-44834-8 – volume: 20 start-page: 261 year: 2024 ident: ref_318 article-title: Sarcopenic obesity in older adults: A clinical overview publication-title: Nat. Rev. Endocrinol. doi: 10.1038/s41574-023-00943-z – volume: 22 start-page: e13767 year: 2023 ident: ref_338 article-title: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age publication-title: Aging Cell doi: 10.1111/acel.13767 – ident: ref_341 doi: 10.3390/ijms24010629 – volume: 15 start-page: 482 year: 2014 ident: ref_53 article-title: Cellular senescence: From physiology to pathology publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3823 – volume: 22 start-page: 2216 year: 2014 ident: ref_259 article-title: Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells publication-title: Obesity doi: 10.1002/oby.20847 – volume: 8 start-page: 311 year: 2014 ident: ref_72 article-title: Getting the better of ER stress publication-title: J. Cell Commun. Signal doi: 10.1007/s12079-014-0251-9 – ident: ref_144 doi: 10.1083/jcb.201904113 – ident: ref_213 doi: 10.3390/ijms21155505 – volume: 21 start-page: 1091 year: 2017 ident: ref_179 article-title: microRNA-199a-5p mediates high glucose-induced reactive oxygen species production and apoptosis in INS-1 pancreatic β-cells by targeting SIRT1 publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 19 start-page: 384 year: 2022 ident: ref_215 article-title: Metabolism of tissue macrophages in homeostasis and pathology publication-title: Cell. Mol. Immunol. doi: 10.1038/s41423-021-00791-9 – ident: ref_5 doi: 10.3390/metabo13050675 – volume: 11 start-page: 798 year: 2023 ident: ref_329 article-title: Mechanisms of weight loss-induced remission in people with prediabetes: A post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS) publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(23)00235-8 – volume: 11 start-page: 421 year: 2016 ident: ref_127 article-title: Obesity, Inflammation, and Cancer publication-title: Annu. Rev. Pathol. doi: 10.1146/annurev-pathol-012615-044359 – volume: 59 start-page: 1325 year: 2018 ident: ref_202 article-title: Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles publication-title: J. Lipid Res. doi: 10.1194/jlr.R083915 – ident: ref_236 doi: 10.3389/fendo.2022.739882 – volume: 49 start-page: 1562 year: 2008 ident: ref_227 article-title: Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice publication-title: J. Lipid Res. doi: 10.1194/jlr.M800019-JLR200 – volume: 10 start-page: 7422 year: 2020 ident: ref_291 article-title: Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance between cells/tissues publication-title: Theranostics doi: 10.7150/thno.42167 – volume: 119 start-page: e2205626119 year: 2022 ident: ref_287 article-title: Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2205626119 – volume: 33 start-page: 1911 year: 2021 ident: ref_270 article-title: Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases publication-title: Cell Metab. doi: 10.1016/j.cmet.2021.09.001 – ident: ref_328 doi: 10.1097/j.pbj.0000000000000120 – volume: 10 start-page: e65108 year: 2021 ident: ref_87 article-title: Adiponectin preserves metabolic fitness during aging publication-title: Elife doi: 10.7554/eLife.65108 – ident: ref_48 – ident: ref_264 doi: 10.1016/j.jare.2024.01.027 – volume: 12 start-page: 11543 year: 2022 ident: ref_297 article-title: Adipocyte differentiation between obese and lean conditions depends on changes in miRNA expression publication-title: Sci. Rep. doi: 10.1038/s41598-022-15331-2 – volume: 19 start-page: 164 year: 2020 ident: ref_163 article-title: A review on the biology and properties of adipose tissue macrophages involved in adipose tissue physiological and pathophysiological processes publication-title: Lipids Health Dis. doi: 10.1186/s12944-020-01342-3 – volume: 14 start-page: 1483 year: 2018 ident: ref_102 article-title: The PI3K/AKT pathway in obesity and type 2 diabetes publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.27173 – volume: 10 start-page: 2375 year: 2019 ident: ref_198 article-title: Adipose HuR protects against diet-induced obesity and insulin resistance publication-title: Nat. Commun. doi: 10.1038/s41467-019-10348-0 – volume: 80 start-page: 101880 year: 2024 ident: ref_316 article-title: Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism publication-title: Mol. Metab. doi: 10.1016/j.molmet.2024.101880 – ident: ref_23 doi: 10.3389/fcell.2020.599048 – volume: 283 start-page: 19 year: 2019 ident: ref_188 article-title: Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2019.01.013 – volume: 45 start-page: 505 year: 2019 ident: ref_261 article-title: Role of myokines in the development of skeletal muscle insulin resistance and related metabolic defects in type 2 diabetes publication-title: Diabetes Metab. doi: 10.1016/j.diabet.2019.02.006 – volume: 94 start-page: 1241 year: 2016 ident: ref_192 article-title: Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress publication-title: J. Mol. Med. doi: 10.1007/s00109-016-1446-8 – ident: ref_217 doi: 10.3390/membranes12111083 – ident: ref_253 doi: 10.3390/ijms24097898 – volume: 6 start-page: 22862 year: 2016 ident: ref_182 article-title: miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity publication-title: Sci. Rep. doi: 10.1038/srep22862 – ident: ref_279 doi: 10.3390/biom10121699 – ident: ref_295 doi: 10.3390/antiox12030760 – ident: ref_238 doi: 10.3390/nu10040432 – volume: 31 start-page: 157 year: 2021 ident: ref_149 article-title: RAB31 marks and controls an ESCRT-independent exosome pathway publication-title: Cell Res. doi: 10.1038/s41422-020-00409-1 – ident: ref_280 doi: 10.3390/nu14061137 – ident: ref_31 doi: 10.20944/preprints202401.0975.v1 – volume: 57 start-page: 1619 year: 2016 ident: ref_119 article-title: Lipids, lysosomes, and autophagy publication-title: J. Lipid Res. doi: 10.1194/jlr.R067520 – volume: 5 start-page: 2019 year: 2013 ident: ref_99 article-title: Body fat distribution and insulin resistance publication-title: Nutrients doi: 10.3390/nu5062019 – ident: ref_171 doi: 10.3389/fphar.2021.614068 – volume: 126 start-page: 859 year: 2016 ident: ref_271 article-title: Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9 publication-title: J. Clin. Investig. doi: 10.1172/JCI83885 – volume: 1136 start-page: 87 year: 2019 ident: ref_277 article-title: Hypoxia and Metabolism in Metastasis publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-3-030-12734-3_6 – volume: 27 start-page: 1068 year: 2019 ident: ref_313 article-title: Weight Cycling as a Risk Factor for Low Muscle Mass and Strength in a Population of Males and Females with Obesity publication-title: Obesity doi: 10.1002/oby.22493 – volume: 28 start-page: 235 year: 2020 ident: ref_96 article-title: Endogenous Omega-3 Polyunsaturated Fatty Acids Reduce the Number and Differentiation of White Adipocyte Progenitors in Mice publication-title: Obesity doi: 10.1002/oby.22626 – ident: ref_212 doi: 10.1371/journal.pone.0105262 – ident: ref_220 doi: 10.1371/journal.pone.0123110 – volume: 51 start-page: 679 year: 2010 ident: ref_266 article-title: Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications publication-title: Hepatology doi: 10.1002/hep.23280 – volume: 30 start-page: 2468 year: 2022 ident: ref_40 article-title: The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans publication-title: Obesity doi: 10.1002/oby.23559 – volume: 44 start-page: 1941 year: 2022 ident: ref_218 article-title: Senescent macrophages in the human adipose tissue as a source of inflammaging publication-title: Geroscience doi: 10.1007/s11357-022-00536-0 – ident: ref_95 doi: 10.1016/j.jbc.2022.102716 – volume: 48 start-page: 1049 year: 2016 ident: ref_38 article-title: A thrifty variant in CREBRF strongly influences body mass index in Samoans publication-title: Nat. Genet. doi: 10.1038/ng.3620 – volume: 182 start-page: 1140 year: 2020 ident: ref_143 article-title: An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission publication-title: Cell doi: 10.1016/j.cell.2020.07.021 – volume: 18 start-page: 645 year: 2017 ident: ref_63 article-title: Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue publication-title: EMBO Rep. doi: 10.15252/embr.201643184 – volume: 18 start-page: 2067 year: 2019 ident: ref_194 article-title: Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release publication-title: Cell Cycle doi: 10.1080/15384101.2019.1638694 – volume: 398 start-page: 723 year: 2010 ident: ref_225 article-title: Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2010.07.008 – volume: 10 start-page: 493 year: 1990 ident: ref_93 article-title: “Portal” adipose tissue as a generator of risk factors for cardiovascular disease and diabetes publication-title: Arteriosclerosis doi: 10.1161/01.ATV.10.4.493 – volume: 36 start-page: 18 year: 2018 ident: ref_17 article-title: Fisetin is a senotherapeutic that extends health and lifespan publication-title: EBioMedicine doi: 10.1016/j.ebiom.2018.09.015 – ident: ref_73 doi: 10.3389/fcell.2022.822816 – ident: ref_120 doi: 10.3389/fcell.2022.817877 – volume: 6 start-page: ra88 year: 2013 ident: ref_173 article-title: Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells publication-title: Sci. Signal. doi: 10.1126/scisignal.2004512 – volume: 19 start-page: 421 year: 2022 ident: ref_207 article-title: Resident and migratory adipose immune cells control systemic metabolism and thermogenesis publication-title: Cell Mol. Immunol. doi: 10.1038/s41423-021-00804-7 – ident: ref_136 doi: 10.3389/fphys.2021.801340 – volume: 8 start-page: 505 year: 2016 ident: ref_169 article-title: Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155 publication-title: J. Mol. Cell Biol. doi: 10.1093/jmcb/mjw040 – volume: 43 start-page: 1167 year: 2022 ident: ref_170 article-title: The miR-23-27-24 cluster: An emerging target in NAFLD pathogenesis publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-021-00819-w – volume: 27 start-page: 63 year: 2014 ident: ref_69 article-title: Regulation of adipocyte lipolysis publication-title: Nutr. Res. Rev. doi: 10.1017/S095442241400002X – volume: 13 start-page: 2138 year: 2022 ident: ref_151 article-title: Secondary structure RNA elements control the cleavage activity of DICER publication-title: Nat. Commun. doi: 10.1038/s41467-022-29822-3 – volume: 112 start-page: 1796 year: 2003 ident: ref_205 article-title: Obesity is associated with macrophage accumulation in adipose tissue publication-title: J. Clin. Investig. doi: 10.1172/JCI200319246 – ident: ref_77 doi: 10.3389/fendo.2021.650158 – volume: 129 start-page: 834 year: 2019 ident: ref_137 article-title: Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation publication-title: J. Clin. Investig. doi: 10.1172/JCI123069 – volume: 49 start-page: 160 year: 2018 ident: ref_165 article-title: Exosomes from Adipose-Derived Stem Cells Promotes VEGF-C-Dependent Lymphangiogenesis by Regulating miRNA-132/TGF-β Pathway publication-title: Cell Physiol. Biochem. doi: 10.1159/000492851 – volume: 281 start-page: 39915 year: 2006 ident: ref_68 article-title: SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex publication-title: J. Biol. Chem. doi: 10.1074/jbc.M607215200 – volume: 1842 start-page: 473 year: 2014 ident: ref_109 article-title: Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2013.05.029 – ident: ref_242 doi: 10.3390/cells11213443 – volume: 57 start-page: 1035 year: 2023 ident: ref_326 article-title: Dose-response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: A systematic review and meta-analysis of randomised controlled trials publication-title: Br. J. Sports Med. doi: 10.1136/bjsports-2022-106304 – volume: 62 start-page: 1700917 year: 2018 ident: ref_260 article-title: Extracellular Vesicles from Hypoxic Adipocytes and Obese Subjects Reduce Insulin-Stimulated Glucose Uptake publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.201700917 – volume: 45 start-page: 934 year: 2021 ident: ref_15 article-title: Cellular senescence and its role in white adipose tissue publication-title: Int. J. Obes. doi: 10.1038/s41366-021-00757-x – volume: 3 start-page: 35 year: 2006 ident: ref_286 article-title: Marginal vitamin C status is associated with reduced fat oxidation during submaximal exercise in young adults publication-title: Nutr. Metab. doi: 10.1186/1743-7075-3-35 – volume: 167 start-page: 111896 year: 2022 ident: ref_13 article-title: Relationship between heat shock proteins and cellular resistance to drugs and ageing publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2022.111896 – ident: ref_20 doi: 10.1016/j.redox.2022.102410 – volume: 597 start-page: 467 year: 2019 ident: ref_67 article-title: SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding publication-title: J. Physiol. doi: 10.1113/JP276957 – volume: 1851 start-page: 1123 year: 2015 ident: ref_189 article-title: Fatty acids increase adiponectin secretion through both classical and exosome pathways publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2015.04.005 – volume: 18 start-page: e12950 year: 2019 ident: ref_204 article-title: Targeting senescent cells alleviates obesity-induced metabolic dysfunction publication-title: Aging Cell doi: 10.1111/acel.12950 – ident: ref_210 doi: 10.3389/fimmu.2022.977485 – ident: ref_292 doi: 10.3389/fendo.2019.00038 – volume: 13 start-page: 468 year: 2022 ident: ref_340 article-title: Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases publication-title: Aging Dis. doi: 10.14336/AD.2021.0928 – volume: 601 start-page: 446 year: 2022 ident: ref_141 article-title: MicroRNA sequence codes for small extracellular vesicle release and cellular retention publication-title: Nature doi: 10.1038/s41586-021-04234-3 – ident: ref_55 doi: 10.3389/fimmu.2022.1019313 – volume: 42 start-page: 105 year: 2015 ident: ref_75 article-title: Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes publication-title: Mol. Aspects Med. doi: 10.1016/j.mam.2015.01.001 – volume: 77 start-page: 256 year: 2023 ident: ref_290 article-title: Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice publication-title: Metab. Eng. doi: 10.1016/j.ymben.2023.04.010 – volume: 10 start-page: 2234 year: 2014 ident: ref_126 article-title: ER stress in adipocytes and insulin resistance: Mechanisms and significance publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2014.2532 – ident: ref_71 doi: 10.3390/cells8091071 – volume: 242 start-page: 1136 year: 2017 ident: ref_132 article-title: Circular RNA—New member of noncoding RNA with novel functions publication-title: Exp. Biol. Med. doi: 10.1177/1535370217708978 – volume: 308 start-page: C249 year: 2015 ident: ref_104 article-title: Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00265.2014 – volume: 22 start-page: 555 year: 2018 ident: ref_324 article-title: Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissue publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-017-0968-2 – volume: 16 start-page: 263 year: 2020 ident: ref_128 article-title: The role of cellular senescence in ageing and endocrine disease publication-title: Nat. Rev. Endocrinol. doi: 10.1038/s41574-020-0335-y – volume: 39 start-page: e00508-18 year: 2019 ident: ref_196 article-title: RNA Binding Protein HuR Promotes Autophagosome Formation by Regulating Expression of Autophagy-Related Proteins 5, 12, and 16 in Human Hepatocellular Carcinoma Cells publication-title: Mol. Cell Biol. doi: 10.1128/MCB.00508-18 – volume: 277 start-page: 50230 year: 2002 ident: ref_247 article-title: Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle publication-title: J. Biol. Chem. doi: 10.1074/jbc.M200958200 – ident: ref_274 doi: 10.3390/vaccines11020261 – volume: 208 start-page: 501 year: 2015 ident: ref_106 article-title: The cell biology of fat expansion publication-title: J. Cell Biol. doi: 10.1083/jcb.201409063 – volume: 67 start-page: 157 year: 2018 ident: ref_167 article-title: Adipose type I interferon signalling protects against metabolic dysfunction publication-title: Gut doi: 10.1136/gutjnl-2016-313155 – volume: 13 start-page: 616 year: 2017 ident: ref_24 article-title: Chemical screening identifies ATM as a target for alleviating senescence publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2342 – volume: 19 start-page: 57 year: 2014 ident: ref_100 article-title: The pathophysiology of abdominal adipose tissue depots in health and disease publication-title: Horm. Mol. Biol. Clin. Investig. doi: 10.1515/hmbci-2014-0023 – volume: 26 start-page: 259 year: 2012 ident: ref_278 article-title: Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system publication-title: Genes. Dev. doi: 10.1101/gad.180406.111 – volume: 157 start-page: 455 year: 2016 ident: ref_91 article-title: Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis publication-title: Endocrinology doi: 10.1210/en.2015-1803 – ident: ref_122 doi: 10.1371/journal.pone.0198889 – volume: 55 start-page: S9 year: 2006 ident: ref_248 article-title: Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links with Mitochondrial Dysfunction publication-title: Diabetes doi: 10.2337/db06-S002 – ident: ref_307 doi: 10.1371/journal.pone.0252547 – volume: 414 start-page: 799 year: 2001 ident: ref_101 article-title: Insulin signalling and the regulation of glucose and lipid metabolism publication-title: Nature doi: 10.1038/414799a – volume: 12 start-page: 2194034 year: 2023 ident: ref_252 article-title: In vitro studies of the renin-angiotensin system in human adipose tissue/adipocytes and possible relationship to SARS-CoV-2: A scoping review publication-title: Adipocyte doi: 10.1080/21623945.2023.2194034 – volume: 8 start-page: e2699 year: 2017 ident: ref_174 article-title: Upregulation of miR-665 promotes apoptosis and colitis in inflammatory bowel disease by repressing the endoplasmic reticulum stress components XBP1 and ORMDL3 publication-title: Cell Death Dis. doi: 10.1038/cddis.2017.76 – volume: 25 start-page: 1142 year: 2005 ident: ref_251 article-title: Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000164313.17167.df – ident: ref_257 doi: 10.3390/biom10040534 – ident: ref_263 doi: 10.3390/ijms232012185 – volume: 89 start-page: 2583 year: 2004 ident: ref_4 article-title: Medical Consequences of Obesity publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2004-0535 – volume: 290 start-page: 1186 year: 2023 ident: ref_16 article-title: Cellular senescence: All roads lead to mitochondria publication-title: Febs J. doi: 10.1111/febs.16361 – ident: ref_19 doi: 10.3389/fphys.2021.627837 – ident: ref_146 doi: 10.3390/cells11040746 – volume: 3 start-page: e67 year: 2022 ident: ref_330 article-title: The costs and benefits of senotherapeutics for human health publication-title: Lancet Healthy Longev. doi: 10.1016/S2666-7568(21)00300-7 – ident: ref_21 doi: 10.3389/fendo.2022.957616 – volume: 24 start-page: 135 year: 2022 ident: ref_58 article-title: Telomere dysfunction in ageing and age-related diseases publication-title: Nat. Cell Biol. doi: 10.1038/s41556-022-00842-x – ident: ref_327 doi: 10.3389/fphys.2020.00091 – ident: ref_214 doi: 10.3389/fnut.2021.625331 – ident: ref_164 doi: 10.3390/cells11081336 – ident: ref_235 doi: 10.1186/s12915-021-01181-3 – volume: 67 start-page: e000631 year: 2023 ident: ref_320 article-title: Dietary inflammatory index and its relation to the pathophysiological aspects of obesity: A narrative review publication-title: Arch. Endocrinol. Metab. doi: 10.20945/2359-3997000000631 – volume: 322 start-page: R347 year: 2022 ident: ref_243 article-title: Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00238.2021 – ident: ref_10 doi: 10.1038/s41574-024-01008-5 – volume: 156 start-page: 33 year: 2019 ident: ref_12 article-title: Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice publication-title: Biochimie doi: 10.1016/j.biochi.2018.09.011 – volume: 36 start-page: e22266 year: 2022 ident: ref_33 article-title: cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress publication-title: Faseb J. doi: 10.1096/fj.202101988R – volume: 4 start-page: 1713 year: 2022 ident: ref_314 article-title: High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption publication-title: Nat. Metab. doi: 10.1038/s42255-022-00687-6 – volume: 196 start-page: 689 year: 2012 ident: ref_177 article-title: MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response publication-title: J. Cell Biol. doi: 10.1083/jcb.201201077 – volume: 114 start-page: 60 year: 2024 ident: ref_319 article-title: Impact of EASO/ESPEN-Defined Sarcopenic Obesity Following a Technology-Based Weight Loss Intervention publication-title: Calcif. Tissue Int. doi: 10.1007/s00223-023-01138-4 – volume: 45 start-page: 2785 year: 2023 ident: ref_339 article-title: Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: Implications for senolytic clinical trial design publication-title: Geroscience doi: 10.1007/s11357-023-00830-5 – ident: ref_199 doi: 10.3389/fimmu.2022.824188 – volume: 71 start-page: 1256 year: 2017 ident: ref_1 article-title: Defining obesity as a disease publication-title: Eur. J. Clin. Nutr. doi: 10.1038/ejcn.2017.155 – ident: ref_111 doi: 10.3389/fphys.2022.826314 – volume: 55 start-page: 510 year: 2023 ident: ref_30 article-title: Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway publication-title: Exp. Mol. Med. doi: 10.1038/s12276-023-00965-7 – volume: 20 start-page: 152 year: 2024 ident: ref_34 article-title: The Role of cGAS-STING Signalling in Metabolic Diseases: From Signalling Networks to Targeted Intervention publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.84890 – volume: 36 start-page: e22611 year: 2022 ident: ref_43 article-title: Generation of a genetically modified pig model with CREBRF(R457Q) variant publication-title: Faseb J. doi: 10.1096/fj.202201117 – volume: 4 start-page: 2712 year: 2013 ident: ref_203 article-title: Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes publication-title: Nat. Commun. doi: 10.1038/ncomms3712 – ident: ref_211 doi: 10.3389/fimmu.2019.01462 – volume: 10 start-page: 627 year: 2013 ident: ref_262 article-title: From NAFLD to NASH to cirrhosis—New insights into disease mechanisms publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/nrgastro.2013.149 – volume: 20 start-page: 280 year: 2020 ident: ref_334 article-title: Quercetin modulates AMPK/SIRT1/NF-κB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat diet-induced atherosclerosis in the rat carotid artery publication-title: Exp. Ther. Med. doi: 10.3892/etm.2020.9410 – volume: 4 start-page: e604 year: 2013 ident: ref_176 article-title: microRNA-199a-5p protects hepatocytes from bile acid-induced sustained endoplasmic reticulum stress publication-title: Cell Death Dis. doi: 10.1038/cddis.2013.134 – volume: 311 start-page: R79 year: 2016 ident: ref_113 article-title: Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00114.2016 – ident: ref_46 doi: 10.3390/antiox11071336 – volume: 74 start-page: 66 year: 2018 ident: ref_134 article-title: Biogenesis and function of ESCRT-dependent extracellular vesicles publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2017.08.022 – volume: 25 start-page: 8820 year: 2019 ident: ref_62 article-title: Tumor Necrosis Factor-alpha (TNF-α) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1) publication-title: Med. Sci. Monit. doi: 10.12659/MSM.919721 – volume: 36 start-page: 385 year: 2013 ident: ref_61 article-title: Regulation of SIRT1 by microRNAs publication-title: Mol. Cells doi: 10.1007/s10059-013-0297-1 – volume: 28 start-page: 1932 year: 2020 ident: ref_166 article-title: Hypertrophic Adipocyte-Derived Exosomal miR-802-5p Contributes to Insulin Resistance in Cardiac Myocytes Through Targeting HSP60 publication-title: Obesity doi: 10.1002/oby.22932 – ident: ref_346 doi: 10.3389/fphar.2022.838277 – volume: 187 start-page: 111229 year: 2020 ident: ref_51 article-title: Oncogene-induced senescence: From biology to therapy publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2020.111229 – ident: ref_2 – volume: 297 start-page: E578 year: 2009 ident: ref_45 article-title: The Randle cycle revisited: A new head for an old hat publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00093.2009 – ident: ref_249 doi: 10.3390/ijms23116048 – volume: 2012 start-page: 983814 year: 2012 ident: ref_103 article-title: Ectopic fat and insulin resistance: Pathophysiology and effect of diet and lifestyle interventions publication-title: Int. J. Endocrinol. doi: 10.1155/2012/983814 – volume: 181 start-page: 854 year: 2019 ident: ref_191 article-title: Adipose stem cell-derived exosomes in combination with hyaluronic acid accelerate wound healing through enhancing re-epithelialization and vascularization publication-title: Br. J. Dermatol. doi: 10.1111/bjd.17984 – volume: 78 start-page: 7275 year: 2021 ident: ref_195 article-title: The impact of obesity on adipocyte-derived extracellular vesicles publication-title: Cell Mol. Life Sci. doi: 10.1007/s00018-021-03973-w – volume: 13 start-page: 4848 year: 2022 ident: ref_25 article-title: Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly publication-title: Nat. Commun. doi: 10.1038/s41467-022-32515-6 – volume: 129 start-page: 2182 year: 2016 ident: ref_158 article-title: Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a publication-title: J. Cell Sci. doi: 10.1242/jcs.170373 – volume: 1 start-page: 00019 year: 2017 ident: ref_125 article-title: Obstructive Sleep Apnea and Obesity: Implications for Public Health publication-title: Sleep Med. Disord. – ident: ref_315 doi: 10.1038/s41591-023-02614-y – volume: 8 start-page: e001372 year: 2020 ident: ref_35 article-title: Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1-mediated immunoescape via STING-IFN signaling and extracellular vesicles publication-title: J. Immunother. Cancer doi: 10.1136/jitc-2020-001372 – ident: ref_42 doi: 10.3390/cells11030497 – volume: 2016 start-page: 1216783 year: 2016 ident: ref_94 article-title: Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications publication-title: Int. J. Endocrinol. – volume: 171 start-page: 372 year: 2017 ident: ref_181 article-title: Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity publication-title: Cell doi: 10.1016/j.cell.2017.08.035 – volume: 126 start-page: 4372 year: 2016 ident: ref_241 article-title: ChREBP regulates fructose-induced glucose production independently of insulin signaling publication-title: J. Clin. Investig. doi: 10.1172/JCI81993 – volume: 20 start-page: 2450 year: 2019 ident: ref_284 article-title: Ascorbic acid attenuates cell stress by activating the fibroblast growth factor 21/fibroblast growth factor receptor 2/adiponectin pathway in HepG2 cells publication-title: Mol. Med. Rep. – volume: 22 start-page: 266 year: 2021 ident: ref_322 article-title: Fiber-poor Western diets fuel inflammation publication-title: Nat. Immunol. doi: 10.1038/s41590-021-00880-x – volume: 1801 start-page: 299 year: 2010 ident: ref_267 article-title: Fatty liver and lipotoxicity publication-title: Biochim. Et Biophys. Acta (BBA) Mol. Cell Biol. Lipids – volume: 20 start-page: 51 year: 2023 ident: ref_22 article-title: Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis publication-title: Immun. Ageing doi: 10.1186/s12979-023-00378-0 – ident: ref_117 – volume: 1 start-page: e89908 year: 2016 ident: ref_162 article-title: Adipocyte-specific loss of PPARγ attenuates cardiac hypertrophy publication-title: JCI Insight doi: 10.1172/jci.insight.89908 – ident: ref_325 doi: 10.3390/ijms24076192 – volume: 108 start-page: 2240 year: 2023 ident: ref_9 article-title: The Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgad152 – volume: 1 start-page: 646 year: 2015 ident: ref_172 article-title: Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ publication-title: Cell Mol. Gastroenterol. Hepatol. doi: 10.1016/j.jcmgh.2015.07.007 – volume: 45 start-page: 2835 year: 2023 ident: ref_11 article-title: Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment publication-title: Geroscience doi: 10.1007/s11357-023-00843-0 – volume: 122 start-page: 453 year: 2009 ident: ref_232 article-title: The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion publication-title: J. Cell Sci. doi: 10.1242/jcs.037200 – volume: 23 start-page: 120 year: 2022 ident: ref_39 article-title: The genetics of obesity: From discovery to biology publication-title: Nat. Rev. Genet. doi: 10.1038/s41576-021-00414-z – volume: 4 start-page: 926 year: 2024 ident: ref_347 article-title: SGLT2 inhibition eliminates senescent cells and alleviates pathological aging publication-title: Nat. Aging doi: 10.1038/s43587-024-00642-y – ident: ref_28 doi: 10.3390/ijms222413384 – volume: 2021 start-page: 6634536 year: 2021 ident: ref_97 article-title: Reference Values for DXA-Derived Visceral Adipose Tissue in Adults 40 Years and Older from a European Population: The Tromsø Study 2015–2016 publication-title: J. Obes. doi: 10.1155/2021/6634536 – volume: 109 start-page: 858 year: 2024 ident: ref_258 article-title: Circulating miRNAs Detect High vs. Low Visceral Adipose Tissue Inflammation in Patients Living With Obesity publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/clinem/dgad550 – volume: 49 start-page: 10 year: 2022 ident: ref_114 article-title: Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2021.5065 – ident: ref_147 doi: 10.3390/ijms24021337 – volume: 15 start-page: 34 year: 2013 ident: ref_244 article-title: The immune cells in adipose tissue publication-title: Diabetes Obes. Metab. doi: 10.1111/dom.12154 – ident: ref_118 doi: 10.3390/ijms18061321 – volume: 104 start-page: 6118 year: 2019 ident: ref_47 article-title: Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2018-01833 – volume: 48 start-page: 1416 year: 2018 ident: ref_219 article-title: Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways publication-title: Cell. Physiol. Biochem. doi: 10.1159/000492252 – ident: ref_276 doi: 10.3390/cells9122598 – volume: 102 start-page: 733 year: 2024 ident: ref_309 article-title: The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases publication-title: J. Mol. Med. doi: 10.1007/s00109-024-02444-6 – volume: 4 start-page: 1784 year: 2023 ident: ref_32 article-title: Podocyte Senescence and Aging publication-title: Kidney360 doi: 10.34067/KID.0000000000000284 – volume: 622 start-page: 627 year: 2023 ident: ref_76 article-title: Apoptotic stress causes mtDNA release during senescence and drives the SASP publication-title: Nature doi: 10.1038/s41586-023-06621-4 – volume: 132 start-page: e153357 year: 2022 ident: ref_288 article-title: β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity publication-title: J. Clin. Investig. doi: 10.1172/JCI153357 – volume: 12 start-page: 482 year: 2023 ident: ref_37 article-title: Genetics and Epigenetics in Obesity: What Do We Know so Far? publication-title: Curr. Obes. Rep. doi: 10.1007/s13679-023-00526-z – volume: 15 start-page: 639 year: 2016 ident: ref_124 article-title: Targeting adipose tissue in the treatment of obesity-associated diabetes publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd.2016.75 – volume: 45 start-page: 371 year: 2020 ident: ref_56 article-title: Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2020.02.005 – ident: ref_138 doi: 10.3389/fimmu.2018.00738 – volume: 18 start-page: 60 year: 2020 ident: ref_84 article-title: Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor publication-title: Cell Commun. Signal doi: 10.1186/s12964-020-00546-5 – volume: 27 start-page: 1941 year: 2021 ident: ref_331 article-title: Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce publication-title: Nat. Med. doi: 10.1038/s41591-021-01501-8 – volume: 18 start-page: 816 year: 2013 ident: ref_229 article-title: Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation publication-title: Cell Metab. doi: 10.1016/j.cmet.2013.11.001 – ident: ref_224 doi: 10.3389/fcvm.2023.1046495 – volume: 64 start-page: 2219 year: 2016 ident: ref_272 article-title: Extracellular vesicles in liver pathobiology: Small particles with big impact publication-title: Hepatology doi: 10.1002/hep.28814 – volume: 2022 start-page: 7175027 year: 2022 ident: ref_52 article-title: Transmissible Endoplasmic Reticulum Stress Mediated by Extracellular Vesicles from Adipocyte Promoting the Senescence of Adipose-Derived Mesenchymal Stem Cells in Hypertrophic Obesity publication-title: Oxid. Med. Cell Longev. doi: 10.1155/2022/7175027 – volume: 12 start-page: 2027 year: 2021 ident: ref_233 article-title: Monocyte progenitors give rise to multinucleated giant cells publication-title: Nat. Commun. doi: 10.1038/s41467-021-22103-5 – volume: 12 start-page: 1822 year: 2021 ident: ref_105 article-title: Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver publication-title: Nat. Commun. doi: 10.1038/s41467-021-22106-2 – ident: ref_148 doi: 10.1002/jex2.96 – volume: 8 start-page: 2171 year: 2018 ident: ref_168 article-title: Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ publication-title: Theranostics doi: 10.7150/thno.22565 – ident: ref_70 doi: 10.3390/cells10020233 – volume: 59 start-page: 101464 year: 2022 ident: ref_41 article-title: The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition publication-title: Mol. Metab. doi: 10.1016/j.molmet.2022.101464 – ident: ref_345 doi: 10.3390/nu11122923 – volume: 6 start-page: 27486 year: 2016 ident: ref_78 article-title: Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity publication-title: Sci. Rep. doi: 10.1038/srep27486 – volume: 24 start-page: 1553 year: 2022 ident: ref_310 article-title: Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension publication-title: Diabetes Obes. Metab. doi: 10.1111/dom.14725 – volume: 12 start-page: 1905 year: 2021 ident: ref_90 article-title: Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis publication-title: Nat. Commun. doi: 10.1038/s41467-021-22272-3 – volume: 307 start-page: C1130 year: 2014 ident: ref_342 article-title: Exendin-4 alleviates angiotensin II-induced senescence in vascular smooth muscle cells by inhibiting Rac1 activation via a cAMP/PKA-dependent pathway publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00151.2014 – volume: 10 start-page: 587 year: 2021 ident: ref_139 article-title: Composition, isolation, identification and function of adipose tissue-derived exosomes publication-title: Adipocyte doi: 10.1080/21623945.2021.1983242 – volume: 140 start-page: 121 year: 2018 ident: ref_201 article-title: Ceramide and exosomes: A novel target in cancer biology and therapy publication-title: Adv. Cancer Res. doi: 10.1016/bs.acr.2018.05.004 – volume: 15 start-page: 2835 year: 2024 ident: ref_311 article-title: Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk publication-title: Nat. Commun. doi: 10.1038/s41467-024-47359-5 – volume: 30 start-page: 1392 year: 2020 ident: ref_293 article-title: Adiponectin/SIRT1 Axis Induces White Adipose Browning After Vertical Sleeve Gastrectomy of Obese Rats with Type 2 Diabetes publication-title: Obes. Surg. doi: 10.1007/s11695-019-04295-4 – ident: ref_153 doi: 10.1186/s12929-023-00964-w – ident: ref_305 doi: 10.3389/fimmu.2022.984859 – volume: 154 start-page: 240 year: 2013 ident: ref_131 article-title: Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins publication-title: Cell doi: 10.1016/j.cell.2013.06.009 – volume: 115 start-page: 1343 year: 2005 ident: ref_268 article-title: Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease publication-title: J. Clin. Investig. doi: 10.1172/JCI23621 – ident: ref_306 doi: 10.3389/fimmu.2022.1044737 – volume: 381 start-page: 1400 year: 2023 ident: ref_7 article-title: Obesity: Avoid using BMI alone when evaluating patients, say US doctors’ leaders publication-title: BMJ doi: 10.1136/bmj.p1400 – volume: 33 start-page: 748 year: 2021 ident: ref_107 article-title: Insulin action in adipocytes, adipose remodeling, and systemic effects publication-title: Cell Metab. doi: 10.1016/j.cmet.2021.03.019 – volume: 542 start-page: 450 year: 2017 ident: ref_187 article-title: Adipose-derived circulating miRNAs regulate gene expression in other tissues publication-title: Nature doi: 10.1038/nature21365 – volume: 115 start-page: 12158 year: 2018 ident: ref_160 article-title: Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1808855115 – volume: 64 start-page: 4016 year: 2024 ident: ref_336 article-title: Nutritional activities of luteolin in obesity and associated metabolic diseases: An eye on adipose tissues publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2022.2138257 – ident: ref_80 doi: 10.3389/fragi.2021.790702 – volume: 19 start-page: 47 year: 2021 ident: ref_130 article-title: The exosome journey: From biogenesis to uptake and intracellular signalling publication-title: Cell Commun. Signal. doi: 10.1186/s12964-021-00730-1 – volume: 4 start-page: 95 year: 2016 ident: ref_312 article-title: Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice publication-title: Nutr. Healthy Aging doi: 10.3233/NHA-1614 – volume: 11 start-page: 23237 year: 2021 ident: ref_333 article-title: Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence publication-title: Sci. Rep. doi: 10.1038/s41598-021-02544-0 – volume: 363 start-page: 989 year: 2019 ident: ref_223 article-title: A lipase-independent pathway of lipid release and immune modulation by adipocytes publication-title: Science doi: 10.1126/science.aaw2586 – ident: ref_74 doi: 10.1101/cshperspect.a041247 – volume: 22 start-page: 537 year: 2022 ident: ref_82 article-title: Cellular Senescence in Obesity and Associated Complications: A New Therapeutic Target publication-title: Curr. Diabetes Rep. doi: 10.1007/s11892-022-01493-w – volume: 37 start-page: 614 year: 1965 ident: ref_18 article-title: The limited in vitro lifetime of human diploid cell strains publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(65)90211-9 – ident: ref_350 doi: 10.3390/ijms232314920 – volume: 11 start-page: 2482 year: 2020 ident: ref_308 article-title: The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice publication-title: Nat. Commun. doi: 10.1038/s41467-020-16347-w – volume: 23 start-page: 120 year: 2015 ident: ref_59 article-title: Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression publication-title: Obesity doi: 10.1002/oby.20919 – volume: 9 start-page: 3265 year: 2019 ident: ref_145 article-title: Src in endosomal membranes promotes exosome secretion and tumor progression publication-title: Sci. Rep. doi: 10.1038/s41598-019-39882-z – ident: ref_161 doi: 10.1371/journal.pone.0165962 – volume: 35 start-page: e21732 year: 2021 ident: ref_150 article-title: Regulatory role of mammalian target of rapamycin signaling in exosome secretion and osteogenic changes in smooth muscle cells lacking acid ceramidase gene publication-title: Faseb J. doi: 10.1096/fj.202100385R – volume: 549 start-page: 111619 year: 2022 ident: ref_115 article-title: Noradrenaline and ATP regulate adiponectin exocytosis in white adipocytes: Disturbed adrenergic and purinergic signalling in obese and insulin-resistant mice publication-title: Mol. Cell Endocrinol. doi: 10.1016/j.mce.2022.111619 – volume: 63 start-page: 731 year: 2016 ident: ref_275 article-title: Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes publication-title: Hepatology doi: 10.1002/hep.28252 – volume: 23 start-page: 61 year: 2022 ident: ref_190 article-title: Intercellular and interorgan crosstalk through adipocyte extracellular vesicles publication-title: Rev. Endocr. Metab. Disord. doi: 10.1007/s11154-020-09625-x – ident: ref_140 doi: 10.3389/fendo.2022.873865 – ident: ref_50 doi: 10.1002/bies.201600235 – volume: 24 start-page: 1717 year: 2013 ident: ref_44 article-title: Antioxidant system response is modified by dietary fat in adipose tissue of metabolic syndrome patients publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2013.02.012 – volume: 12 start-page: 22719 year: 2020 ident: ref_184 article-title: Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance publication-title: Aging – ident: ref_230 doi: 10.3390/ijms22084039 – volume: 5 start-page: 15971 year: 2015 ident: ref_64 article-title: Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia publication-title: Sci. Rep. doi: 10.1038/srep15971 – ident: ref_116 doi: 10.3390/ijms222413529 – volume: 367 start-page: 367 year: 2020 ident: ref_135 article-title: The biology, function, and biomedical applications of exosomes publication-title: Science doi: 10.1126/science.aau6977 – ident: ref_246 doi: 10.3389/fendo.2019.00577 – volume: 104 start-page: 419 year: 2009 ident: ref_285 article-title: Role of Marginal Vitamin C Deficiency in Atherogenesis: In Vivo Models and Clinical Studies publication-title: Basic Clin. Pharmacol. Toxicol. doi: 10.1111/j.1742-7843.2009.00420.x – ident: ref_152 doi: 10.3389/fcell.2020.616161 – volume: 19 start-page: 654 year: 2018 ident: ref_108 article-title: Metabolites as regulators of insulin sensitivity and metabolism publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-018-0044-8 – volume: 12 start-page: 275 year: 2019 ident: ref_216 article-title: ATP-binding cassette transporter A1 (ABCA1) expression in adipose tissue and its modulation with insulin resistance in obesity publication-title: Diabetes Metab. Syndr. Obes. doi: 10.2147/DMSO.S186565 – volume: 88 start-page: 104901 year: 2022 ident: ref_283 article-title: Ascorbic acid inhibits transcriptional activities of LXRα to ameliorate lipid metabolism disorder publication-title: J. Funct. Foods doi: 10.1016/j.jff.2021.104901 – volume: 29 start-page: 639 year: 2022 ident: ref_49 article-title: Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/s41594-022-00790-y – volume: 556 start-page: 111740 year: 2022 ident: ref_88 article-title: Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes publication-title: Mol. Cell Endocrinol. doi: 10.1016/j.mce.2022.111740 – ident: ref_245 doi: 10.3390/cells8030214 – ident: ref_121 doi: 10.1186/s12916-022-02672-y – volume: 60 start-page: 81 year: 2018 ident: ref_200 article-title: Extracellular vesicles in obesity and diabetes mellitus publication-title: Mol. Aspects Med. doi: 10.1016/j.mam.2017.11.010 – ident: ref_8 doi: 10.1371/journal.pone.0180614 – volume: 13 start-page: 19 year: 2021 ident: ref_294 article-title: Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity publication-title: Diabetol. Metab. Syndr. doi: 10.1186/s13098-021-00623-w – volume: 33 start-page: 1744 year: 2021 ident: ref_157 article-title: Exosomes as mediators of intercellular crosstalk in metabolism publication-title: Cell Metab. doi: 10.1016/j.cmet.2021.08.006 – volume: 46 start-page: 2347 year: 2005 ident: ref_231 article-title: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans publication-title: J. Lipid Res. doi: 10.1194/jlr.M500294-JLR200 – volume: 25 start-page: 102 year: 2017 ident: ref_299 article-title: Circulating adipocyte-derived exosomal MicroRNAs associated with decreased insulin resistance after gastric bypass publication-title: Obesity doi: 10.1002/oby.21709 – volume: 30 start-page: 2274 year: 2022 ident: ref_351 article-title: IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2022.03.008 – volume: 116 start-page: 1494 year: 2006 ident: ref_221 article-title: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity publication-title: J. Clin. Investig. doi: 10.1172/JCI26498 – volume: 228 start-page: e13339 year: 2020 ident: ref_180 article-title: Adipocyte-derived extracellular vesicles modulate appetite and weight through mTOR signalling in the hypothalamus publication-title: Acta Physiol. doi: 10.1111/apha.13339 – ident: ref_156 doi: 10.3389/fbioe.2022.948959 – volume: 152 start-page: 1718 year: 2017 ident: ref_3 article-title: Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.01.052 – volume: 40 start-page: 257 year: 2017 ident: ref_250 article-title: The etiology of oxidative stress in insulin resistance publication-title: Biomed. J. doi: 10.1016/j.bj.2017.06.007 – volume: 15 start-page: 321 year: 2022 ident: ref_317 article-title: Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement publication-title: Obes. Facts doi: 10.1159/000521241 – ident: ref_208 doi: 10.3390/ijms23169252 – volume: 48 start-page: 247 year: 2024 ident: ref_300 article-title: Visceral adipose tissue adiponectin predicts excess weight loss after bariatric surgery in females with severe obesity publication-title: Int. J. Obes. doi: 10.1038/s41366-023-01406-1 – volume: 1 start-page: 12 year: 2023 ident: ref_240 article-title: The fructose survival hypothesis as a mechanism for unifying the various obesity hypotheses publication-title: Obesity – volume: 15 start-page: 1150 year: 2024 ident: ref_159 article-title: The role of extracellular vesicle fusion with target cells in triggering systemic inflammation publication-title: Nat. Commun. doi: 10.1038/s41467-024-45125-1 – ident: ref_133 doi: 10.3390/cancers13051157 – volume: 58 start-page: 1067 year: 2017 ident: ref_273 article-title: Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH publication-title: J. Lipid Res. doi: 10.1194/jlr.M072454 – volume: 31 start-page: 1610 year: 2023 ident: ref_304 article-title: Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss publication-title: Obesity doi: 10.1002/oby.23745 – ident: ref_186 doi: 10.1016/j.bbapap.2018.11.009 – ident: ref_206 doi: 10.3390/cells11091424 – ident: ref_65 doi: 10.3389/fphys.2021.733453 – volume: 56 start-page: 877 year: 2024 ident: ref_154 article-title: Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer publication-title: Exp. Mol. Med. doi: 10.1038/s12276-024-01209-y – volume: 23 start-page: 3612 year: 2012 ident: ref_142 article-title: AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e12-03-0251 – ident: ref_256 doi: 10.3389/fphar.2023.1188829 – ident: ref_54 doi: 10.3390/nu15030703 – ident: ref_29 doi: 10.3390/ijms19051327 – volume: 162 start-page: bqab058 year: 2021 ident: ref_332 article-title: Senolytics: Potential for Alleviating Diabetes and Its Complications publication-title: Endocrinology doi: 10.1210/endocr/bqab058 – volume: 121 start-page: 2094 year: 2011 ident: ref_123 article-title: Adipose tissue remodeling and obesity publication-title: J. Clin. Investig. doi: 10.1172/JCI45887 – volume: 21 start-page: 2236 year: 2013 ident: ref_193 article-title: Microparticle increase in severe obesity: Not related to metabolic syndrome and unchanged after massive weight loss publication-title: Obesity doi: 10.1002/oby.20365 – volume: 62 start-page: 1 year: 2020 ident: ref_209 article-title: Macrophage ontogeny in the control of adipose tissue biology publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2019.08.002 – volume: 40 start-page: 3479 year: 2021 ident: ref_92 article-title: Distinct associations of intraperitoneal and retroperitoneal visceral adipose tissues with metabolic syndrome and its components publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2020.11.030 – volume: 24 start-page: 104 year: 2024 ident: ref_81 article-title: Decoding contextual crosstalk: Revealing distinct interactions between non-coding RNAs and unfolded protein response in breast cancer publication-title: Cancer Cell Int. doi: 10.1186/s12935-024-03296-3 – volume: 12 start-page: 11337 year: 2020 ident: ref_337 article-title: Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin publication-title: Aging doi: 10.18632/aging.103607 – volume: 24 start-page: e57265 year: 2023 ident: ref_27 article-title: Lysosomes in senescence and aging publication-title: EMBO Rep. doi: 10.15252/embr.202357265 – volume: 3 start-page: 178 year: 2020 ident: ref_86 article-title: Adiponectin attenuates the premature senescence of vascular smooth muscle cells induced by high glucose through mTOR signaling pathway publication-title: Aging Med. doi: 10.1002/agm2.12106 – ident: ref_281 doi: 10.3390/nu12082348 – volume: 3 start-page: 1415 year: 2021 ident: ref_348 article-title: Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation publication-title: Nat. Metab. doi: 10.1038/s42255-021-00467-8 – volume: 37 start-page: 221 year: 2020 ident: ref_301 article-title: Exosomal Secretion of Adipose Tissue during Various Physiological States publication-title: Pharm. Res. doi: 10.1007/s11095-020-02941-6 – volume: 26 start-page: 19 year: 2005 ident: ref_269 article-title: Insulin and insulin resistance publication-title: Clin. Biochem. Rev. – volume: 150 start-page: 956 year: 2016 ident: ref_228 article-title: Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.12.037 – volume: 44 start-page: 1159 year: 2021 ident: ref_296 article-title: Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies publication-title: J. Endocrinol. Invest. doi: 10.1007/s40618-020-01453-9 – volume: 2 start-page: 120 year: 2018 ident: ref_265 article-title: Mechanisms of the autophagosome-lysosome fusion step and its relation to non-alcoholic fatty liver disease publication-title: Liver Res. doi: 10.1016/j.livres.2018.09.003 – volume: 70 start-page: 538 year: 2020 ident: ref_234 article-title: Multinucleated Giant Cells in Adipose Tissue Are Specialized in Adipocyte Degradation publication-title: Diabetes doi: 10.2337/db20-0293 – volume: 23 start-page: 375 year: 2015 ident: ref_98 article-title: Identification of sex-specific thresholds for accumulation of visceral adipose tissue in adults publication-title: Obesity doi: 10.1002/oby.20961 – ident: ref_26 doi: 10.3390/biom10050761 – ident: ref_183 doi: 10.1371/journal.pone.0019139 – volume: 176 start-page: 19 year: 2018 ident: ref_344 article-title: Caloric restriction and cellular senescence publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2018.10.005 – volume: 5 start-page: e202101286 year: 2022 ident: ref_237 article-title: Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors publication-title: Life Sci. Alliance doi: 10.26508/lsa.202101286 – ident: ref_321 doi: 10.3390/nu15122749 – ident: ref_343 doi: 10.3390/ijms24021703 – volume: 46 start-page: 4271 year: 2018 ident: ref_197 article-title: Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky223 – volume: 58 start-page: 2498 year: 2009 ident: ref_222 article-title: Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance publication-title: Diabetes doi: 10.2337/db09-0216 – ident: ref_298 doi: 10.3390/metabo13121190 – ident: ref_185 doi: 10.3390/ijms22041788 – volume: 16 start-page: 4405 year: 2023 ident: ref_85 article-title: The Role of Adipocyte Endoplasmic Reticulum Stress in Obese Adipose Tissue Dysfunction: A Review publication-title: Int. J. Gen. Med. doi: 10.2147/IJGM.S428482 – volume: 8 start-page: 4677 year: 2018 ident: ref_110 article-title: Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans publication-title: Sci. Rep. doi: 10.1038/s41598-018-22962-x – volume: 17 start-page: 295 year: 2014 ident: ref_57 article-title: The fat cell senescence hypothesis: A mechanism responsible for abrogating the resolution of inflammation in chronic disease publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/MCO.0000000000000077 – volume: 33 start-page: 11541 year: 2019 ident: ref_178 article-title: miR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response publication-title: Faseb J. doi: 10.1096/fj.201900600RR – volume: 174 start-page: 1533 year: 2017 ident: ref_36 article-title: The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13792 – volume: 27 start-page: 264 year: 2019 ident: ref_303 article-title: Bariatric Surgery Alters microRNA Content of Circulating Exosomes in Patients with Obesity publication-title: Obesity doi: 10.1002/oby.22379 – volume: 7 start-page: 505 year: 2018 ident: ref_226 article-title: Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.117.007442 – volume: 7 start-page: 324 year: 2022 ident: ref_289 article-title: The evolving view of thermogenic fat and its implications in cancer and metabolic diseases publication-title: Signal Transduct. Target. Ther. doi: 10.1038/s41392-022-01178-6 – ident: ref_14 doi: 10.3389/fphar.2019.00977 – ident: ref_60 doi: 10.3389/fimmu.2022.831168 – ident: ref_6 doi: 10.3389/fcell.2022.985274 – volume: 15 start-page: 1391 year: 2024 ident: ref_323 article-title: Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape publication-title: Nat. Commun. doi: 10.1038/s41467-024-45724-y – ident: ref_66 doi: 10.3389/fimmu.2022.1068986 – volume: 10 start-page: 95 year: 2019 ident: ref_175 article-title: Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-019-1177-1 – ident: ref_335 doi: 10.1038/s43587-024-00663-7 – volume: 1810 start-page: 148367 year: 2023 ident: ref_239 article-title: Palmitate alters miRNA content of small extracellular vesicles secreted from NPY/AgRP-expressing hypothalamic neurons publication-title: Brain Res. doi: 10.1016/j.brainres.2023.148367 – volume: 38 start-page: 1184 year: 2024 ident: ref_112 article-title: Futile cycles: Emerging utility from apparent futility publication-title: Cell Metab. doi: 10.1016/j.cmet.2024.03.008 – volume: 43 start-page: 1620 year: 2019 ident: ref_282 article-title: Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice publication-title: Int. J. Obes. doi: 10.1038/s41366-018-0212-0 – volume: 19 start-page: 586 year: 2012 ident: ref_129 article-title: The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2296 |
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| Title | Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review |
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