Denigration and sensorimotor disability induced by ventral tegmental injection of 6-hydroxy-dopamine in the cat

• Published in: Experimental neurology Vol. 33; no. 1; pp. 78 - 87
• Main Authors: Frigyesi, Tamas L., Ige, Anthony, Iulo, Aldo, Schwartz, Robert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.1971
• Subjects: Animals; Behavior, Animal; Cats; Disease Models, Animal; Dopamine - pharmacology; Female; Mesencephalon - drug effects; Movement Disorders - chemically induced; Neurons - drug effects; Parkinson Disease; Substantia Nigra - physiology; Tegmentum Mesencephali - drug effects; Tegmentum Mesencephali - physiology

Selective total destruction of the feline substantia nigra (SN) is virtually impossible. Fulgurative lesions producing partial nigral destruction, with or without encroachment on neighboring structures, have been ineffective in producing lasting abnormalities of the sensorimotor activities of the ca...