CYP24A1 affected macrophage polarization through degradation of vitamin D as a candidate biomarker for ovarian cancer prognosis

• Published in: International immunopharmacology Vol. 138; p. 112575
• Main Authors: Lin, YaoXiang, Chen, JiongFei, Xin, SiJia, Lin, Ya, Chen, YongChao, Zhou, Xiaojing, Chen, Hao, Li, XiangJuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.09.2024
• Subjects: Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell Line, Tumor; CYP24A1; Female; Gene Expression Regulation, Neoplastic; Humans; Macrophage; Macrophage Activation; Macrophages - immunology; Macrophages - metabolism; Mice; Mitochondria; Ovarian cancer; Ovarian Neoplasms - immunology; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Prognosis; Vitamin D; Vitamin D - metabolism; Vitamin D - pharmacology; Vitamin D3 24-Hydroxylase - genetics; Vitamin D3 24-Hydroxylase - metabolism; Mitochondria; CYP24A1; Vitamin D; Ovarian cancer; Macrophage

[Display omitted] •CYP24A1 regulated macrophage polarization through vitamin D (VD) degradation and served as a target gene for the second malignant subtype of OC through bioinformatics analyses.•The expression of CYP24A1 was much higher in carcinoma than in paracancerous tissue, whereas the VD cont...