Sputum from chronic obstructive pulmonary disease patients inhibits T cell migration in a microfluidic device

• Published in: Annals of the New York Academy of Sciences Vol. 1445; no. 1; pp. 52 - 61
• Main Authors: Ren, Xiaoou, Wu, Jiandong, Levin, David, Santos, Susy, Faria, Ricardo Lobato, Zhang, Michael, Lin, Francis
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2019
• Subjects: Cell adhesion & migration; Cell Migration Inhibition - physiology; Cell Movement - physiology; Chemokine CXCL12 - metabolism; Chemotaxis; Chronic obstructive pulmonary disease; Humans; Infiltration; Inflammation; Leukocyte migration; Leukocytes; Lung diseases; Lymphocytes; Lymphocytes T; microfluidic device; Microfluidic devices; Microfluidics; migration; Obstructive lung disease; Pathogenesis; Peripheral blood; Pulmonary Disease, Chronic Obstructive - pathology; Respiratory tract; Sputum; Sputum - metabolism; T cell; T-Lymphocytes - metabolism; migration; sputum; microfluidic device; T cell; chemotaxis; chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by narrowed airways, resulting in serious breathing difficulty. Previous studies have demonstrated that inflammatory infiltration of leukocytes in the airway is associated with the pathogenesis of COPD. In the presen...