Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons

• Published in: Glia Vol. 67; no. 4; pp. 634 - 649
• Main Authors: Lüders, Katja A., Nessler, Stefan, Kusch, Kathrin, Patzig, Julia, Jung, Ramona B., Möbius, Wiebke, Nave, Klaus‐Armin, Werner, Hauke B.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2019; Wiley Subscription Services, Inc
• Subjects: Animal models; Axon guidance; Axons; Biosynthesis; Brain; Central nervous system; Chronology; Cytotoxicity; Gene expression; Genetic disorders; glia‐axonal support; Gliosis; Infiltration; Integrity; Lamellae; Membrane proteins; Membranes; Myelin; Myelin proteolipid protein; myelin turnover; Myelination; Nervous system; neuropathology; oligodendrocyte; Oligodendrocytes; Preservation; Proteins; proteolipid protein (PLP); spastic paraplegia; Spasticity; Spheroids; Substantia alba; Tamoxifen; myelin turnover; spastic paraplegia; proteolipid protein (PLP); glia-axonal support; oligodendrocyte; neuropathology; tamoxifen

Proteolipid protein (PLP) is the most abundant integral membrane protein in central nervous system (CNS) myelin. Expression of the Plp‐gene in oligodendrocytes is not essential for the biosynthesis of myelin membranes but required to prevent axonal pathology. This raises the question whether the exc...