Influences of CD8 + Tregs on Peripheral Blood Mononuclear Cells from Allergic Rhinitis Patients

• Published in: The Laryngoscope Vol. 131; no. 2; p. E316
• Main Authors: Lin, Lin, Dai, Fei, Wei, Jinjin, Chen, Zheng
• Format: Journal Article
• Language: English
• Published: United States 01.02.2021
• Subjects: Adult; Case-Control Studies; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cells, Cultured; Female; Healthy Volunteers; Humans; Interleukin-10 - metabolism; Interleukin-4 - metabolism; Interleukin-5 - metabolism; Male; Middle Aged; Primary Cell Culture; Rhinitis, Allergic - blood; Rhinitis, Allergic - immunology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Transforming Growth Factor beta - metabolism; CD8+ tregs; CD4+ tregs; allergic rhinitis; PBMCs

CD8 (or CD4 ) CD25 fork-head box transcription factor (Foxp3) regulatory T cells (CD8 or CD4 Tregs) all play a significant role in immune homeostasis and tolerance. However, the role of CD8 Tregs in allergic rhinitis (AR) have not been clearly elucidated. The present study was aimed to assess the in...