Novel Bilayer Microarray Patch‐Assisted Long‐Acting Micro‐Depot Cabotegravir Intradermal Delivery for HIV Pre‐Exposure Prophylaxis

• Published in: Advanced functional materials Vol. 32; no. 9
• Main Authors: Tekko, Ismaiel A., Vora, Lalitkumar K., Volpe‐Zanutto, Fabiana, Moffatt, Kurtis, Jarrahian, Courtney, McCarthy, Helen O., Donnelly, Ryan F.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.02.2022
• Subjects: Antiretroviral drugs; cabotegravir; Disease prevention; dissolving microarray patch; HIV; Human immunodeficiency virus; In vivo methods and tests; long‐acting drugs; Materials science; Mechanical properties; pre‐exposure prophylaxis; Prophylaxis; Sodium salts; Tips

Injectable long‐acting cabotegravir (CAB LA) is effective and safe for pre‐exposure HIV prophylaxis. It is recently approved for clinical use in those at high risk of contracting HIV. However, injections are invasive and access to trained healthcare personnel to administer CAB LA can be limited, esp...