Longitudinal changes of swallowing safety and efficiency in infants with spinal muscular atrophy who received disease modifying therapies

• Published in: Pediatric pulmonology Vol. 59; no. 5; pp. 1364 - 1371
• Main Authors: Leon‐Astudillo, Carmen, Brooks, Olivia, Salabarria, Stephanie M., Coker, Mackenzi, Corti, Manuela, Lammers, Jenna, Plowman, Emily K., Byrne, Barry J., Smith, Barbara K.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2024
• Subjects: Child, Preschool; Deglutition - physiology; Deglutition Disorders - etiology; Deglutition Disorders - physiopathology; dysphagia; Efficiency; Female; Fluoroscopy; gene therapy; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Medical screening; Muscular Atrophy, Spinal - drug therapy; Muscular Atrophy, Spinal - physiopathology; nusinersen; risdiplam; spinal muscular atrophy; dysphagia; gene therapy; nusinersen; spinal muscular atrophy; risdiplam

Background Dysphagia is a common feature of the natural history of patients with spinal muscular atrophy (SMA). Literature regarding swallowing safety and efficiency is scarce in patients with SMA, particularly in the era of newborn screening programs and disease‐modifying therapies. Objective To de...