Characterizing the T Cell Repertoire in the Proximal Airway in Health and Disease

• Published in: The Laryngoscope Vol. 134; no. 4; p. 1757
• Main Authors: Clark, Evan A, Talatala, Edward Ryan R, Ye, Wenda, Davis, Ruth J, Collins, Samuel L, Hillel, Alexander T, Ramirez-Solano, Marisol, Sheng, Quanhu, Wanjalla, Celestine N, Mallal, Simon A, Gelbard, Alexander
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: TCR; subglottis; idiopathic subglottic stenosis: iSGS; adaptive immunity; T cell repertoire

Recent translational scientific efforts in subglottic stenosis (SGS) support a disease model where epithelial alterations facilitate microbiome displacement, dysregulated immune activation, and localized fibrosis. Given the observed immune cell infiltrate in SGS, we sought to test the hypothesis tha...