The β3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test

• Published in: Pain (Amsterdam) Vol. 144; no. 3; pp. 294 - 302
• Main Authors: LACROIX-FRALISH, Michael L, MO, Gary, ROMANOVSKY, Dmitry, GUOCHUN LIAO, BEHLKE, Mark A, CLARK, David J, PELTZ, Gary, SEGUELA, Philippe, DOBRETSOV, Maxim, MOGIL, Jeffrey S, SMITH, Shad B, SOTOCINAL, Susana G, RITCHIE, Jennifer, AUSTIN, Jean-Sebastien, MELMED, Kara, SCHORSCHER-PETCU, Ara, LAFERRIERE, Audrey C, TAE HOON LEE
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier 01.08.2009
• Subjects: Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Medical sciences; Other diseases. Semiology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Vertebrates: nervous system and sense organs; Spinal cord; Variability; Central nervous system; K; Subunit; Pain; Na; Coding; Genetics; Sodium-potassium pump; Behavior; Quantitative analysis; Pain sensitivity; Nociception; Enzyme; Early phase; Genetic variant; Rodentia; Formalin; Protein; Strain; Vertebrata; Mammalia; Mouse; Hydrolases; exchanging ATPase; Gene mapping

It is widely appreciated that there is significant inter-individual variability in pain sensitivity, yet only a handful of contributing genetic variants have been identified. Computational genetic mapping and quantitative trait locus analysis suggested that variation within the gene coding for the β...