Conversion from tacrolimus to sirolimus as a treatment modality in de novo allergies and immune‐mediated disorders in pediatric liver transplant recipients

• Published in: Pediatric transplantation Vol. 24; no. 6; pp. e13737 - n/a
• Main Authors: Kehar, Mohit, Grunebaum, Eyal, Jimenez‐Rivera, Carolina, Mozer‐Glassberg, Yael, Jamal, Alisha, Ng, Vicky Lee, Avitzur, Yaron
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.09.2020
• Subjects: Calcineurin; Calcineurin inhibitors; Colitis; Eczema; eosinophilic colitis; eosinophilic gastroenteritis; Food allergies; food allergy; Graft rejection; immune dysregulation; Immunosuppression; Leukocytes (eosinophilic); Liver diseases; Liver transplantation; Liver transplants; Patients; Pediatrics; Rapamycin; Tacrolimus; TOR protein; Transplants & implants; eczema; food allergy; tacrolimus; eosinophilic gastroenteritis; eosinophilic colitis; immune dysregulation

De novo PTAID may develop in pediatric solid organ transplant recipients, have a diverse spectrum, and are occasionally treatment resistant. Previous reports showed resolution of immune cytopenias in solid organ transplant recipients following replacement of the calcineurin inhibitor tacrolimus with...