Intravoxel Incoherent Motion Magnetic Resonance Imaging for Prediction of Induction Chemotherapy Response in Locally Advanced Hypopharyngeal Carcinoma: Comparison With Model‐Free Dynamic Contrast‐Enhanced Magnetic Resonance Imaging

• Published in: Journal of magnetic resonance imaging Vol. 54; no. 1; pp. 91 - 100
• Main Authors: Guo, Baoliang, Ouyang, Fusheng, Ouyang, Lizhu, Huang, Xiyi, Guo, Tiandi, Lin, Shaojia, Liu, Ziwei, Zhang, Rong, Yang, Shao‐min, Chen, Haixiong, Hu, Qiu‐gen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2021; Wiley Subscription Services, Inc
• Subjects: Cancer; Chemotherapy; Confidence intervals; Diffusion coefficient; dynamic contrast‐enhanced MR imaging; Field strength; hypopharyngeal carcinoma; induction chemotherapy; intra‐voxel incoherent motion; Magnetic induction; Magnetic resonance imaging; Mathematical models; Medical imaging; Parameters; Perfusion; Population studies; Resonance; Solid tumors; Statistical analysis; Statistical tests; Throat cancer; treatment response; Tumors; dynamic contrast-enhanced MR imaging; hypopharyngeal carcinoma; induction chemotherapy; treatment response; intra-voxel incoherent motion
• DOI: 10.1002/jmri.27537
• ISSN: 1053-1807

Background Multiparametric intravoxel incoherent motion (IVIM) provides diffusion and perfusion information for the treatment prediction of cancer. However, the superiority of IVIM over dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) in locally advanced hypopharyngeal carcinoma (LAHC) remains unclear. Purpose To compare the diagnostic performance of IVIM and model‐free DCE in assessing induction chemotherapy (IC) response in patients with LAHC. Study Type Prospective. Population Forty‐two patients with LAHC. Field Strength/Sequence 3.0 T MRI, including IVIM (12 b values, 0–800 seconds/mm2) with a single‐shot echo planar imaging sequence and DCE‐MRI with a volumetric interpolated breath‐hold examination sequence. IVIM MRI is a commercially available sequence and software for calculation and analysis from vendor. Assessment The IVIM‐derived parameters (diffusion coefficient [D], pseudodiffusion coefficient [D*], and perfusion fraction [f]) and DCE‐derived model‐free parameters (Wash‐in, time to maximum enhancement [Tmax], maximum enhancement [Emax], area under enhancement curve [AUC] over 60 seconds [AUC60], and whole area under enhancement curve [AUCw]) were measured. At the end of IC, patients with complete or partial response were classified as responders according to the Response Evaluation Criteria in Solid Tumors. Statistical Tests The differences of parameters between responders and nonresponders were assessed using Mann–Whitney U tests. The performance of parameters for predicting IC response was evaluated by the receiver operating characteristic curves. Results Twenty‐three (54.8%) patients were classified as responders. Compared with nonresponders, the perfusion parameters D*, f, f × D*, and AUCw were significantly higher whereas Wash‐in was lower in responders (all P‐values <0.05). The f × D* outperformed other parameters, with an AUC of 0.84 (95% confidence interval [CI]: 0.69–0.93), sensitivity of 79.0% (95% CI: 54.4–93.9), and specificity of 82.6% (95% CI: 61.2–95.0). Data Conclusion The IVIM MRI technique may noninvasively help predict the IC response before treatment in patients with LAHC. Level of Evidence 2 Technical Efficacy Stage 2