Identification of T cell epitopes on soluble liver antigen in Chinese patients with auto-immune hepatitis

• Published in: Liver international Vol. 31; no. 5; pp. 721 - 729
• Main Authors: Zhao, Yan, Zhang, Yonghong, Liu, Yan-min, Liu, Yan, Feng, Xia, Liao, Hui-yu, Vergani, Diego, Ma, Yun, Yan, Hui-ping
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2011
• Subjects: Adult; Aged; Asian Continental Ancestry Group; Aspartate Aminotransferases - blood; auto-immunity; Autoantibodies - blood; autoantibody; Autoantigens - immunology; Biomarkers - blood; Case-Control Studies; CD4-Positive T-Lymphocytes - immunology; Cells, Cultured; Chi-Square Distribution; China; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; epitopes; Epitopes, T-Lymphocyte; Female; hepatitis; Hepatitis, Autoimmune - enzymology; Hepatitis, Autoimmune - ethnology; Hepatitis, Autoimmune - immunology; HLA-DR Antigens - immunology; HLA-DRB1 Chains; Humans; Immunodominant Epitopes; Interferon-gamma - metabolism; Male; Middle Aged; Severity of Illness Index; T cells; China

Aim: To identify soluble liver antigen (SLA)‐specific dominant epitopes and analyse the correlation between SLA‐specific T cell response and the status of the disease. Methods: A cross‐sectional analysis of SLA‐specific T cell responses to 54 overlapping peptides covering the entire SLA sequence was...