HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal

• Published in: The Journal of clinical investigation Vol. 133; no. 11
• Main Authors: Pierce, Carl A, Loh, Lip Nam, Steach, Holly R, Cheshenko, Natalia, Preston-Hurlburt, Paula, Zhang, Fengrui, Stransky, Stephanie, Kravets, Leah, Sidoli, Simone, Philbrick, William, Nassar, Michel, Krishnaswamy, Smita, Herold, Kevan C, Herold, Betsy C
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.06.2023
• Subjects: AIDS/HIV; CD4-Positive T-Lymphocytes; Etoposide; Herpesvirus 2, Human - genetics; HIV Infections - genetics; Humans; RNA, Long Noncoding - genetics; Up-Regulation; Virology; Virus Latency; AIDS/HIV; Transcription; T cells; Virology

Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined. HSV-2 recurrences result in an influx of activated CD4+ T cells to sites of viral replication and an increase in activated CD4+ T ce...