Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms

• Published in: The Journal of pathology Vol. 205; no. 4; pp. 507 - 513
• Main Authors: Carreras, Joaquim, Villamor, Neus, Colomo, Lluís, Moreno, Carol, Cajal, Santiago Ramón y, Crespo, Marta, Tort, Frederic, Bosch, Francesc, López-Guillermo, Armando, Colomer, Dolors, Montserrat, Emili, Campo, Elías
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2005; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; B-cell lymphoproliferative disorders; Biological and medical sciences; Female; Flow Cytometry - methods; Genes, Immunoglobulin - genetics; Hematologic and hematopoietic diseases; Hodgkin Disease - genetics; Hodgkin Disease - metabolism; Humans; immunohistochemistry; Immunohistochemistry - methods; Investigative techniques, diagnostic techniques (general aspects); Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, B-Cell - chemistry; Lymphoma, B-Cell - genetics; Lymphoma, Mantle-Cell - genetics; Lymphoma, Mantle-Cell - metabolism; Male; Medical sciences; Middle Aged; Mutation; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prognosis; Protein-Tyrosine Kinases - analysis; ZAP-70; ZAP-70 Protein-Tyrosine Kinase; Immunohistochemistry; ZAP-70; Anatomic pathology; Lymphoid cell; Lymphoproliferative syndrome; Malignant hemopathy; B-Lymphocyte; β Cell; B-cell lymphoproliferative disorders

ZAP‐70 is a tyrosine kinase that participates in early B‐cell differentiation and is a prognostic factor in chronic lymphocytic leukaemia (CLL), where it is associated with an unmutated configuration of the IgVH genes. In this study ZAP‐70 expression was studied by immunohistochemistry in a spectrum...