Biophysical evidence to support and extend the vitamin D‐folate hypothesis as a paradigm for the evolution of human skin pigmentation

• Published in: American journal of human biology Vol. 34; no. 4; pp. e23667 - n/a
• Main Authors: Lucock, Mark D., Jones, Patrice R., Veysey, Martin, Thota, Rohith, Garg, Manohar, Furst, John, Martin, Charlotte, Yates, Zoe, Scarlett, Christopher J., Jablonski, Nina G., Chaplin, George, Beckett, Emma L.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2022; Wiley Subscription Services, Inc
• Subjects: Antioxidants; Australia; Blood; Calciferol; Carotene; Cross-Sectional Studies; Evolution; Folic Acid; Gene mapping; Gene polymorphism; Genes; Genetic analysis; Genotype; Genotype & phenotype; High-performance liquid chromatography; Humans; Hypotheses; Immunoassay; Interferon regulatory factor 4; Irradiance; Light levels; Liquid chromatography; Methylenetetrahydrofolate reductase; Photosynthesis; Pigmentation; Population genetics; Population studies; Riboflavin; Skin pigmentation; Skin Pigmentation - genetics; Skin tests; Total Ozone Mapping Spectrometer; Ultraviolet radiation; Ultraviolet Rays - adverse effects; Vitamin B; Vitamin D; Vitamin D receptors; Vitamin D3; Vitamins; β-Carotene; Australia

Objective To test the “vitamin D‐folate hypothesis for the evolution of human skin pigmentation.” Methods Total ozone mapping spectrometer (TOMS) satellite data were used to examine surface UV‐irradiance in a large (n = 649) Australian cross‐sectional study population. Genetic analysis was used to s...