Enhanced innate responses in microglia derived from retinoblastoma patient‐specific iPSCs

• Published in: Glia Vol. 72; no. 5; pp. 872 - 884
• Main Authors: Xu, Jia, Yu, Si‐Jian, Sun, Shuning, Li, Yan‐Ping, Zhang, Xiao, Jin, Kangxin, Jin, Zi‐Bing
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2024; Wiley Subscription Services, Inc
• Subjects: cytokine; Embryo cells; Enzyme-linked immunosorbent assay; Homeostasis; Humans; Immune response; Immune system; Immunofluorescence; Induced Pluripotent Stem Cells - metabolism; Innate immunity; Macrophages; Malignancy; MAP kinase; Microglia; Microglia - metabolism; mRNA; Organoids; Phagocytes; Phagocytosis; Pluripotency; RB1; Retina; Retinal Neoplasms - genetics; Retinal Neoplasms - metabolism; Retinal Neoplasms - pathology; Retinoblastoma; Retinoblastoma - genetics; Retinoblastoma - metabolism; Retinoblastoma - pathology; Signal transduction; Stem cells; RB1; cytokine; innate immunity; retinoblastoma; microglia

RB1 deficiency leads to retinoblastoma (Rb), the most prevalent intraocular malignancy. Tumor‐associated macrophages (TAMs) are related to local inflammation disorder, particularly by increasing cytokines and immune escape. Microglia, the unique resident macrophages for retinal homeostasis, are the...