Childhood asthma and cardiovascular morbidity and mortality in adulthood: The Busselton Health Study

Background Long‐term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations of childhood asthma and the occurrence of cardiovascular disease (CVD) events and mortality in adulthood. Methods A cohort of 4430 school c...

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Published inPediatric pulmonology Vol. 56; no. 7; pp. 1915 - 1923
Main Authors Ng, Christopher A. C. M., Knuiman, Matthew W., Murray, Kevin, Divitini, Mark L., Musk, Arthur W. (Bill), James, Alan L.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.07.2021
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Abstract Background Long‐term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations of childhood asthma and the occurrence of cardiovascular disease (CVD) events and mortality in adulthood. Methods A cohort of 4430 school children (aged 17 years) who attended the Busselton Health Study between 1967 and 1983 were analyzed. Self‐reported history of doctor‐diagnosed asthma was determined based on the questionnaire. Subsequent CVD events (hospital admissions or death) up to 2014 were identified using the Western Australia Data Linkage System. Cox regression models were used to investigate the impact of childhood asthma on CVD events and mortality in adulthood. A subgroup of 2153 participants who re‐attended a survey in young adulthood was also analyzed. Results A total of 462 (10%) of the cohort had childhood asthma. During follow‐up, 867 participants experienced a CVD event and 22 participants died from CVD. Childhood asthma was not associated with the risk of CVD events in adulthood (HR, 1.12; 95% CI: 0.91–1.39; p = .2833) and this persisted after adjustment for confounders. Childhood asthma was not associated with coronary heart disease events (HR, 0.72; 95% CI: 0.40–1.30; p = .2761), heart failure events (HR, 0.55; 95% CI: 0.07–4.13; p = .5604) or CVD mortality (HR, 0.91; 95% CI: 0.21–3.89; p = .8987) in adulthood. Conclusion Childhood asthma is not associated with the risk of CVD events and mortality in adulthood.
AbstractList Long-term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations of childhood asthma and the occurrence of cardiovascular disease (CVD) events and mortality in adulthood. A cohort of 4430 school children (aged 17 years) who attended the Busselton Health Study between 1967 and 1983 were analyzed. Self-reported history of doctor-diagnosed asthma was determined based on the questionnaire. Subsequent CVD events (hospital admissions or death) up to 2014 were identified using the Western Australia Data Linkage System. Cox regression models were used to investigate the impact of childhood asthma on CVD events and mortality in adulthood. A subgroup of 2153 participants who re-attended a survey in young adulthood was also analyzed. A total of 462 (10%) of the cohort had childhood asthma. During follow-up, 867 participants experienced a CVD event and 22 participants died from CVD. Childhood asthma was not associated with the risk of CVD events in adulthood (HR, 1.12; 95% CI: 0.91-1.39; p = .2833) and this persisted after adjustment for confounders. Childhood asthma was not associated with coronary heart disease events (HR, 0.72; 95% CI: 0.40-1.30; p = .2761), heart failure events (HR, 0.55; 95% CI: 0.07-4.13; p = .5604) or CVD mortality (HR, 0.91; 95% CI: 0.21-3.89; p = .8987) in adulthood. Childhood asthma is not associated with the risk of CVD events and mortality in adulthood.
BACKGROUNDLong-term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations of childhood asthma and the occurrence of cardiovascular disease (CVD) events and mortality in adulthood. METHODSA cohort of 4430 school children (aged 17 years) who attended the Busselton Health Study between 1967 and 1983 were analyzed. Self-reported history of doctor-diagnosed asthma was determined based on the questionnaire. Subsequent CVD events (hospital admissions or death) up to 2014 were identified using the Western Australia Data Linkage System. Cox regression models were used to investigate the impact of childhood asthma on CVD events and mortality in adulthood. A subgroup of 2153 participants who re-attended a survey in young adulthood was also analyzed. RESULTSA total of 462 (10%) of the cohort had childhood asthma. During follow-up, 867 participants experienced a CVD event and 22 participants died from CVD. Childhood asthma was not associated with the risk of CVD events in adulthood (HR, 1.12; 95% CI: 0.91-1.39; p = .2833) and this persisted after adjustment for confounders. Childhood asthma was not associated with coronary heart disease events (HR, 0.72; 95% CI: 0.40-1.30; p = .2761), heart failure events (HR, 0.55; 95% CI: 0.07-4.13; p = .5604) or CVD mortality (HR, 0.91; 95% CI: 0.21-3.89; p = .8987) in adulthood. CONCLUSIONChildhood asthma is not associated with the risk of CVD events and mortality in adulthood.
Background Long‐term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations of childhood asthma and the occurrence of cardiovascular disease (CVD) events and mortality in adulthood. Methods A cohort of 4430 school children (aged 17 years) who attended the Busselton Health Study between 1967 and 1983 were analyzed. Self‐reported history of doctor‐diagnosed asthma was determined based on the questionnaire. Subsequent CVD events (hospital admissions or death) up to 2014 were identified using the Western Australia Data Linkage System. Cox regression models were used to investigate the impact of childhood asthma on CVD events and mortality in adulthood. A subgroup of 2153 participants who re‐attended a survey in young adulthood was also analyzed. Results A total of 462 (10%) of the cohort had childhood asthma. During follow‐up, 867 participants experienced a CVD event and 22 participants died from CVD. Childhood asthma was not associated with the risk of CVD events in adulthood (HR, 1.12; 95% CI: 0.91–1.39; p = .2833) and this persisted after adjustment for confounders. Childhood asthma was not associated with coronary heart disease events (HR, 0.72; 95% CI: 0.40–1.30; p = .2761), heart failure events (HR, 0.55; 95% CI: 0.07–4.13; p = .5604) or CVD mortality (HR, 0.91; 95% CI: 0.21–3.89; p = .8987) in adulthood. Conclusion Childhood asthma is not associated with the risk of CVD events and mortality in adulthood.
Author Murray, Kevin
James, Alan L.
Divitini, Mark L.
Ng, Christopher A. C. M.
Musk, Arthur W. (Bill)
Knuiman, Matthew W.
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Snippet Background Long‐term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the...
Long-term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations of...
BackgroundLong‐term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations...
BACKGROUNDLong-term childhood asthma studies that investigate adult outcomes other than respiratory morbidity are lacking. This study examines the associations...
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StartPage 1915
SubjectTerms Asthma
Cardiovascular disease
cardiovascular diseases
Childhood
Childrens health
Cohort analysis
cohort study
morbidity
Mortality
Title Childhood asthma and cardiovascular morbidity and mortality in adulthood: The Busselton Health Study
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fppul.25386
https://www.ncbi.nlm.nih.gov/pubmed/33819390
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Volume 56
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