Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

• Published in: American journal of industrial medicine Vol. 63; no. 1; pp. 74 - 84
• Main Authors: Salum, Kaio Cezar Rodrigues, Castro, Marcos Cesar Santos, Moreira, Valéria Barbosa, Nani, Angela Santos Ferreira, Kohlrausch, Fabiana Barzotto
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2020
• Subjects: Alleles; association study; Brazil; Confidence intervals; Crystal structure; Crystallinity; Cytokines; Exposure; Female; Fibrosis; Gene polymorphism; Genetic Predisposition to Disease; Genetic Variation; genetics; Genotype; Humans; Inflammation; Inhalation; Interleukin 1; Interleukin-1alpha - genetics; Interleukin-1beta - genetics; Interleukins; Lung diseases; Male; Nucleotides; Occupational Exposure; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Respiration; Restriction fragment length polymorphism; Risk Factors; Silica; Silicon dioxide; Silicon Dioxide - toxicity; Silicosis; Silicosis - genetics; Single-nucleotide polymorphism; Tuberculosis; Tuberculosis - genetics; Tumor Necrosis Factor-alpha - genetics; Brazil; silicosis; cytokines; polymorphism; genetics; association study; tuberculosis

Introduction Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the dev...