Reliability of neurometabolite detection with two‐dimensional localized correlation spectroscopy at 3T

• Published in: Journal of magnetic resonance imaging Vol. 48; no. 6; pp. 1559 - 1569
• Main Authors: Arm, Jameen, Al‐iedani, Oun, Quadrelli, Scott, Ribbons, Karen, Lea, Rod, Lechner‐Scott, Jeannette, Ramadan, Saadallah
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: Brain; Coefficient of variation; Correlation analysis; Correlation coefficient; Correlation coefficients; Cortex (cingulate); Data processing; Error analysis; Field strength; High definition; In vivo methods and tests; localized correlation spectroscopy; L‐COSY; Magnetic resonance imaging; Magnetic resonance spectroscopy; Mathematical analysis; Metabolites; MRI; MRS; Neuroimaging; Population (statistical); Population studies; Reliability analysis; repeatability; Reproducibility; Spectroscopy; Spectrum analysis; Standard error; Statistical analysis; Statistical tests; Variability; repeatability; magnetic resonance imaging; MRI; L-COSY; magnetic resonance spectroscopy; localized correlation spectroscopy; MRS

BACKGROUND Two‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detecti...