Reliability of neurometabolite detection with two‐dimensional localized correlation spectroscopy at 3T
BACKGROUND Two‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detecti...
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| Published in | Journal of magnetic resonance imaging Vol. 48; no. 6; pp. 1559 - 1569 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.12.2018
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| Online Access | Get full text |
| ISSN | 1053-1807 1522-2586 1522-2586 |
| DOI | 10.1002/jmri.26036 |
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| Abstract | BACKGROUND
Two‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test–retest measurements.
PURPOSE
To evaluate the test–retest repeatability/reliability of 2D L‐COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner.
STUDY TYPE
Test–retest. POPULATION/PHANTOM: Six healthy subjects and magnetic resonance spectroscopy–high definition (MRS‐HD) sphere or “Braino”.
FIELD STRENGTH/SEQUENCE
3T/2D L‐COSY MRS.
ASSESSMENT
Healthy subjects underwent eight weekly experiments over a period of 3 months with an intersession delay of 1 month after the first four measurements. Twenty‐nine neurometabolite resonances (8 diagonal, 14 cross, and 7 composite resonances) were studied using a 27 cm3 voxel from the posterior cingulate cortex. In vitro evaluations were performed in a similar manner as in vivo on a Braino phantom containing brain metabolites at physiological concentrations and pH.
STATISTICAL TESTS
Intra‐ and intersubject variability were measured. Test–retest repeatability was calculated using coefficient of variation (CV), and reliability was assessed with standard error measurement (SEM) and intraclass correlation coefficient (ICC), using SPSS software.
RESULTS
The intra/inter CV for in vitro and in vivo data ranged from 0.01–0.23%/0.02–0.29% and 0.03–0.23%/0.04–0.39%, respectively. The major diagonal peaks showed ICC ranging from 0.31 to 0.93, while the ICC for cross peaks were 0.09–0.87. The SEM for in vivo data ranged from 0.0016 to 0.08. The interweek interval may have a positive effect on metabolite ratios (P = 0.08; F = 1.78).
DATA CONCLUSION
The low variability in metabolite concentration in this study shows a high level of reliability of 2D L‐COSY in the human brain.
Level of Evidence: 2
Technical Efficacy: Stage 1
J. Magn. Reson. Imaging 2018;48:1559–1569 |
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| AbstractList | BACKGROUNDTwo‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test–retest measurements.PURPOSETo evaluate the test–retest repeatability/reliability of 2D L‐COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner.STUDY TYPETest–retest. POPULATION/PHANTOM: Six healthy subjects and magnetic resonance spectroscopy–high definition (MRS‐HD) sphere or “Braino”.FIELD STRENGTH/SEQUENCE3T/2D L‐COSY MRS.ASSESSMENTHealthy subjects underwent eight weekly experiments over a period of 3 months with an intersession delay of 1 month after the first four measurements. Twenty‐nine neurometabolite resonances (8 diagonal, 14 cross, and 7 composite resonances) were studied using a 27 cm3 voxel from the posterior cingulate cortex. In vitro evaluations were performed in a similar manner as in vivo on a Braino phantom containing brain metabolites at physiological concentrations and pH.STATISTICAL TESTSIntra‐ and intersubject variability were measured. Test–retest repeatability was calculated using coefficient of variation (CV), and reliability was assessed with standard error measurement (SEM) and intraclass correlation coefficient (ICC), using SPSS software.RESULTSThe intra/inter CV for in vitro and in vivo data ranged from 0.01–0.23%/0.02–0.29% and 0.03–0.23%/0.04–0.39%, respectively. The major diagonal peaks showed ICC ranging from 0.31 to 0.93, while the ICC for cross peaks were 0.09–0.87. The SEM for in vivo data ranged from 0.0016 to 0.08. The interweek interval may have a positive effect on metabolite ratios (P = 0.08; F = 1.78).DATA CONCLUSIONThe low variability in metabolite concentration in this study shows a high level of reliability of 2D L‐COSY in the human brain.Level of Evidence: 2Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2018;48:1559–1569 BACKGROUND Two‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test–retest measurements. PURPOSE To evaluate the test–retest repeatability/reliability of 2D L‐COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner. STUDY TYPE Test–retest. POPULATION/PHANTOM: Six healthy subjects and magnetic resonance spectroscopy–high definition (MRS‐HD) sphere or “Braino”. FIELD STRENGTH/SEQUENCE 3T/2D L‐COSY MRS. ASSESSMENT Healthy subjects underwent eight weekly experiments over a period of 3 months with an intersession delay of 1 month after the first four measurements. Twenty‐nine neurometabolite resonances (8 diagonal, 14 cross, and 7 composite resonances) were studied using a 27 cm3 voxel from the posterior cingulate cortex. In vitro evaluations were performed in a similar manner as in vivo on a Braino phantom containing brain metabolites at physiological concentrations and pH. STATISTICAL TESTS Intra‐ and intersubject variability were measured. Test–retest repeatability was calculated using coefficient of variation (CV), and reliability was assessed with standard error measurement (SEM) and intraclass correlation coefficient (ICC), using SPSS software. RESULTS The intra/inter CV for in vitro and in vivo data ranged from 0.01–0.23%/0.02–0.29% and 0.03–0.23%/0.04–0.39%, respectively. The major diagonal peaks showed ICC ranging from 0.31 to 0.93, while the ICC for cross peaks were 0.09–0.87. The SEM for in vivo data ranged from 0.0016 to 0.08. The interweek interval may have a positive effect on metabolite ratios (P = 0.08; F = 1.78). DATA CONCLUSION The low variability in metabolite concentration in this study shows a high level of reliability of 2D L‐COSY in the human brain. Level of Evidence: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:1559–1569 Two-dimensional localized correlational spectroscopy (2D L-COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test-retest measurements. To evaluate the test-retest repeatability/reliability of 2D L-COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner. Test-retest. Six healthy subjects and magnetic resonance spectroscopy-high definition (MRS-HD) sphere or "Braino". 3T/2D L-COSY MRS. Healthy subjects underwent eight weekly experiments over a period of 3 months with an intersession delay of 1 month after the first four measurements. Twenty-nine neurometabolite resonances (8 diagonal, 14 cross, and 7 composite resonances) were studied using a 27 cm voxel from the posterior cingulate cortex. In vitro evaluations were performed in a similar manner as in vivo on a Braino phantom containing brain metabolites at physiological concentrations and pH. Intra- and intersubject variability were measured. Test-retest repeatability was calculated using coefficient of variation (CV), and reliability was assessed with standard error measurement (SEM) and intraclass correlation coefficient (ICC), using SPSS software. The intra/inter CV for in vitro and in vivo data ranged from 0.01-0.23%/0.02-0.29% and 0.03-0.23%/0.04-0.39%, respectively. The major diagonal peaks showed ICC ranging from 0.31 to 0.93, while the ICC for cross peaks were 0.09-0.87. The SEM for in vivo data ranged from 0.0016 to 0.08. The interweek interval may have a positive effect on metabolite ratios (P = 0.08; F = 1.78). The low variability in metabolite concentration in this study shows a high level of reliability of 2D L-COSY in the human brain. 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:1559-1569. Two-dimensional localized correlational spectroscopy (2D L-COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test-retest measurements.BACKGROUNDTwo-dimensional localized correlational spectroscopy (2D L-COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test-retest measurements.To evaluate the test-retest repeatability/reliability of 2D L-COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner.PURPOSETo evaluate the test-retest repeatability/reliability of 2D L-COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner.Test-retest.STUDY TYPETest-retest.Six healthy subjects and magnetic resonance spectroscopy-high definition (MRS-HD) sphere or "Braino".POPULATION/PHANTOMSix healthy subjects and magnetic resonance spectroscopy-high definition (MRS-HD) sphere or "Braino".3T/2D L-COSY MRS.FIELD STRENGTH/SEQUENCE3T/2D L-COSY MRS.Healthy subjects underwent eight weekly experiments over a period of 3 months with an intersession delay of 1 month after the first four measurements. Twenty-nine neurometabolite resonances (8 diagonal, 14 cross, and 7 composite resonances) were studied using a 27 cm3 voxel from the posterior cingulate cortex. In vitro evaluations were performed in a similar manner as in vivo on a Braino phantom containing brain metabolites at physiological concentrations and pH.ASSESSMENTHealthy subjects underwent eight weekly experiments over a period of 3 months with an intersession delay of 1 month after the first four measurements. Twenty-nine neurometabolite resonances (8 diagonal, 14 cross, and 7 composite resonances) were studied using a 27 cm3 voxel from the posterior cingulate cortex. In vitro evaluations were performed in a similar manner as in vivo on a Braino phantom containing brain metabolites at physiological concentrations and pH.Intra- and intersubject variability were measured. Test-retest repeatability was calculated using coefficient of variation (CV), and reliability was assessed with standard error measurement (SEM) and intraclass correlation coefficient (ICC), using SPSS software.STATISTICAL TESTSIntra- and intersubject variability were measured. Test-retest repeatability was calculated using coefficient of variation (CV), and reliability was assessed with standard error measurement (SEM) and intraclass correlation coefficient (ICC), using SPSS software.The intra/inter CV for in vitro and in vivo data ranged from 0.01-0.23%/0.02-0.29% and 0.03-0.23%/0.04-0.39%, respectively. The major diagonal peaks showed ICC ranging from 0.31 to 0.93, while the ICC for cross peaks were 0.09-0.87. The SEM for in vivo data ranged from 0.0016 to 0.08. The interweek interval may have a positive effect on metabolite ratios (P = 0.08; F = 1.78).RESULTSThe intra/inter CV for in vitro and in vivo data ranged from 0.01-0.23%/0.02-0.29% and 0.03-0.23%/0.04-0.39%, respectively. The major diagonal peaks showed ICC ranging from 0.31 to 0.93, while the ICC for cross peaks were 0.09-0.87. The SEM for in vivo data ranged from 0.0016 to 0.08. The interweek interval may have a positive effect on metabolite ratios (P = 0.08; F = 1.78).The low variability in metabolite concentration in this study shows a high level of reliability of 2D L-COSY in the human brain.DATA CONCLUSIONThe low variability in metabolite concentration in this study shows a high level of reliability of 2D L-COSY in the human brain.2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:1559-1569.LEVEL OF EVIDENCE2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:1559-1569. |
| Author | Lechner‐Scott, Jeannette Ramadan, Saadallah Lea, Rod Arm, Jameen Al‐iedani, Oun Quadrelli, Scott Ribbons, Karen |
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Two‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to... Two-dimensional localized correlational spectroscopy (2D L-COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its... BACKGROUNDTwo‐dimensional localized correlational spectroscopy (2D L‐COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to... |
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| SubjectTerms | Brain Coefficient of variation Correlation analysis Correlation coefficient Correlation coefficients Cortex (cingulate) Data processing Error analysis Field strength High definition In vivo methods and tests localized correlation spectroscopy L‐COSY Magnetic resonance imaging Magnetic resonance spectroscopy Mathematical analysis Metabolites MRI MRS Neuroimaging Population (statistical) Population studies Reliability analysis repeatability Reproducibility Spectroscopy Spectrum analysis Standard error Statistical analysis Statistical tests Variability |
| Title | Reliability of neurometabolite detection with two‐dimensional localized correlation spectroscopy at 3T |
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