Investigation of patients with unclassified bleeding disorder and abnormal thrombin generation for physiological coagulation inhibitors reveals multiple abnormalities and a subset of patients with increased tissue factor pathway inhibitor activity

• Published in: International journal of laboratory hematology Vol. 42; no. 3; pp. 246 - 255
• Main Authors: MacDonald, Stephen, White, Danielle, Langdown, Jon, Downes, Kate, Thomas, Will
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2020
• Subjects: Adult; Aged; Bleeding; Blood Coagulation Disorders - blood; Blood Coagulation Factor Inhibitors - blood; Coagulation; Coagulation factors; Female; Fibrinogen; Humans; Lipoproteins - blood; Male; Middle Aged; Patients; Phenotypes; Thrombin; Thrombin - metabolism; Thrombomodulin; Tissue factor; Trypsin

Introduction We have routinely used thrombin generation to investigate patients with unclassified bleeding disorder (UBD). Aims: To investigate haemostatic abnormalities in patients with UBD that had abnormal thrombin generation on at least one occasion. Methods Investigation of 13 known UBD patient...