Long‐lasting implications of embryonic exposure to alcohol: Insights from zebrafish research
The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward mechanisms and habit formation learning that is supposed to contribute to the consumption of increasingly high and frequent amounts, ultimately leadin...
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| Published in | Developmental neurobiology (Hoboken, N.J.) Vol. 82; no. 1; pp. 29 - 40 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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01.01.2022
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| Abstract | The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward mechanisms and habit formation learning that is supposed to contribute to the consumption of increasingly high and frequent amounts, ultimately leading to addiction. In the context of fetal alcohol spectrum disorders, fetal alcohol syndrome (FAS) is a consequence of the harmful use of alcohol during pregnancy, which affects the embryonic development of the fetus. FAS can be easily reproduced in zebrafish by exposing the embryos to different concentrations of ethanol in water. In this regard, the aim of the present review is to discuss the late pathological implications in zebrafish exposed to ethanol at the embryonic stage, providing information in the context of human fetal alcoholic spectrum disorders. Experimental FAS in zebrafish is associated with impairments in the metabolic, morphological, neurochemical, behavioral, and cognitive domains. Many of the pathways that are affected by ethanol in zebrafish have at least one ortholog in humans, collaborating with the wider adoption of zebrafish in studies on alcohol disorders. In fact, zebrafish present validities required for the study of these conditions, which contributes to the use of this species in research, in addition to studies with rodents. |
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| AbstractList | The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward mechanisms and habit formation learning that is supposed to contribute to the consumption of increasingly high and frequent amounts, ultimately leading to addiction. In the context of fetal alcohol spectrum disorders, fetal alcohol syndrome (FAS) is a consequence of the harmful use of alcohol during pregnancy, which affects the embryonic development of the fetus. FAS can be easily reproduced in zebrafish by exposing the embryos to different concentrations of ethanol in water. In this regard, the aim of the present review is to discuss the late pathological implications in zebrafish exposed to ethanol at the embryonic stage, providing information in the context of human fetal alcoholic spectrum disorders. Experimental FAS in zebrafish is associated with impairments in the metabolic, morphological, neurochemical, behavioral, and cognitive domains. Many of the pathways that are affected by ethanol in zebrafish have at least one ortholog in humans, collaborating with the wider adoption of zebrafish in studies on alcohol disorders. In fact, zebrafish present validities required for the study of these conditions, which contributes to the use of this species in research, in addition to studies with rodents. Abstract The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward mechanisms and habit formation learning that is supposed to contribute to the consumption of increasingly high and frequent amounts, ultimately leading to addiction. In the context of fetal alcohol spectrum disorders, fetal alcohol syndrome (FAS) is a consequence of the harmful use of alcohol during pregnancy, which affects the embryonic development of the fetus. FAS can be easily reproduced in zebrafish by exposing the embryos to different concentrations of ethanol in water. In this regard, the aim of the present review is to discuss the late pathological implications in zebrafish exposed to ethanol at the embryonic stage, providing information in the context of human fetal alcoholic spectrum disorders. Experimental FAS in zebrafish is associated with impairments in the metabolic, morphological, neurochemical, behavioral, and cognitive domains. Many of the pathways that are affected by ethanol in zebrafish have at least one ortholog in humans, collaborating with the wider adoption of zebrafish in studies on alcohol disorders. In fact, zebrafish present validities required for the study of these conditions, which contributes to the use of this species in research, in addition to studies with rodents. |
| Author | Rico, Eduardo Pacheco Cararo, José Henrique |
| Author_xml | – sequence: 1 givenname: José Henrique surname: Cararo fullname: Cararo, José Henrique organization: University of Southern Santa Catarina – sequence: 2 givenname: Eduardo Pacheco orcidid: 0000-0003-0019-328X surname: Rico fullname: Rico, Eduardo Pacheco email: eduprico@gmail.com organization: University of Southern Santa Catarina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34687497$$D View this record in MEDLINE/PubMed |
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| Snippet | The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward... Abstract The harmful consumption of ethanol is associated with significant health problems and social burdens. This drug activates a complex network of reward... |
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| SubjectTerms | Addictions Alcohol Animals Cognitive ability Danio rerio development Embryo, Nonmammalian Embryogenesis Embryonic Development Ethanol Ethanol - toxicity Female Fetal Alcohol Spectrum Disorders - metabolism Fetal Alcohol Spectrum Disorders - psychology Fetal alcohol syndrome neurochemical nonmammalian model Pregnancy Reinforcement Zebrafish |
| Title | Long‐lasting implications of embryonic exposure to alcohol: Insights from zebrafish research |
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