High‐Throughput Scaffold System for Studying the Effect of Local Geometry and Topology on the Development and Orientation of Sprouting Blood Vessels

• Published in: Advanced functional materials Vol. 30; no. 18
• Main Authors: Szklanny, Ariel A., Debbi, Lior, Merdler, Uri, Neale, Dylan, Muñiz, Ayse, Kaplan, Ben, Guo, Shaowei, Lahann, Joerg, Levenberg, Shulamit
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.05.2020
• Subjects: Blood vessels; compartment geometry; Corners; Decisions; Endothelial cells; high throughput analysis; Hydrogels; Materials science; Muscles; Networks; Protocol (computers); Scaffolds; sprouting; tissue engineering; Topology; vascular development

Live tissues require vascular networks for cell nourishing. Mimicking the complex structure of native vascular networks in vitro requires understanding the governing factors of early tubulogenesis. Current vascularization protocols allow for spontaneous formation of vascular networks; however, there...