Genetic Effects on Carotid Intima-Media Thickness: Systematic Assessment and Meta-Analyses of Candidate Gene Polymorphisms Studied in More Than 5000 Subjects

• Published in: Circulation. Cardiovascular genetics Vol. 3; no. 1; pp. 15 - 21
• Main Authors: Paternoster, Lavinia, Martinez-Gonzalez, Nahara A., Charleton, Rebecca, Chung, Mabel, Lewis, Steff, Sudlow, Cathie L.M.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.02.2010
• Subjects: 5,10-Methylenetetrahydrofolate Reductase (FADH2) - genetics; Analysis of Variance; Apolipoproteins E - genetics; Carotid Arteries - pathology; Carotid Artery Diseases - genetics; Carotid Artery Diseases - pathology; Genotype; Humans; Nitric Oxide Synthase Type III - genetics; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic; Risk Factors; Sterol Regulatory Element Binding Protein 1 - genetics; Tunica Intima - pathology; Tunica Media - pathology; Vascular Diseases - genetics

BACKGROUND—Carotid intima-media thickness (CIMT) is highly heritable and associated with stroke and myocardial infarction, making it a promising quantitative intermediate phenotype for genetic studies of vascular disease. There have been many CIMT candidate gene association studies, but no systemati...