Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation

• Published in: Basic & clinical pharmacology & toxicology Vol. 134; no. 5; pp. 614 - 628
• Main Authors: Santos‐Silva, Thamyris, Colodete, Debora A. E., Lisboa, João Roberto Fernandes, Silva Freitas, Ícaro, Lopes, Caio Fábio Baeta, Hadera, Victor, Lima, Thaís Santos Almeida, Souza, Adriana Jesus, Gomes, Felipe V.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2024
• Subjects: astrocytes; Brain; Degradation; Disorders; Environmental effects; excitatory/inhibitory balance; Extracellular matrix; GABA interneurons oxidative stress; Glial cells; Interneurons; metalloproteinases; microglia; Nets; Neurodevelopmental disorders; Neurotoxicity; Oxidative stress; Parvalbumin; Perineuronal nets; Physiology; Reactive oxygen species; Structure-function relationships; γ-Aminobutyric acid; metalloproteinases; astrocytes; GABA interneurons oxidative stress; microglia; excitatory/inhibitory balance; extracellular matrix

The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly “neuron‐centric” paradigm. Particularly, the perineuronal nets (PNNs), a specialized net‐like structure formed by ECM aggregates, play significant roles in brain dev...