Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation

The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly “neuron‐centric” paradigm. Particularly, the perineuronal nets (PNNs), a specialized net‐like structure formed by ECM aggregates, play significant roles in brain dev...

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Published inBasic & clinical pharmacology & toxicology Vol. 134; no. 5; pp. 614 - 628
Main Authors Santos‐Silva, Thamyris, Colodete, Debora A. E., Lisboa, João Roberto Fernandes, Silva Freitas, Ícaro, Lopes, Caio Fábio Baeta, Hadera, Victor, Lima, Thaís Santos Almeida, Souza, Adriana Jesus, Gomes, Felipe V.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.05.2024
Subjects
astrocytes
Brain
Degradation
Disorders
Environmental effects
excitatory/inhibitory balance
Extracellular matrix
GABA interneurons oxidative stress
Glial cells
Interneurons
metalloproteinases
microglia
Nets
Neurodevelopmental disorders
Neurotoxicity
Oxidative stress
Parvalbumin
Perineuronal nets
Physiology
Reactive oxygen species
Structure-function relationships
γ-Aminobutyric acid
metalloproteinases
astrocytes
GABA interneurons oxidative stress
microglia
excitatory/inhibitory balance
extracellular matrix
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Abstract The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly “neuron‐centric” paradigm. Particularly, the perineuronal nets (PNNs), a specialized net‐like structure formed by ECM aggregates, play significant roles in brain development and physiology. PNNs enwrap synaptic junctions in various brain regions, precisely balancing new synaptic formation and long‐term stabilization, and are highly dynamic entities that change in response to environmental stimuli, especially during the neurodevelopmental period. They are found mainly surrounding parvalbumin (PV)‐expressing GABAergic interneurons, being proposed to promote PV interneuron maturation and protect them against oxidative stress and neurotoxic agents. This structural and functional proximity underscores the crucial role of PNNs in modulating PV interneuron function, which is critical for the excitatory/inhibitory balance and, consequently, higher‐level behaviours. This review delves into the molecular underpinnings governing PNNs formation and degradation, elucidating their functional interactions with PV interneurons. In the broader physiological context and brain‐related disorders, we also explore their intricate relationship with other molecules, such as reactive oxygen species and metalloproteinases, as well as glial cells. Additionally, we discuss potential therapeutic strategies for modulating PNNs in brain disorders.
AbstractList The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly "neuron-centric" paradigm. Particularly, the perineuronal nets (PNNs), a specialized net-like structure formed by ECM aggregates, play significant roles in brain development and physiology. PNNs enwrap synaptic junctions in various brain regions, precisely balancing new synaptic formation and long-term stabilization, and are highly dynamic entities that change in response to environmental stimuli, especially during the neurodevelopmental period. They are found mainly surrounding parvalbumin (PV)-expressing GABAergic interneurons, being proposed to promote PV interneuron maturation and protect them against oxidative stress and neurotoxic agents. This structural and functional proximity underscores the crucial role of PNNs in modulating PV interneuron function, which is critical for the excitatory/inhibitory balance and, consequently, higher-level behaviours. This review delves into the molecular underpinnings governing PNNs formation and degradation, elucidating their functional interactions with PV interneurons. In the broader physiological context and brain-related disorders, we also explore their intricate relationship with other molecules, such as reactive oxygen species and metalloproteinases, as well as glial cells. Additionally, we discuss potential therapeutic strategies for modulating PNNs in brain disorders.
Author Lisboa, João Roberto Fernandes
Lopes, Caio Fábio Baeta
Colodete, Debora A. E.
Gomes, Felipe V.
Silva Freitas, Ícaro
Santos‐Silva, Thamyris
Souza, Adriana Jesus
Hadera, Victor
Lima, Thaís Santos Almeida
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Cites_doi 10.1093/CERCOR/BHX258
10.1097/NEN.0B013E318183D003
10.1002/CNE.23468
10.1124/JPET.107.123505
10.1038/S41467‐020‐18984‐7
10.3390/IJMS22094467
10.1038/tp.2015.19
10.1126/SCIENCE.ABF5273/SUPPL_FILE/ABF5273_RIBOT_SM.PDF
10.1073/PNAS.87.14.5578
10.1038/tp.2014.128
10.1046/J.1460‐9568.1998.00221.X
10.1074/jbc.M003875200
10.1002/ALZ.12451
10.1523/JNEUROSCI.0394‐12.2012
10.3389/FNINT.2018.00003/BIBTEX
10.3389/FCELL.2021.696640
10.1016/J.BBI.2012.01.015
10.1016/0006‐8993(89)90416‐2
10.1126/SCIENCE.1214592
10.3389/FNSYN.2021.673210/FULL
10.1101/2020.01.03.894188
10.1016/J.MATBIO.2010.10.007
10.3389/FPSYT.2013.00146/BIBTEX
10.1523/JNEUROSCI.3857‐09.2010
10.1016/S0166‐2236(98)01261‐2
10.1038/S41380‐023‐02168‐Y
10.1016/J.EBIOM.2020.102919
10.1016/J.EPLEPSYRES.2017.02.021
10.1038/s41386‐020‐0778‐9
10.1074/JBC.M111.310029
10.1007/S12035‐021‐02317‐W
10.1016/J.SEMCDB.2018.09.011
10.1111/J.1460‐9568.2008.06108.X
10.1002/CNE.24132
10.1159/000110638
10.1523/ENEURO.0051‐18.2018
10.1016/j.biopsych.2013.05.007
10.1016/S0166‐2236(98)01298‐3
10.1016/J.BBRC.2020.03.030
10.1038/NN.2535
10.1371/JOURNAL.PONE.0209573
10.1002/JNR.21273
10.1523/JNEUROSCI.2228‐20.2020
10.1016/j.neuron.2017.06.028
10.3389/FNCEL.2022.1022754/BIBTEX
10.1038/SREP21563
10.1038/s41583‐019‐0196‐3
10.1523/JNEUROSCI.4998‐04.2005
10.1126/SCIENCE.1174146
10.1080/10409230290771546
10.1177/1535370221989263
10.1016/J.CELREP.2021.109313
10.1016/S0306‐4522(99)00071‐8
10.1038/s41467‐022‐29020‐1
10.1016/J.SCHRES.2019.12.015
10.18632/AGING.101256
10.1073/PNAS.0903546106
10.1093/CERCOR/BHR303
10.1073/PNAS.1300454110/‐/DCSUPPLEMENTAL
10.1007/S00018‐019‐03180‐8
10.1016/j.cell.2008.05.054
10.1038/NPP.2016.24
10.12688/F1000RESEARCH.12155.1
10.1038/nrn1787
10.1523/JNEUROSCI.0245‐16.2016
10.1038/S41380‐021‐01372‐Y
10.1111/BPH.14672
10.1016/J.TINS.2011.10.004
10.1016/J.MCN.2013.08.003
10.3389/FNEUR.2022.861843
10.1016/J.NEULET.2020.134980
10.1016/J.BBAGEN.2020.129804
10.1155/2022/1225578
10.1016/J.BRAINRESREV.2010.01.001
10.1016/J.BIOPSYCH.2014.12.026
10.3389/FNINT.2022.896400/BIBTEX
10.1038/s41380‐019‐0514‐1
10.1177/15357597211018688
10.1073/PNAS.1310158110/‐/DCSUPPLEMENTAL
10.1038/JCBFM.2014.104
10.1016/S0166‐2236(00)01892‐0
10.1016/J.SCHRES.2019.01.030
10.1016/J.NEUROSCIENCE.2012.05.055
10.3389/FCELL.2022.886527/FULL
10.3389/FNCEL.2013.00044/BIBTEX
10.1038/mp.2017.47
10.1371/JOURNAL.PONE.0016666
10.1093/SCHBUL/SBW156
10.1016/j.neuroscience.2014.07.049
10.7554/ELIFE.27345
10.1016/J.EXPNEUROL.2015.09.010
10.1196/ANNALS.1333.062
10.1016/j.neuroscience.2010.05.022
10.1038/s41467‐020‐20241‐w
10.1002/CNE.23701
10.1016/J.ISCI.2023.106342
10.1016/J.TINS.2019.04.003
10.3389/FNAGI.2016.00270/BIBTEX
10.1016/J.CELREP.2023.112788
10.1016/J.BIOPSYCH.2012.09.020
10.1523/JNEUROSCI.19‐16‐06897.1999
10.1016/J.IBNEUR.2023.01.002
10.1016/J.TINS.2014.12.005
10.1523/JNEUROSCI.2351‐16.2016
10.1186/S12915‐022‐01419‐8
10.1038/S41380‐022‐01634‐3
10.1016/J.CELREP.2021.109362
10.1016/J.PHRS.2011.05.005
10.1016/j.neuron.2013.02.011
10.1038/S41380‐019‐0393‐5
10.3389/FNSYN.2021.637549/BIBTEX
10.18632/ONCOTARGET.13420
10.1001/ARCHGENPSYCHIATRY.2009.196
10.1007/S00401‐005‐1060‐2/METRICS
10.1371/JOURNAL.PONE.0270239
10.1016/J.BIOPSYCH.2011.07.035
10.1097/00001756‐199210000‐00012
10.1523/JNEUROSCI.2140‐20.2020
10.1073/PNAS.1902680116/‐/DCSUPPLEMENTAL
10.1016/J.EXPNEUROL.2014.11.013
10.1016/J.NEUINT.2017.11.001
10.1016/S2215‐0366(19)30302‐5
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Issue 5
Keywords metalloproteinases
astrocytes
GABA interneurons oxidative stress
microglia
excitatory/inhibitory balance
extracellular matrix
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References 2015; 78
2013; 4
2010; 13
2015; 265
2019; 14
2022; 20
2020; 11
2013; 7
2020; 729
2016; 36
2022; 27
2018; 7
2018; 5
2019; 20
2013; 57
2008; 27
2019; 25
2011; 64
2016; 41
2013; 110
2012; 26
1998; 10
2012; 22
2010; 30
1992; 3
2014; 522
2020; 218
2007; 323
2018; 28
2015; 523
2005; 110
1989; 498
2010; 169
2017; 132
2012; 35
2001; 24
2011; 6
2012; 32
2007; 14
2014; 277
2023; 42
2021; 58
2016; 6
2016; 7
2019; 42
2013; 78
2013; 73
2018; 112
2013; 74
2022; 13
2005; 6
2019; 213
2020; 25
2021; 373
2022; 10
2007; 85
2008; 134
2018; 12
2016; 8
2014; 34
2022; 16
2022; 17
2022; 18
2009; 106
2019; 176
2017; 6
2021; 21
2015; 38
2021; 22
2021; 246
2017; 43
2013; 288
2020; 525
2020; 58
2017; 9
2010; 63
2005; 25
2021; 36
2010; 67
2020; 7
2012; 71
1990; 87
2023; 26
1999; 19
2019; 116
2005; 1043
2008; 67
2020; 46
1999; 92
2021; 41
2012; 218
2009; 325
2017; 525
2021; 9
2011; 334
2002; 37
2023; 14
2015; 5
2019; 76
2017; 22
1865; 2021
2011; 30
2000; 275
1998; 21
2017; 95
2021; 13
2021; 12
2022; 2022
2012; 1
2023
2020
2019; 89
2015; 274
e_1_2_12_6_1
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References_xml – volume: 13
  year: 2021
  article-title: Poly I:C activated microglia disrupt perineuronal nets and modulate synaptic balance in primary hippocampal neurons in vitro
  publication-title: Front Synaptic Neurosci
– volume: 95
  start-page: 639
  issue: 3
  year: 2017
  end-page: 655.e10
  article-title: Activity‐dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican
  publication-title: Neuron
– volume: 325
  start-page: 1258
  issue: 5945
  year: 2009
  end-page: 1261
  article-title: Perineuronal nets protect fear memories from erasure
  publication-title: Science
– volume: 9
  start-page: 1607
  issue: 6
  year: 2017
  article-title: Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
  publication-title: Aging (Albany NY)
– volume: 27
  start-page: 3192
  issue: 8
  year: 2022
  article-title: The extracellular matrix and perineuronal nets in memory
  publication-title: Mol Psychiatry
– volume: 112
  start-page: 59
  year: 2018
  end-page: 70
  article-title: Age‐dependent and region‐specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex
  publication-title: Neurochem Int
– volume: 13
  year: 2022
  article-title: Matrix metalloproteinase‐9 as an important contributor to the pathophysiology of depression
  publication-title: Front Neurol
– volume: 34
  start-page: 1270
  issue: 8
  year: 2014
  article-title: Highly energized inhibitory interneurons are a central element for information processing in cortical networks
  publication-title: J Cereb Blood Flow Metab
– volume: 246
  start-page: 1069
  issue: 9
  year: 2021
  article-title: Influence of glutamate and GABA transport on brain excitatory/inhibitory balance
  publication-title: Exp Biol Med
– volume: 169
  start-page: 1347
  issue: 3
  year: 2010
  end-page: 1363
  article-title: Neurons associated with aggrecan‐based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease
  publication-title: Neuroscience
– volume: 7
  start-page: 272
  issue: 3
  year: 2020
  article-title: Glial cells in schizophrenia: a unified hypothesis
  publication-title: Lancet Psychiatry
– volume: 525
  start-page: 1234
  issue: 5
  year: 2017
  end-page: 1249
  article-title: Molecular heterogeneity of aggrecan‐based perineuronal nets around five subclasses of parvalbumin‐expressing neurons in the mouse hippocampus
  publication-title: J Comp Neurol
– volume: 28
  start-page: 3951
  issue: 11
  year: 2018
  end-page: 3964
  article-title: Genetic reduction of matrix metalloproteinase‐9 promotes formation of perineuronal nets around parvalbumin‐expressing interneurons and normalizes auditory cortex responses in developing Fmr1 knock‐out mice
  publication-title: Cereb Cortex
– volume: 24
  start-page: 517
  issue: 9
  year: 2001
  end-page: 526
  article-title: Kv3 channels: voltage‐gated K channels designed for high‐frequency repetitive firing
  publication-title: Trends Neurosci
– volume: 25
  start-page: 2889
  issue: 11
  year: 2020
  article-title: MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients
  publication-title: Mol Psychiatry
– volume: 41
  start-page: 2206
  issue: 9
  year: 2016
  article-title: Reduced labeling of parvalbumin neurons and perineuronal nets in the dorsolateral prefrontal cortex of subjects with schizophrenia
  publication-title: Neuropsychopharmacology
– year: 2023
  article-title: Fast‐spiking parvalbumin‐positive interneurons in brain physiology and Alzheimer's disease
  publication-title: Mol Psychiatry
– volume: 78
  start-page: 396
  issue: 6
  year: 2015
  end-page: 402
  article-title: Prolonged period of cortical plasticity upon redox dysregulation in fast‐spiking interneurons
  publication-title: Biol Psychiatry
– volume: 13
  start-page: 1
  issue: 1
  year: 2022
  end-page: 14
  article-title: Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior
  publication-title: Nat Commun
– volume: 38
  start-page: 129
  issue: 3
  year: 2015
  end-page: 138
  article-title: Translating the MAM model of psychosis to humans
  publication-title: Trends Neurosci
– volume: 92
  start-page: 791
  issue: 3
  year: 1999
  end-page: 805
  article-title: Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease
  publication-title: Neuroscience
– volume: 22
  issue: 9
  year: 2021
  article-title: Beyond dopamine receptor antagonism: new targets for schizophrenia treatment and prevention
  publication-title: Int J Mol Sci
– volume: 106
  start-page: 9854
  issue: 24
  year: 2009
  end-page: 9859
  article-title: Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity
  publication-title: Proc Natl Acad Sci U S A
– volume: 43
  start-page: 592
  issue: 3
  year: 2017
  end-page: 600
  article-title: Prefrontal cortex dysfunction increases susceptibility to schizophrenia‐like changes induced by adolescent stress exposure
  publication-title: Schizophr Bull
– volume: 9
  year: 2021
  article-title: Neural tissue homeostasis and repair is regulated via CS and DS proteoglycan motifs
  publication-title: Front Cell Dev Biol
– volume: 525
  start-page: 989
  issue: 4
  year: 2020
  end-page: 996
  article-title: PGC‐1α regulate critical period plasticity via gene × environment interaction in the developmental trajectory to schizophrenia
  publication-title: Biochem Biophys Res Commun
– volume: 11
  issue: 1
  year: 2020
  article-title: Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits
  publication-title: Nat Commun
– volume: 134
  start-page: 508
  issue: 3
  year: 2008
  end-page: 520
  article-title: Experience‐dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
  publication-title: Cell
– volume: 20
  start-page: 451
  issue: 8
  year: 2019
  end-page: 465
  article-title: The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
  publication-title: Nat Rev Neurosci
– volume: 1043
  start-page: 545
  issue: 1
  year: 2005
  end-page: 552
  article-title: Oxidative stress and neurodegeneration
  publication-title: Ann N Y Acad Sci
– volume: 4
  issue: NOV
  year: 2013
  article-title: Regulating critical period plasticity: insight from the visual system to fear circuitry for therapeutic interventions
  publication-title: Front Psych
– volume: 26
  start-page: 623
  issue: 4
  year: 2012
  end-page: 634
  article-title: Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response
  publication-title: Brain Behav Immun
– volume: 22
  start-page: 2160
  issue: 9
  year: 2012
  end-page: 2170
  article-title: Experience‐dependent plasticity of the barrel cortex in mice observed with 2‐DG brain mapping and c‐Fos: effects of MMP‐9 KO
  publication-title: Cereb Cortex
– volume: 110
  start-page: 393
  issue: 4
  year: 2005
  end-page: 401
  article-title: Loss of perineuronal net N‐acetylgalactosamine in Alzheimer's disease
  publication-title: Acta Neuropathol
– volume: 89
  start-page: 125
  year: 2019
  end-page: 135
  article-title: Perineuronal nets in brain physiology and disease
  publication-title: Semin Cell Dev Biol
– volume: 37
  start-page: 375
  issue: 6
  year: 2002
  end-page: 536
  article-title: Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase‐9 (MMP‐9)
  publication-title: Crit Rev Biochem Mol Biol
– volume: 36
  issue: 2
  year: 2021
  article-title: Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence
  publication-title: Cell Rep
– volume: 42
  issue: 7
  year: 2023
  article-title: A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain
  publication-title: Cell Rep
– volume: 6
  year: 2017
  article-title: Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP‐9
  publication-title: Elife
– volume: 25
  start-page: 2566
  issue: 10
  year: 2005
  article-title: β‐Amyloid‐stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor α and NMDA receptors
  publication-title: J Neurosci
– volume: 218
  start-page: 367
  year: 2012
  end-page: 384
  article-title: Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix
  publication-title: Neuroscience
– volume: 18
  start-page: 942
  issue: 5
  year: 2022
  end-page: 954
  article-title: Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain
  publication-title: Alzheimers Dement
– volume: 176
  start-page: 3611
  issue: 18
  year: 2019
  article-title: The potential of memory enhancement through modulation of perineuronal nets
  publication-title: Br J Pharmacol
– volume: 26
  issue: 4
  year: 2023
  article-title: Selective dysfunction of fast‐spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
  publication-title: iScience
– volume: 265
  start-page: 48
  year: 2015
  end-page: 58
  article-title: Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
  publication-title: Exp Neurol
– volume: 30
  start-page: 145
  issue: 2
  year: 2011
  article-title: MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
  publication-title: Matrix Biol
– volume: 116
  start-page: 27063
  issue: 52
  year: 2019
  end-page: 27073
  article-title: Perineuronal nets protect long‐term memory by limiting activity‐dependent inhibition from parvalbumin interneurons
  publication-title: Proc Natl Acad Sci U S A
– volume: 25
  start-page: 3278
  issue: 12
  year: 2019
  end-page: 3291
  article-title: The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability
  publication-title: Mol Psychiatry
– volume: 67
  start-page: 155
  issue: 2
  year: 2010
  end-page: 166
  article-title: Extracellular matrix‐glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia
  publication-title: Arch Gen Psychiatry
– volume: 64
  start-page: 551
  issue: 6
  year: 2011
  end-page: 560
  article-title: Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases
  publication-title: Pharmacol Res
– volume: 36
  issue: 45
  year: 2016
  article-title: Casting a wide net: role of perineuronal nets in neural plasticity
  publication-title: J Neurosci
– volume: 14
  start-page: 111
  year: 2023
  article-title: Component‐specific reduction in perineuronal nets in senescence‐accelerated mouse strains
  publication-title: IBRO Neurosci Rep
– volume: 78
  start-page: 81
  issue: 1
  year: 2013
  end-page: 93
  article-title: Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
  publication-title: Neuron
– volume: 274
  start-page: 134
  year: 2015
  end-page: 144
  article-title: The hyaluronan and proteoglycan link proteins: organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity
  publication-title: Exp Neurol
– volume: 213
  start-page: 107
  year: 2019
  end-page: 113
  article-title: Stress during critical periods of development and risk for schizophrenia
  publication-title: Schizophr Res
– volume: 6
  issue: 1
  year: 2011
  article-title: Experience‐dependent plasticity and modulation of growth regulatory molecules at central synapses
  publication-title: PLoS ONE
– volume: 67
  start-page: 888
  issue: 9
  year: 2008
  end-page: 899
  article-title: Elevated matrix metalloproteinase‐9 and degradation of perineuronal nets in cerebrocortical multiple sclerosis plaques
  publication-title: J Neuropathol Exp Neurol
– volume: 35
  start-page: 57
  issue: 1
  year: 2012
  end-page: 67
  article-title: Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
  publication-title: Trends Neurosci
– volume: 6
  start-page: 877
  issue: 11
  year: 2005
  end-page: 888
  article-title: Critical period plasticity in local cortical circuits
  publication-title: Nat Rev Neurosci
– volume: 20
  issue: 1
  year: 2022
  article-title: Parvalbumin interneuron‐derived tissue‐type plasminogen activator shapes perineuronal net structure
  publication-title: BMC Biol
– volume: 110
  start-page: 12456
  issue: 30
  year: 2013
  end-page: 12461
  article-title: Very long‐term memories may be stored in the pattern of holes in the perineuronal net
  publication-title: Proc Natl Acad Sci U S A
– volume: 10
  start-page: 2129
  issue: 6
  year: 1998
  end-page: 2142
  article-title: Glutamate‐dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons
  publication-title: Eur J Neurosci
– volume: 76
  start-page: 3207
  issue: 16
  year: 2019
  article-title: MMPs in learning and memory and neuropsychiatric disorders
  publication-title: Cell Mol Life Sci
– volume: 7
  year: 2018
  article-title: Inhibitory control of the excitatory/inhibitory balance in psychiatric disorders
  publication-title: F1000Res
– year: 2020
  article-title: Restoring the pattern of proteoglycan sulphation in perineuronal nets corrects age‐related memory loss
  publication-title: bioRxiv
– volume: 275
  start-page: 38885
  issue: 49
  year: 2000
  end-page: 38890
  article-title: Brevican is degraded by matrix metalloproteinases and aggrecanase‐1 (ADAMTS4) at different sites
  publication-title: J Biol Chem
– volume: 132
  start-page: 50
  year: 2017
  article-title: Increased metalloproteinase activity in the hippocampus following status epilepticus
  publication-title: Epilepsy Res
– volume: 21
  start-page: 273
  issue: 4
  year: 2021
  article-title: Perineuronal net dynamics in the pathophysiology of epilepsy
  publication-title: Epilepsy Curr
– volume: 288
  issue: 38
  year: 2013
  article-title: Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains
  publication-title: J Biol Chem
– volume: 17
  issue: 6
  year: 2022
  article-title: Astrocyte depletion alters extracellular matrix composition in the demyelinating phase of Theiler's murine encephalomyelitis
  publication-title: PLoS ONE
– volume: 32
  start-page: 9429
  issue: 27
  year: 2012
  end-page: 9437
  article-title: Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex
  publication-title: J Neurosci
– volume: 63
  start-page: 26
  issue: 1‐2
  year: 2010
  end-page: 38
  article-title: Contributions of astrocytes to synapse formation and maturation—potential functions of the perisynaptic extracellular matrix
  publication-title: Brain Res Rev
– volume: 21
  start-page: 207
  issue: 5
  year: 1998
  end-page: 215
  article-title: Extracellular space structure revealed by diffusion analysis
  publication-title: Trends Neurosci
– volume: 3
  start-page: 869
  issue: 10
  year: 1992
  end-page: 872
  article-title: agglutinin‐labelled nets surround parvalbumin‐containing neurons
  publication-title: Neuroreport
– volume: 277
  start-page: 734
  year: 2014
  end-page: 746
  article-title: Aging somatosensory cortex displays increased density of WFA‐binding perineuronal nets associated with GAD‐negative neurons
  publication-title: Neuroscience
– volume: 27
  start-page: 1373
  issue: 6
  year: 2008
  end-page: 1390
  article-title: Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin‐R in the rat spinal cord
  publication-title: Eur J Neurosci
– volume: 57
  start-page: 10
  year: 2013
  end-page: 22
  article-title: Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum
  publication-title: Mol Cell Neurosci
– volume: 41
  start-page: 1274
  issue: 6
  year: 2021
  article-title: Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex
  publication-title: J Neurosci
– volume: 1
  start-page: 122
  issue: 2
  year: 2012
  article-title: Neuroprotection against iron‐induced cell death by perineuronal nets—an in vivo analysis of oxidative stress
  publication-title: Am J Neurodegener Dis
– volume: 7
  issue: MAR
  year: 2013
  article-title: Factors regulating microglia activation
  publication-title: Front Cell Neurosci
– volume: 58
  start-page: 3015
  issue: 7
  year: 2021
  end-page: 3030
  article-title: Neonatal rotenone administration induces psychiatric disorder‐like behavior and changes in mitochondrial biogenesis and synaptic proteins in adulthood
  publication-title: Mol Neurobiol
– volume: 12
  start-page: 1
  issue: 1
  year: 2021
  end-page: 17
  article-title: Perineuronal nets stabilize the grid cell network
  publication-title: Nat Commun
– volume: 10
  start-page: 1
  year: 2022
  article-title: Brevican, neurocan, tenascin‐C, and tenascin‐R act as important regulators of the interplay between perineuronal nets, synaptic integrity, inhibitory interneurons, and Otx2
  publication-title: Front Cell Dev Biol
– volume: 12
  year: 2018
  article-title: Structural variation of chondroitin sulfate chains contributes to the molecular heterogeneity of perineuronal nets
  publication-title: Front Integr Neurosci
– volume: 218
  start-page: 28
  year: 2020
  end-page: 35
  article-title: A conceptualized model linking matrix metalloproteinase‐9 to schizophrenia pathogenesis
  publication-title: Schizophr Res
– volume: 8
  issue: NOV
  year: 2016
  article-title: Age‐related deterioration of perineuronal nets in the primary auditory cortex of mice
  publication-title: Front Aging Neurosci
– volume: 74
  start-page: 427
  issue: 6
  year: 2013
  end-page: 435
  article-title: Developmental pattern of perineuronal nets in the human prefrontal cortex and their deficit in schizophrenia
  publication-title: Biol Psychiatry
– volume: 71
  start-page: 1006
  issue: 11
  year: 2012
  end-page: 1014
  article-title: N‐acetylcysteine normalizes neurochemical changes in the glutathione‐deficient schizophrenia mouse model during development
  publication-title: Biol Psychiatry
– volume: 16
  year: 2022
  article-title: The “loss” of perineuronal nets in Alzheimer's disease: missing or hiding in plain sight?
  publication-title: Front Integr Neurosci
– volume: 87
  start-page: 5578
  issue: 14
  year: 1990
  article-title: The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family
  publication-title: Proc Natl Acad Sci U S A
– volume: 373
  start-page: 77
  issue: 6550
  year: 2021
  end-page: 81
  article-title: Astrocytes close the mouse critical period for visual plasticity
  publication-title: Science (1979)
– volume: 334
  start-page: 1731
  issue: 6063
  year: 2011
  article-title: Fear erasure in mice requires synergy between antidepressant drugs and extinction training
  publication-title: Science
– volume: 2022
  year: 2022
  article-title: ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways
  publication-title: Oxid Med Cell Longev
– volume: 22
  start-page: 936
  issue: 7
  year: 2017
  end-page: 943
  article-title: Oxidative stress‐driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
  publication-title: Mol Psychiatry
– volume: 36
  issue: 1
  year: 2021
  article-title: Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60‐Hz light entrainment in the healthy brain
  publication-title: Cell Rep
– volume: 46
  start-page: 279
  issue: 2
  year: 2020
  end-page: 287
  article-title: Parvalbumin interneuron vulnerability and brain disorders
  publication-title: Neuropsychopharmacology
– volume: 27
  start-page: 1552
  issue: 3
  year: 2022
  article-title: Child abuse associates with increased recruitment of perineuronal nets in the ventromedial prefrontal cortex: a possible implication of oligodendrocyte progenitor cells
  publication-title: Mol Psychiatry
– volume: 30
  start-page: 2547
  issue: 7
  year: 2010
  article-title: Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors
  publication-title: J Neurosci
– volume: 5
  start-page: e525
  issue: 3
  year: 2015
  end-page: e525
  article-title: Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities
  publication-title: Transl Psychiatry
– volume: 323
  start-page: 946
  issue: 3
  year: 2007
  end-page: 953
  article-title: Chondroitin sulfate protects SH‐SY5Y cells from oxidative stress by inducing heme oxygenase‐1 via phosphatidylinositol 3‐kinase/Akt
  publication-title: J Pharmacol Exp Ther
– volume: 13
  year: 2021
  article-title: Impact of perineuronal nets on electrophysiology of parvalbumin interneurons, principal neurons, and brain oscillations: a review
  publication-title: Front Synaptic Neurosci
– volume: 85
  start-page: 2813
  issue: 13
  year: 2007
  end-page: 2823
  article-title: Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
  publication-title: J Neurosci Res
– volume: 19
  start-page: 6897
  issue: 16
  year: 1999
  article-title: Three‐dimensional relationships between hippocampal synapses and astrocytes
  publication-title: J Neurosci
– volume: 36
  start-page: 6312
  issue: 23
  year: 2016
  end-page: 6320
  article-title: Perineuronal nets suppress plasticity of excitatory synapses on CA2 pyramidal neurons
  publication-title: J Neurosci
– volume: 5
  issue: 4
  year: 2018
  article-title: A brain without brakes: reduced inhibition is associated with enhanced but dysregulated plasticity in the aged rat auditory cortex
  publication-title: eNeuro
– volume: 498
  start-page: 170
  issue: 1
  year: 1989
  end-page: 174
  article-title: Vicia villosa lectin‐positive neurones in human cerebral cortex. Loss in Alzheimer‐type dementia
  publication-title: Brain Res
– volume: 13
  start-page: 584
  issue: 5
  year: 2010
  end-page: 591
  article-title: Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
  publication-title: Nat Neurosci
– volume: 522
  start-page: 1249
  issue: 6
  year: 2014
  end-page: 1263
  article-title: Early postnatal expression and localization of matrix metalloproteinases‐2 and ‐9 during establishment of rat hippocampal synaptic circuitry
  publication-title: J Comp Neurol
– volume: 21
  start-page: 510
  issue: 12
  year: 1998
  end-page: 515
  article-title: Perineuronal nets: past and present
  publication-title: Trends Neurosci
– volume: 73
  start-page: 574
  issue: 6
  year: 2013
  end-page: 582
  article-title: Early‐life insults impair parvalbumin interneurons via oxidative stress: reversal by N‐acetylcysteine
  publication-title: Biol Psychiatry
– volume: 523
  start-page: 629
  issue: 4
  year: 2015
  end-page: 648
  article-title: Cell‐specific and developmental expression of lectican‐cleaving proteases in mouse hippocampus and neocortex
  publication-title: J Comp Neurol
– volume: 2021
  issue: 2
  year: 1865
  article-title: Hyaluronan degradation and release of a hyaluronan‐aggrecan complex from perineuronal nets in the aged mouse brain
  publication-title: Biochim Biophys Acta (BBA) ‐ General Subjects
– volume: 6
  year: 2016
  article-title: Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues
  publication-title: Sci Rep
– volume: 16
  year: 2022
  article-title: A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system
  publication-title: Front Cell Neurosci
– volume: 7
  issue: 48
  year: 2016
  article-title: Perineuronal nets in neurodegeneration
  publication-title: Oncotarget
– volume: 42
  start-page: 458
  issue: 7
  year: 2019
  end-page: 470
  article-title: Perineuronal nets: plasticity, protection, and therapeutic potential
  publication-title: Trends Neurosci
– volume: 14
  issue: 1
  year: 2019
  article-title: Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau
  publication-title: PLoS ONE
– volume: 110
  start-page: 9130
  issue: 22
  year: 2013
  end-page: 9135
  article-title: Perineuronal nets protect fast‐spiking interneurons against oxidative stress
  publication-title: Proc Natl Acad Sci U S A
– volume: 14
  start-page: 144
  issue: 3‐4
  year: 2007
  end-page: 149
  article-title: Matrix metalloproteinase‐9 is involved in the development and plasticity of retinotectal projections in rats
  publication-title: Neuroimmunomodulation
– volume: 729
  year: 2020
  article-title: Matrix metalloproteinases shape the oligodendrocyte (niche) during development and upon demyelination
  publication-title: Neurosci Lett
– volume: 58
  year: 2020
  article-title: Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
  publication-title: EBioMedicine
– volume: 41
  start-page: 972
  issue: 5
  year: 2021
  article-title: Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons
  publication-title: J Neurosci
– volume: 5
  start-page: e496
  issue: 1
  year: 2015
  end-page: e496
  article-title: Aggrecan and chondroitin‐6‐sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala
  publication-title: Transl Psychiatry
– ident: e_1_2_12_67_1
  doi: 10.1093/CERCOR/BHX258
– ident: e_1_2_12_70_1
  doi: 10.1097/NEN.0B013E318183D003
– ident: e_1_2_12_62_1
  doi: 10.1002/CNE.23468
– ident: e_1_2_12_122_1
  doi: 10.1124/JPET.107.123505
– ident: e_1_2_12_97_1
  doi: 10.1038/S41467‐020‐18984‐7
– ident: e_1_2_12_23_1
  doi: 10.3390/IJMS22094467
– ident: e_1_2_12_85_1
  doi: 10.1038/tp.2015.19
– ident: e_1_2_12_89_1
  doi: 10.1126/SCIENCE.ABF5273/SUPPL_FILE/ABF5273_RIBOT_SM.PDF
– ident: e_1_2_12_74_1
  doi: 10.1073/PNAS.87.14.5578
– ident: e_1_2_12_103_1
  doi: 10.1038/tp.2014.128
– ident: e_1_2_12_91_1
  doi: 10.1046/J.1460‐9568.1998.00221.X
– ident: e_1_2_12_76_1
  doi: 10.1074/jbc.M003875200
– ident: e_1_2_12_116_1
  doi: 10.1002/ALZ.12451
– ident: e_1_2_12_18_1
  doi: 10.1523/JNEUROSCI.0394‐12.2012
– ident: e_1_2_12_37_1
  doi: 10.3389/FNINT.2018.00003/BIBTEX
– ident: e_1_2_12_17_1
  doi: 10.3389/FCELL.2021.696640
– ident: e_1_2_12_84_1
  doi: 10.1016/J.BBI.2012.01.015
– ident: e_1_2_12_110_1
  doi: 10.1016/0006‐8993(89)90416‐2
– ident: e_1_2_12_120_1
  doi: 10.1126/SCIENCE.1214592
– ident: e_1_2_12_26_1
  doi: 10.3389/FNSYN.2021.673210/FULL
– ident: e_1_2_12_40_1
  doi: 10.1101/2020.01.03.894188
– ident: e_1_2_12_77_1
  doi: 10.1016/J.MATBIO.2010.10.007
– ident: e_1_2_12_31_1
  doi: 10.3389/FPSYT.2013.00146/BIBTEX
– ident: e_1_2_12_51_1
  doi: 10.1523/JNEUROSCI.3857‐09.2010
– ident: e_1_2_12_6_1
  doi: 10.1016/S0166‐2236(98)01261‐2
– ident: e_1_2_12_27_1
  doi: 10.1038/S41380‐023‐02168‐Y
– ident: e_1_2_12_87_1
  doi: 10.1016/J.EBIOM.2020.102919
– ident: e_1_2_12_71_1
  doi: 10.1016/J.EPLEPSYRES.2017.02.021
– ident: e_1_2_12_14_1
  doi: 10.1038/s41386‐020‐0778‐9
– ident: e_1_2_12_20_1
  doi: 10.1074/JBC.M111.310029
– ident: e_1_2_12_53_1
  doi: 10.1007/S12035‐021‐02317‐W
– ident: e_1_2_12_94_1
  doi: 10.1016/J.SEMCDB.2018.09.011
– ident: e_1_2_12_8_1
  doi: 10.1111/J.1460‐9568.2008.06108.X
– ident: e_1_2_12_36_1
  doi: 10.1002/CNE.24132
– ident: e_1_2_12_66_1
  doi: 10.1159/000110638
– ident: e_1_2_12_35_1
  doi: 10.1523/ENEURO.0051‐18.2018
– ident: e_1_2_12_106_1
  doi: 10.1016/j.biopsych.2013.05.007
– ident: e_1_2_12_2_1
  doi: 10.1016/S0166‐2236(98)01298‐3
– ident: e_1_2_12_59_1
  doi: 10.1016/J.BBRC.2020.03.030
– ident: e_1_2_12_92_1
  doi: 10.1038/NN.2535
– ident: e_1_2_12_108_1
  doi: 10.1371/JOURNAL.PONE.0209573
– ident: e_1_2_12_60_1
  doi: 10.1002/JNR.21273
– ident: e_1_2_12_119_1
  doi: 10.1523/JNEUROSCI.2228‐20.2020
– volume: 1
  start-page: 122
  issue: 2
  year: 2012
  ident: e_1_2_12_54_1
  article-title: Neuroprotection against iron‐induced cell death by perineuronal nets—an in vivo analysis of oxidative stress
  publication-title: Am J Neurodegener Dis
  contributor:
    fullname: Suttkus A
– ident: e_1_2_12_43_1
  doi: 10.1016/j.neuron.2017.06.028
– ident: e_1_2_12_96_1
  doi: 10.3389/FNCEL.2022.1022754/BIBTEX
– ident: e_1_2_12_100_1
  doi: 10.1038/SREP21563
– ident: e_1_2_12_5_1
  doi: 10.1038/s41583‐019‐0196‐3
– ident: e_1_2_12_81_1
  doi: 10.1523/JNEUROSCI.4998‐04.2005
– ident: e_1_2_12_41_1
  doi: 10.1126/SCIENCE.1174146
– ident: e_1_2_12_63_1
  doi: 10.1080/10409230290771546
– ident: e_1_2_12_24_1
  doi: 10.1177/1535370221989263
– ident: e_1_2_12_82_1
  doi: 10.1016/J.CELREP.2021.109313
– ident: e_1_2_12_109_1
  doi: 10.1016/S0306‐4522(99)00071‐8
– ident: e_1_2_12_98_1
  doi: 10.1038/s41467‐022‐29020‐1
– ident: e_1_2_12_73_1
  doi: 10.1016/J.SCHRES.2019.12.015
– ident: e_1_2_12_13_1
  doi: 10.18632/AGING.101256
– ident: e_1_2_12_49_1
  doi: 10.1073/PNAS.0903546106
– ident: e_1_2_12_65_1
  doi: 10.1093/CERCOR/BHR303
– ident: e_1_2_12_11_1
  doi: 10.1073/PNAS.1300454110/‐/DCSUPPLEMENTAL
– ident: e_1_2_12_61_1
  doi: 10.1007/S00018‐019‐03180‐8
– ident: e_1_2_12_19_1
  doi: 10.1016/j.cell.2008.05.054
– ident: e_1_2_12_105_1
  doi: 10.1038/NPP.2016.24
– ident: e_1_2_12_25_1
  doi: 10.12688/F1000RESEARCH.12155.1
– ident: e_1_2_12_12_1
  doi: 10.1038/nrn1787
– ident: e_1_2_12_10_1
  doi: 10.1523/JNEUROSCI.0245‐16.2016
– ident: e_1_2_12_99_1
  doi: 10.1038/S41380‐021‐01372‐Y
– ident: e_1_2_12_121_1
  doi: 10.1111/BPH.14672
– ident: e_1_2_12_112_1
  doi: 10.1016/J.TINS.2011.10.004
– ident: e_1_2_12_21_1
  doi: 10.1016/J.MCN.2013.08.003
– ident: e_1_2_12_72_1
  doi: 10.3389/FNEUR.2022.861843
– ident: e_1_2_12_102_1
  doi: 10.1016/J.NEULET.2020.134980
– ident: e_1_2_12_39_1
  doi: 10.1016/J.BBAGEN.2020.129804
– ident: e_1_2_12_50_1
  doi: 10.1155/2022/1225578
– ident: e_1_2_12_93_1
  doi: 10.1016/J.BRAINRESREV.2010.01.001
– ident: e_1_2_12_58_1
  doi: 10.1016/J.BIOPSYCH.2014.12.026
– ident: e_1_2_12_115_1
  doi: 10.3389/FNINT.2022.896400/BIBTEX
– ident: e_1_2_12_28_1
  doi: 10.1038/s41380‐019‐0514‐1
– ident: e_1_2_12_107_1
  doi: 10.1177/15357597211018688
– ident: e_1_2_12_45_1
  doi: 10.1073/PNAS.1310158110/‐/DCSUPPLEMENTAL
– ident: e_1_2_12_48_1
  doi: 10.1038/JCBFM.2014.104
– ident: e_1_2_12_22_1
  doi: 10.1016/S0166‐2236(00)01892‐0
– ident: e_1_2_12_30_1
  doi: 10.1016/J.SCHRES.2019.01.030
– ident: e_1_2_12_64_1
  doi: 10.1016/J.NEUROSCIENCE.2012.05.055
– ident: e_1_2_12_16_1
  doi: 10.3389/FCELL.2022.886527/FULL
– ident: e_1_2_12_80_1
  doi: 10.3389/FNCEL.2013.00044/BIBTEX
– ident: e_1_2_12_56_1
  doi: 10.1038/mp.2017.47
– ident: e_1_2_12_69_1
  doi: 10.1371/JOURNAL.PONE.0016666
– ident: e_1_2_12_29_1
  doi: 10.1093/SCHBUL/SBW156
– ident: e_1_2_12_33_1
  doi: 10.1016/j.neuroscience.2014.07.049
– ident: e_1_2_12_68_1
  doi: 10.7554/ELIFE.27345
– ident: e_1_2_12_3_1
  doi: 10.1016/J.EXPNEUROL.2015.09.010
– ident: e_1_2_12_52_1
  doi: 10.1196/ANNALS.1333.062
– ident: e_1_2_12_111_1
  doi: 10.1016/j.neuroscience.2010.05.022
– ident: e_1_2_12_47_1
  doi: 10.1038/s41467‐020‐20241‐w
– ident: e_1_2_12_78_1
  doi: 10.1002/CNE.23701
– ident: e_1_2_12_88_1
  doi: 10.1016/J.ISCI.2023.106342
– ident: e_1_2_12_4_1
  doi: 10.1016/J.TINS.2019.04.003
– ident: e_1_2_12_34_1
  doi: 10.3389/FNAGI.2016.00270/BIBTEX
– ident: e_1_2_12_7_1
  doi: 10.1016/J.CELREP.2023.112788
– ident: e_1_2_12_57_1
  doi: 10.1016/J.BIOPSYCH.2012.09.020
– ident: e_1_2_12_90_1
  doi: 10.1523/JNEUROSCI.19‐16‐06897.1999
– ident: e_1_2_12_38_1
  doi: 10.1016/J.IBNEUR.2023.01.002
– ident: e_1_2_12_114_1
  doi: 10.1016/J.TINS.2014.12.005
– ident: e_1_2_12_15_1
  doi: 10.1523/JNEUROSCI.2351‐16.2016
– ident: e_1_2_12_44_1
  doi: 10.1186/S12915‐022‐01419‐8
– ident: e_1_2_12_46_1
  doi: 10.1038/S41380‐022‐01634‐3
– ident: e_1_2_12_101_1
  doi: 10.1016/J.CELREP.2021.109362
– ident: e_1_2_12_124_1
  doi: 10.1016/J.PHRS.2011.05.005
– ident: e_1_2_12_113_1
  doi: 10.1016/j.neuron.2013.02.011
– ident: e_1_2_12_75_1
  doi: 10.1038/S41380‐019‐0393‐5
– ident: e_1_2_12_83_1
  doi: 10.3389/FNSYN.2021.637549/BIBTEX
– ident: e_1_2_12_55_1
  doi: 10.18632/ONCOTARGET.13420
– ident: e_1_2_12_104_1
  doi: 10.1001/ARCHGENPSYCHIATRY.2009.196
– ident: e_1_2_12_117_1
  doi: 10.1007/S00401‐005‐1060‐2/METRICS
– ident: e_1_2_12_95_1
  doi: 10.1371/JOURNAL.PONE.0270239
– ident: e_1_2_12_123_1
  doi: 10.1016/J.BIOPSYCH.2011.07.035
– ident: e_1_2_12_9_1
  doi: 10.1097/00001756‐199210000‐00012
– ident: e_1_2_12_86_1
  doi: 10.1523/JNEUROSCI.2140‐20.2020
– ident: e_1_2_12_42_1
  doi: 10.1073/PNAS.1902680116/‐/DCSUPPLEMENTAL
– ident: e_1_2_12_118_1
  doi: 10.1016/J.EXPNEUROL.2014.11.013
– ident: e_1_2_12_32_1
  doi: 10.1016/J.NEUINT.2017.11.001
– ident: e_1_2_12_79_1
  doi: 10.1016/S2215‐0366(19)30302‐5
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Snippet The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly “neuron‐centric”...
The brain extracellular matrix (ECM) has garnered increasing attention as a fundamental component of brain function in a predominantly "neuron-centric"...
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SubjectTerms astrocytes
Brain
Degradation
Disorders
Environmental effects
excitatory/inhibitory balance
Extracellular matrix
GABA interneurons oxidative stress
Glial cells
Interneurons
metalloproteinases
microglia
Nets
Neurodevelopmental disorders
Neurotoxicity
Oxidative stress
Parvalbumin
Perineuronal nets
Physiology
Reactive oxygen species
Structure-function relationships
γ-Aminobutyric acid
Title Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbcpt.13994
https://www.ncbi.nlm.nih.gov/pubmed/38426366
https://www.proquest.com/docview/3039096884
https://search.proquest.com/docview/2934277374
Volume 134
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