α2-Chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 41; pp. 16347 - 16352
• Main Authors: Shi, Lei, Fu, Wing-Yu, Hung, Kwok-Wang, Porchetta, Cassandra, Hall, Christine, Fu, Amy K.Y, Ip, Nancy Y
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 09.10.2007; National Acad Sciences
• Subjects: Antibodies; Biological Sciences; Brain; COS cells; Ephrins; Growth cones; Molecular interactions; Neurons; Phosphorylation; Physiological regulation; Receptors

EphA4-dependent growth cone collapse requires reorganization of actin cytoskeleton through coordinated activation of Rho family GTPases. Whereas various guanine exchange factors have recently been identified to be involved in EphA4-mediated regulation of Rho GTPases and growth cone collapse, the fun...