Using MRI to study the alterations in liver blood flow, perfusion, and oxygenation in response to physiological stress challenges: Meal, hyperoxia, and hypercapnia

• Published in: Journal of magnetic resonance imaging Vol. 49; no. 6; pp. 1577 - 1586
• Main Authors: Cox, Eleanor F., Palaniyappan, Naaventhan, Aithal, Guruprasad P., Guha, I. Neil, Francis, Susan T.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2019
• Subjects: Adult; Aged; Arteries - diagnostic imaging; Blood flow; Cirrhosis; Coefficient of variation; Feasibility studies; Female; Fibrosis - diagnostic imaging; Field strength; Food; Healthy Volunteers; Hemodynamics; Hepatic artery; Hepatic Artery - diagnostic imaging; Humans; Hypercapnia; Hypercapnia - diagnostic imaging; Hypercapnia - metabolism; Hyperoxia; Hyperoxia - diagnostic imaging; Hyperoxia - metabolism; Labeling; Liver; Liver - blood supply; Liver - diagnostic imaging; liver blood flow; Liver cirrhosis; liver perfusion; liver T2; Magnetic Resonance Imaging; Male; Mapping; meal challenge; Microscopy, Phase-Contrast; Middle Aged; Oxygen - metabolism; Oxygenation; Perfusion; Phase contrast; Portal vein; Portal Vein - diagnostic imaging; Postprandial Period; Prospective Studies; Reproducibility; Reproducibility of Results; Spin dynamics; Spin labeling; Spin Labels; Statistical analysis; Statistical tests; Stress (physiology); Veins; Veins & arteries; Velocity; Young Adult; meal challenge; liver perfusion; hyperoxia; liver T2; liver blood flow; hypercapnia

Background Noninvasive assessment of dynamic changes in liver blood flow, perfusion, and oxygenation using MRI may allow detection of subtle hemodynamic alterations in cirrhosis. Purpose To assess the feasibility of measuring dynamic liver blood flow, perfusion, and T2* alterations in response to me...