The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 41; no. 12; pp. 2818 - 2829
• Main Authors: Schwandt, Melanie L, Cortes, Carlos R, Kwako, Laura E, George, David T, Momenan, Reza, Sinha, Rajita, Grigoriadis, Dimitri E, Pich, Emilio Merlo, Leggio, Lorenzo, Heilig, Markus
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.11.2016
• Subjects: Adrenalectomy; Adrenocorticotropic Hormone - blood; Adult; Aged; Alcoholism; Alcoholism - complications; Alcoholism - diagnostic imaging; Alcoholism - drug therapy; Animals; Anxiety - diagnostic imaging; Anxiety - drug therapy; Anxiety - etiology; Azabicyclo Compounds - therapeutic use; Biomarkers; Brain research; Craving - drug effects; Disease Models, Animal; Double-Blind Method; Female; Humans; Hydrocortisone - blood; Image Processing, Computer-Assisted; Imagery (Psychotherapy); Mental depression; Middle Aged; Neurosciences; Original; Oxadiazoles - therapeutic use; Oxygen - blood; Psychiatric Status Rating Scales; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors; Retrospective Studies; Single-Blind Method; Young Adult; United States > US

Blockade of corticotropin-releasing factor receptor 1 (CRF1) suppresses stress-induced alcohol seeking in rodents, but clinical translation remains. Here, we first showed that the CRF1 antagonist verucerfont potently blocks hypothalamic-pituitary adrenal (HPA) axis activation in adrenalectomized rat...