Loading dose and efficacy of continuous or extended infusion of beta‐lactams compared with intermittent administration in patients with critical illnesses: A subgroup meta‐analysis and meta‐regression analysis

• Published in: Journal of clinical pharmacy and therapeutics Vol. 46; no. 2; pp. 424 - 432
• Main Authors: Wu, Chih‐Chien, Su, Yi‐Chia, Wu, Kuan‐Sheng, Wu, Tung‐Ho, Yang, Ching‐Shiang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2021
• Subjects: antibiotics; Clinical outcomes; Clinical trials; Drug therapy; infectious diseases; loading dose; Meta-analysis; Mortality; Patients; pharmacokinetics; Sepsis; Septic shock; pharmacokinetics; loading dose; antibiotics; infectious diseases

What is known and objective The role of continuous/extended beta‐lactam infusions (CEIs) in improving clinical outcomes among critically ill patients remains controversial. Therefore, we aimed to compare the clinical efficacy of CEI versus intermittent administration (IA) of beta‐lactams by performi...