Critical Role of Astrocyte NAD + Glycohydrolase in Myelin Injury and Regeneration

• Published in: The Journal of neuroscience Vol. 41; no. 41; pp. 8644 - 8667
• Main Authors: Langley, Monica R., Choi, Chan-Il, Peclat, Thais R., Guo, Yong, Simon, Whitney L., Yoon, Hyesook, Kleppe, Laurel, Lucchinetti, Claudia F., Chini, Claudia C. S., Chini, Eduardo N., Scarisbrick, Isobel A.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 13.10.2021
• Subjects: Adenine; ADP-ribosyl Cyclase 1 - antagonists & inhibitors; ADP-ribosyl Cyclase 1 - genetics; ADP-ribosyl Cyclase 1 - metabolism; Animals; Astrocytes; Astrocytes - metabolism; Axons; CD38 antigen; Cerebellum; Cerebellum - metabolism; Consumption; Cuprizone; Deactivation; Demyelination; Depletion; Diet; Diet, High-Fat - adverse effects; Disturbances; Experimental allergic encephalomyelitis; Gliosis; Growth factors; High fat diet; Inactivation; Inflammation; Male; Membrane Glycoproteins - antagonists & inhibitors; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple sclerosis; Myelin; Myelin Sheath - genetics; Myelin Sheath - metabolism; Myelination; NAD; NAD+ Nucleosidase - physiology; Nerve Regeneration - physiology; Nicotinamide; Nicotinamide adenine dinucleotide; Oligodendrocytes; Organ Culture Techniques; Regeneration; Remyelination - physiology; Spinal cord; Toxins; NAD; myelin; astrocyte; oligodendrocyte; CD38 multiple sclerosis

Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinamide adenine dinucleotide (NAD + )-depleting enzyme...