Lung function in children with juvenile idiopathic arthritis: A cross‐sectional analysis
Aim We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function. Methods In 49 JIA children and 70 controls lung volumes by s...
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Published in | Pediatric pulmonology Vol. 54; no. 8; pp. 1242 - 1249 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.08.2019
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Abstract | Aim
We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function.
Methods
In 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single‐breath technique were evaluated.
Results
DLCO was significantly different between JIA children and controls (P = .01), whereas no differences were found in flow expiratory volume in 1 second (FEV
1), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF
25‐75), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls (P < .001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls (P = .003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height (P = .04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration (r = −.58, P = .006; r = −.68, P = .001, respectively) was found, whereas there was no correlation between DLCO and disease activity (r = −.10; P = .51).
Conclusions
In JIA children MTX treatment seems to have a dose‐dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended. |
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AbstractList | AIMWe measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function. METHODSIn 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single-breath technique were evaluated. RESULTSDLCO was significantly different between JIA children and controls (P = .01), whereas no differences were found in flow expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF 25-75 ), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls (P < .001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls (P = .003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height (P = .04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration (r = -.58, P = .006; r = -.68, P = .001, respectively) was found, whereas there was no correlation between DLCO and disease activity (r = -.10; P = .51). CONCLUSIONSIn JIA children MTX treatment seems to have a dose-dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended. AimWe measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function.MethodsIn 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single‐breath technique were evaluated.ResultsDLCO was significantly different between JIA children and controls (P = .01), whereas no differences were found in flow expiratory volume in 1 second (FEV1), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF25‐75), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls (P < .001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls (P = .003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height (P = .04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration (r = −.58, P = .006; r = −.68, P = .001, respectively) was found, whereas there was no correlation between DLCO and disease activity (r = −.10; P = .51).ConclusionsIn JIA children MTX treatment seems to have a dose‐dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended. Aim We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function. Methods In 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single‐breath technique were evaluated. Results DLCO was significantly different between JIA children and controls (P = .01), whereas no differences were found in flow expiratory volume in 1 second (FEV 1), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF 25‐75), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls (P < .001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls (P = .003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height (P = .04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration (r = −.58, P = .006; r = −.68, P = .001, respectively) was found, whereas there was no correlation between DLCO and disease activity (r = −.10; P = .51). Conclusions In JIA children MTX treatment seems to have a dose‐dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended. We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function. In 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single-breath technique were evaluated. DLCO was significantly different between JIA children and controls (P = .01), whereas no differences were found in flow expiratory volume in 1 second (FEV ), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF ), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls (P < .001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls (P = .003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height (P = .04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration (r = -.58, P = .006; r = -.68, P = .001, respectively) was found, whereas there was no correlation between DLCO and disease activity (r = -.10; P = .51). In JIA children MTX treatment seems to have a dose-dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended. Abstract Aim We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the influence of methotrexate (MTX) treatment and disease activity on lung function. Methods In 49 JIA children and 70 controls lung volumes by spirometry and body plethysmography, and lung diffusion for carbon monoxide (DLCO) with single‐breath technique were evaluated. Results DLCO was significantly different between JIA children and controls ( P = .01), whereas no differences were found in flow expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), forced expiratory flow at 25% to 75% of FVC (FEF 25‐75 ), peak expiratory flow, total lung capacity, and residual volume. After dividing study JIA patients according to MTX treatment, a significant difference in DLCO was found among JIA patients treated with MTX and those treated with other drugs and controls ( P < .001). A significant difference in DLCO was also found among JIA patients with active disease and those with inactive disease and controls ( P = .003). Analysis of covariance showed a weak independent effect of MTX therapy on DLCO after adjusting for sex and height ( P = .04). Furthermore, a negative correlation of DLCO with MTX cumulative dose and MTX treatment duration ( r = −.58, P = .006; r = −.68, P = .001, respectively) was found, whereas there was no correlation between DLCO and disease activity ( r = −.10; P = .51). Conclusions In JIA children MTX treatment seems to have a dose‐dependent effect on lung function. For this reason in these patients, a regular assessment of lung function, especially with DLCO evaluation, is recommended. |
Author | Di Filippo, Paola Lucantoni, Marta Petrosino, Marianna I. Gasparroni, Giorgia Marsili, Manuela Attanasi, Marina Rapino, Daniele Chiarelli, Francesco Breda, Luciana Di Pillo, Sabrina |
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Cites_doi | 10.1183/09031936.05.00035205 10.1007/s00296-004-0472-y 10.1002/(SICI)1099-0496(199712)24:6<444::AID-PPUL10>3.0.CO;2-8 10.1016/S0049-0172(95)80034-4 10.1164/ajrccm.163.3.2002054 10.1002/art.34373 10.1016/S0022-3476(05)80923-0 10.1038/nrrheum.2016.175 10.1186/s12890-015-0022-2 10.1038/sj.ejcn.1601314 10.1002/art.23087 10.1034/j.1399-3003.1999.14c09.x 10.1183/09031936.93.05060733 10.1007/s002960050047 10.1136/archdischild-2014-306049 10.1001/jama.207.5.923 10.1002/ppul.1950190209 10.1378/chest.09-0444 10.1007/s40272-016-0186-0 10.1148/rg.312095160 10.1002/art.24516 10.1016/j.berh.2016.10.004 10.1007/s003930200025 10.1016/S0140-6736(07)60363-8 10.1007/s00296-010-1548-5 10.1007/s10067-005-1158-x 10.1113/expphysiol.1961.sp001525 10.1016/j.aller.2011.02.009 |
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We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the... We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the... Abstract Aim We measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and... AimWe measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the... AIMWe measured respiratory parameters in children with juvenile idiopathic arthritis (JIA) without clinical signs of respiratory involvement and assessed the... |
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SubjectTerms | Adolescent Antirheumatic Agents - therapeutic use Arthritis Arthritis, Juvenile - drug therapy Arthritis, Juvenile - physiopathology Child children Cross-Sectional Studies Female Humans juvenile idiopathic arthritis Lung - physiopathology lung diffusion for carbon monoxide lung pathology Lungs Male Methotrexate - therapeutic use Pediatrics Plethysmography, Whole Body Respiratory Function Tests Respiratory system |
Title | Lung function in children with juvenile idiopathic arthritis: A cross‐sectional analysis |
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