High expression levels of circulating microRNA‐122 and microRNA‐222 are associated with obesity in children with Mayan ethnicity
Objectives High expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR‐122 and miR‐222 and the risk of obesity was evaluated in Mexican...
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Published in | American journal of human biology Vol. 33; no. 6; pp. e23540 - n/a |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.11.2021
Wiley Subscription Services, Inc |
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Abstract | Objectives
High expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR‐122 and miR‐222 and the risk of obesity was evaluated in Mexican school‐aged children, where childhood obesity is the primary cause of morbidity.
Methods
Anthropometric data, biochemical parameters, and caloric intake were obtained in 50 children with obesity and 49 children with normal weight. The expression of circulating miR‐122 and miR‐222 was measured by quantitative real‐time polymerase chain reaction amplification. Data were analyzed using Student t test, Pearson correlation coefficient, associations with chi‐square, and multiple linear and logistic regressions with SPSS software v.23.
Results
The mean relative expression for miR‐122 and miR‐222 was 0.33 and 5.65, respectively, for children with obesity and 0.22 and 3.16, respectively, for children with normal weight. The expression of miR‐122 and miR‐222 was 1.47 and 1.78‐fold higher, respectively, in children with obesity (P = 0.001 and P = 0.025). HELs of both miR‐122 and miR‐222 were associated with body mass index (BMI), waist to height ratio (WHR), fat percentage, serum high‐density lipid levels, triglycerides (TGs), and metabolic index (MI) (P < .001).
Conclusions
The HELs of circulating miR‐122 conferred a 3.85‐fold increase in the risk for obesity, whereas the HELs of both miR‐122 and miR‐222 conferred a 3.11‐fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high‐density lipid levels, TGs, and MI, in Mayan children. |
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AbstractList | OBJECTIVESHigh expression levels (HELs) of microRNA-122 (miR-122) or microRNA-222 (miR-222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR-122 and miR-222 and the risk of obesity was evaluated in Mexican school-aged children, where childhood obesity is the primary cause of morbidity. METHODSAnthropometric data, biochemical parameters, and caloric intake were obtained in 50 children with obesity and 49 children with normal weight. The expression of circulating miR-122 and miR-222 was measured by quantitative real-time polymerase chain reaction amplification. Data were analyzed using Student t test, Pearson correlation coefficient, associations with chi-square, and multiple linear and logistic regressions with SPSS software v.23. RESULTSThe mean relative expression for miR-122 and miR-222 was 0.33 and 5.65, respectively, for children with obesity and 0.22 and 3.16, respectively, for children with normal weight. The expression of miR-122 and miR-222 was 1.47 and 1.78-fold higher, respectively, in children with obesity (P = 0.001 and P = 0.025). HELs of both miR-122 and miR-222 were associated with body mass index (BMI), waist to height ratio (WHR), fat percentage, serum high-density lipid levels, triglycerides (TGs), and metabolic index (MI) (P < .001). CONCLUSIONSThe HELs of circulating miR-122 conferred a 3.85-fold increase in the risk for obesity, whereas the HELs of both miR-122 and miR-222 conferred a 3.11-fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high-density lipid levels, TGs, and MI, in Mayan children. Abstract Objectives High expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR‐122 and miR‐222 and the risk of obesity was evaluated in Mexican school‐aged children, where childhood obesity is the primary cause of morbidity. Methods Anthropometric data, biochemical parameters, and caloric intake were obtained in 50 children with obesity and 49 children with normal weight. The expression of circulating miR‐122 and miR‐222 was measured by quantitative real‐time polymerase chain reaction amplification. Data were analyzed using Student t test, Pearson correlation coefficient, associations with chi‐square, and multiple linear and logistic regressions with SPSS software v.23. Results The mean relative expression for miR‐122 and miR‐222 was 0.33 and 5.65, respectively, for children with obesity and 0.22 and 3.16, respectively, for children with normal weight. The expression of miR‐122 and miR‐222 was 1.47 and 1.78‐fold higher, respectively, in children with obesity ( P = 0.001 and P = 0.025). HELs of both miR‐122 and miR‐222 were associated with body mass index (BMI), waist to height ratio (WHR), fat percentage, serum high‐density lipid levels, triglycerides (TGs), and metabolic index (MI) ( P < .001). Conclusions The HELs of circulating miR‐122 conferred a 3.85‐fold increase in the risk for obesity, whereas the HELs of both miR‐122 and miR‐222 conferred a 3.11‐fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high‐density lipid levels, TGs, and MI, in Mayan children. Objectives High expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR‐122 and miR‐222 and the risk of obesity was evaluated in Mexican school‐aged children, where childhood obesity is the primary cause of morbidity. Methods Anthropometric data, biochemical parameters, and caloric intake were obtained in 50 children with obesity and 49 children with normal weight. The expression of circulating miR‐122 and miR‐222 was measured by quantitative real‐time polymerase chain reaction amplification. Data were analyzed using Student t test, Pearson correlation coefficient, associations with chi‐square, and multiple linear and logistic regressions with SPSS software v.23. Results The mean relative expression for miR‐122 and miR‐222 was 0.33 and 5.65, respectively, for children with obesity and 0.22 and 3.16, respectively, for children with normal weight. The expression of miR‐122 and miR‐222 was 1.47 and 1.78‐fold higher, respectively, in children with obesity (P = 0.001 and P = 0.025). HELs of both miR‐122 and miR‐222 were associated with body mass index (BMI), waist to height ratio (WHR), fat percentage, serum high‐density lipid levels, triglycerides (TGs), and metabolic index (MI) (P < .001). Conclusions The HELs of circulating miR‐122 conferred a 3.85‐fold increase in the risk for obesity, whereas the HELs of both miR‐122 and miR‐222 conferred a 3.11‐fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high‐density lipid levels, TGs, and MI, in Mayan children. High expression levels (HELs) of microRNA-122 (miR-122) or microRNA-222 (miR-222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR-122 and miR-222 and the risk of obesity was evaluated in Mexican school-aged children, where childhood obesity is the primary cause of morbidity. Anthropometric data, biochemical parameters, and caloric intake were obtained in 50 children with obesity and 49 children with normal weight. The expression of circulating miR-122 and miR-222 was measured by quantitative real-time polymerase chain reaction amplification. Data were analyzed using Student t test, Pearson correlation coefficient, associations with chi-square, and multiple linear and logistic regressions with SPSS software v.23. The mean relative expression for miR-122 and miR-222 was 0.33 and 5.65, respectively, for children with obesity and 0.22 and 3.16, respectively, for children with normal weight. The expression of miR-122 and miR-222 was 1.47 and 1.78-fold higher, respectively, in children with obesity (P = 0.001 and P = 0.025). HELs of both miR-122 and miR-222 were associated with body mass index (BMI), waist to height ratio (WHR), fat percentage, serum high-density lipid levels, triglycerides (TGs), and metabolic index (MI) (P < .001). The HELs of circulating miR-122 conferred a 3.85-fold increase in the risk for obesity, whereas the HELs of both miR-122 and miR-222 conferred a 3.11-fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high-density lipid levels, TGs, and MI, in Mayan children. |
Author | Rubí‐Castellanos, Rodrigo Torres‐Romero, Julio César Lara‐Riegos, Julio César Pérez‐Mendoza, Gerardo José González‐Arce, Larissa Michelle González‐Herrera, Lizbeth Vega‐Marcín, Miguel Valencia‐Pacheco, Guillermo |
Author_xml | – sequence: 1 givenname: Larissa Michelle surname: González‐Arce fullname: González‐Arce, Larissa Michelle organization: Universidad Autónoma de Yucatán – sequence: 2 givenname: Julio César surname: Lara‐Riegos fullname: Lara‐Riegos, Julio César organization: Universidad Autónoma de Yucatán – sequence: 3 givenname: Gerardo José surname: Pérez‐Mendoza fullname: Pérez‐Mendoza, Gerardo José organization: Universidad Autónoma de Yucatán – sequence: 4 givenname: Rodrigo surname: Rubí‐Castellanos fullname: Rubí‐Castellanos, Rodrigo organization: Universidad Autónoma de Yucatán – sequence: 5 givenname: Miguel surname: Vega‐Marcín fullname: Vega‐Marcín, Miguel organization: Universidad Autónoma de Yucatán – sequence: 6 givenname: Guillermo surname: Valencia‐Pacheco fullname: Valencia‐Pacheco, Guillermo organization: Universidad Autónoma de Yucatán – sequence: 7 givenname: Julio César surname: Torres‐Romero fullname: Torres‐Romero, Julio César organization: Universidad Autónoma de Yucatán – sequence: 8 givenname: Lizbeth orcidid: 0000-0002-8620-3954 surname: González‐Herrera fullname: González‐Herrera, Lizbeth email: lizbeth@correo.uady.mx |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33226155$$D View this record in MEDLINE/PubMed |
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High expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which leads to... High expression levels (HELs) of microRNA-122 (miR-122) or microRNA-222 (miR-222) have been associated with insulin resistance (IR), which leads to the... Abstract Objectives High expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which... ObjectivesHigh expression levels (HELs) of microRNA‐122 (miR‐122) or microRNA‐222 (miR‐222) have been associated with insulin resistance (IR), which leads to... OBJECTIVESHigh expression levels (HELs) of microRNA-122 (miR-122) or microRNA-222 (miR-222) have been associated with insulin resistance (IR), which leads to... |
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SubjectTerms | Anthropometry Body mass Body Mass Index Body size Child Children Circulating MicroRNA Correlation coefficient Correlation coefficients Density Ethnicity Humans Insulin Insulin resistance Lipids Mexico - epidemiology MicroRNAs MicroRNAs - genetics Minority & ethnic groups miRNA Morbidity Obesity Parameters Pediatric Obesity - ethnology Pediatric Obesity - genetics Polymerase chain reaction Ribonucleic acid Risk RNA Triglycerides Weight |
Title | High expression levels of circulating microRNA‐122 and microRNA‐222 are associated with obesity in children with Mayan ethnicity |
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