Neutral polysaccharide from Panax notoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22-bearing mice

• Published in: BMC cancer Vol. 21; no. 1; pp. 37 - 13
• Main Authors: Liu, Yan-Hong, Qin, Hua-Yan, Zhong, Yuan-Yuan, Li, Shuang, Wang, Hua-Jing, Wang, Hong, Chen, Li-Ling, Tang, Xiang, Li, Ya-Lin, Qian, Zhong-Yi, Li, Huai-Yu, Zhang, Lei, Chen, Tong
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.01.2021; BMC
• Subjects: Animals; Antineoplastic Agents, Alkylating - pharmacology; Antitumor activity; Apoptosis; Bone marrow; Brain cancer; Cancer therapies; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - pathology; Cell Proliferation; Chemotherapy; Chromatography; Combined medication; Concanavalin A; Cyclophosphamide; Cyclophosphamide - pharmacology; Cytotoxicity; Deoxyribonucleic acid; DNA; Drug Synergism; Female; Hemodialysis; Hepatocellular carcinoma; Hepatocytes; Hepatoma; Humans; Humoral immunity; Immune clearance; Immune response; Immune system; Immunosuppression; Ion exchange; Laboratory animals; Life span; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - pathology; Lymphocytes; Mice; Molecular weight; Myelosuppression; Natural killer cells; Neutral polysaccharide from Panax notoginseng; Panax notoginseng; Panax notoginseng - chemistry; Plant Extracts - pharmacology; Polysaccharides; Polysaccharides - pharmacology; Purification; Reagents; Spleen; Sulfuric acid; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Beijing China; China; Panax notoginseng; Liver cancer; Immunosuppression; Purification; Neutral polysaccharide from Panax notoginseng; Myelosuppression; Combined medication

Our previous studies demonstrated that the administration of crude Polysaccharide from Panax notoginseng (CPPN) can effectively prolong the lifespan of tumor-bearing mice via boosting the host immune system as well as weak cytotoxicity against hepatocellular carcinoma (HCC). In the present study, Ne...