Determination of IgG Subclasses and Avidity of Antithyroid Peroxidase Antibodies in Patients with Subclinical Hypothyroidism – A Comparison with Patients with Overt Hypothyroidism
Objective: To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C). Methods: According to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female pat...
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| Published in | Hormone research Vol. 59; no. 3; pp. 118 - 124 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel, Switzerland
S. Karger AG
01.01.2003
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| Abstract | Objective: To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C). Methods: According to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female patients were divided into three groups (sH, H and C). IgG subclass levels and avidity were measured by a homemade ELISA. Results were analyzed by nonparametric tests and Spearman’s rank correlation. Results: The predominant IgG subclasses detected in both case groups were IgG1 and IgG4 with a significantly higher level of IgG4 in the sH group. Consequently, the IgG1/IgG4 ratio was significantly lower in sH patients. Conclusion: The higher levels of IgG4 anti-TPO reduced significantly the IgG1/IgG4 ratio in sH patients. These results permit to envisage that increasing this ratio could be useful as a positive predictive factor for the development of overt disease in such patients. |
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| AbstractList | To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C).
According to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female patients were divided into three groups (sH, H and C). IgG subclass levels and avidity were measured by a homemade ELISA. Results were analyzed by nonparametric tests and Spearman's rank correlation.
The predominant IgG subclasses detected in both case groups were IgG1 and IgG4 with a significantly higher level of IgG4 in the sH group. Consequently, the IgG1/IgG4 ratio was significantly lower in sH patients.
The higher levels of IgG4 anti-TPO reduced significantly the IgG1/IgG4 ratio in sH patients. These results permit to envisage that increasing this ratio could be useful as a positive predictive factor for the development of overt disease in such patients. Objective: To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C). Methods: According to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female patients were divided into three groups (sH, H and C). IgG subclass levels and avidity were measured by a homemade ELISA. Results were analyzed by nonparametric tests and Spearman's rank correlation. Results: The predominant IgG subclasses detected in both case groups were IgG1 and IgG4 with a significantly higher level of IgG4 in the sH group. Consequently, the IgG1/IgG4 ratio was significantly lower in sH patients. Conclusion: The higher levels of IgG4 anti-TPO reduced significantly the IgG1/IgG4 ratio in sH patients. These results permit to envisage that increasing this ratio could be useful as a positive predictive factor for the development of overt disease in such patients. Copyright © 2003 S. Karger AG, Basel [PUBLICATION ABSTRACT] Objective: To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C). Methods: According to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female patients were divided into three groups (sH, H and C). IgG subclass levels and avidity were measured by a homemade ELISA. Results were analyzed by nonparametric tests and Spearman’s rank correlation. Results: The predominant IgG subclasses detected in both case groups were IgG1 and IgG4 with a significantly higher level of IgG4 in the sH group. Consequently, the IgG1/IgG4 ratio was significantly lower in sH patients. Conclusion: The higher levels of IgG4 anti-TPO reduced significantly the IgG1/IgG4 ratio in sH patients. These results permit to envisage that increasing this ratio could be useful as a positive predictive factor for the development of overt disease in such patients. To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C).OBJECTIVETo evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a control group (C).According to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female patients were divided into three groups (sH, H and C). IgG subclass levels and avidity were measured by a homemade ELISA. Results were analyzed by nonparametric tests and Spearman's rank correlation.METHODSAccording to the TSH, fT4 and anti-TPO antibody levels, appraised by immunometric assays, 95 female patients were divided into three groups (sH, H and C). IgG subclass levels and avidity were measured by a homemade ELISA. Results were analyzed by nonparametric tests and Spearman's rank correlation.The predominant IgG subclasses detected in both case groups were IgG1 and IgG4 with a significantly higher level of IgG4 in the sH group. Consequently, the IgG1/IgG4 ratio was significantly lower in sH patients.RESULTSThe predominant IgG subclasses detected in both case groups were IgG1 and IgG4 with a significantly higher level of IgG4 in the sH group. Consequently, the IgG1/IgG4 ratio was significantly lower in sH patients.The higher levels of IgG4 anti-TPO reduced significantly the IgG1/IgG4 ratio in sH patients. These results permit to envisage that increasing this ratio could be useful as a positive predictive factor for the development of overt disease in such patients.CONCLUSIONThe higher levels of IgG4 anti-TPO reduced significantly the IgG1/IgG4 ratio in sH patients. These results permit to envisage that increasing this ratio could be useful as a positive predictive factor for the development of overt disease in such patients. |
| Author | Zanetti, C.R. Canalli, M.H.B. Chavez, J. Silva, L.M. |
| Author_xml | – sequence: 1 givenname: L.M. surname: Silva fullname: Silva, L.M. – sequence: 2 givenname: J. surname: Chavez fullname: Chavez, J. – sequence: 3 givenname: M.H.B. surname: Canalli fullname: Canalli, M.H.B. – sequence: 4 givenname: C.R. surname: Zanetti fullname: Zanetti, C.R. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12637791$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1089/10507250152039163 10.1210/jc.82.3.925 10.1210/jc.77.6.1700 10.1210/jc.82.3.771 10.1210/jc.84.6.2064 10.1210/jc.82.10.3315 |
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| Keywords | Anti-TPO Subclinical hypothyroidism Anti-TPO avidity Anti-TPO subclasses |
| Language | English |
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| References | Biondi B, Fazio S, Palmieri EA, Carella C, Panza N, Cittaadani A, Bone F, Lombardi G, Sacca L: Left ventricular diastolic dysfunction in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 1999;84:2064-2067.1037271110.1210/jc.84.6.2064 Ridgway EC, Cooper DS, Walker H, Rodbard D, Maloof F: Peripheral responses to thyroid hormone before and after L-thyroxine therapy in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 1981;53:1238-1242.7298802 Kung AW, Pang RW, Janus ED: Elevated serum lipoprotein(a) in subclinical hypothyroidism. Clin Endocrinol (Oxf) 1995;43:445-449.7586619 Samuels MH: Subclinical thyroid disease in the elderly. Thyroid 1998;8:803-813.9777754 Nordyke RA, Gilbert FI, Miyamoto LA, Fleury KA: The superiority of antimicrosomal over antithyroglobulin antibodies for detecting Hashimoto's thyroiditis. Arch Intern Med 1993;153:862-865.8466378 Parle JV, Franklin JA, Cross KW, Jones SC, Sheppard MC: Prevalence and follow-up of abnormal thyrotrophin concentrations in the elderly in the United Kingdom. Clin Endocrinol 1991;34:77-83. Baldini IM, Vita A, Mauri MC, Amodei V, Carrisi M, Bravin S, Cantalamessa L: Psychopathological and cognitive features in subclinical hypothyroidism. Prog Neuropsychopharmacol Biol Psychiatry 1997;21:925-935. Beyer IW, Karmali R, Demeester-Mirkine N, Cogan E, Fuss MJ: Serum creatine kinase levels in overt and subclinical hypothyroidism. Thyroid 1998;8:1029-1031.9848718 Bogner U, Arntz HR, Peters H, Schleusner H: Subclinical hypothyroidism and hyperlipoproteinaemia: Indiscriminate L-thyroxine treatment not justified. Acta Endocrinol 1993;128:202-206.8480467 Wilson R, Ling H, MacLean MA, Mooney J, Kinnane D, McKillop JH, Walker JJ: Thyroid antibody titre and avidity in patients with recurrent miscarriage. Fertil Steril 1999;71:558-561. Jansson R, Thompson PM, Clark F: Association between thyroid microsomal antibodies of subclass IgG1 and hypothyroidism in autoimmune postpartum thyroiditis. Clin Exp Immunol 1986;63:80.3754185 Tanis BC, Westendorp GJ, Smelt HM: Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: A re-analysis of intervention studies. Clin Endocrinol (Oxf) 1996;44:643-649.8759176 Canaris GJ, Manowitz NR, Mayor G, Ridgway EC: The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526-534.10695693 Helfand M, Redfern CC: Screening for thyroid disease: An update. Ann Intern Med 1998;129:144-158.9669977 Hedman K, Sepällä I: Recent rubella virus infection indicated by a low avidity of specific IgG. J Clin Immunol 1988;8:214-221.3292566 Goulis DG, Tsimpiris N, Delaroudis S, Maltas B, Tzoiti M, Dagilas A, Avramides A: A stapedial reflex: A biological index found to be abnormal in clinical and subclinical hypothyroidism. Thyroid 1998;8:583-587.9709911 Di Bello V, Monzani F, Giorgi D, Bertini A, Caraccio N, Valenti G, Talini E, Paterni M, Ferrannini E, Giusti C: Ultrasonic myocardial textural analysis in subclinical hypothyroidism. J Am Soc Echocardiogr 2000;13:832-840.10980086 Briones-Urbina R, Parkes AB, Bogner U, Mariotti S, Walfish PG: Increase in antimicrosomal antibody-related IgG1 and IgG4, and titers of antithyroid peroxidase antibodies, but not antibody-dependent cell-mediated cytotoxicity in post-partum thyroiditis with transient hypothyroidism. J Endocrinol Invest 1990;13:879-886.2090668 Jaechske R, Guyatt G, Gerstein H, Patterson C, Molloy W, Cook D, Harper S, Griffith L, Carbotte R: Does treatment with L-thyroxine influence healthy status in middle-aged and older adults with subclinical hypothyroidism? J Clin Endocrinol Metab Gen Intern Med 1996;11:744-749. Althaus BU, Staub JJ, Ryff A, Oberhänsli A, Stähelin HB: LDL/HDL changes in subclinical hypothyroidism: Possible risk factors for coronary heart disease. Clin Endocrinol 1988;28:157-163. Monzani F, Del Guerra P, Caraccio N, Pruneti CA, Pucci E, Luisi M: Subclinical hypothyroidism: Neurobehavioral features and beneficial effect of L-thyroxine treatment. Clin Investig 1993;71:367-371.8508006 Smallridge RC: Disclosing subclinical thyroid disease: An approach to mild laboratory abnormalities and vague or absent symptoms. Postgrad Med J 2000;107:143-146. Braverman LE: Subclinical hypothyroidism and hypothyroidism in elderly subjects: Should they be treated? J Endocrinol Invest 1999;22(suppl 10):1-3. Spencer CA, LoPresti JS, Patel A, Guttler RB, Eigen A, Shen D, Gray P, Nicoloff JT: Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab 1990;70:453-460.2105333 Kohno Y, Yamaguchi F, Saito K, Niimi H, Nishikawa T, Hosoya T: Antithyroid peroxidase antibodies in sera from healthy subjects and from patients with chronic thyroiditis: Differences in the ability to inhibit thyroid peroxidase activities. Clin Exp Immunol 1991;85:459-463.1893628 Canaris GJ, Manowitz N, Ridgeway EC: Prevalence of abnormal TSH, lipid abnormalities, and symptoms of thyroid disease: A large observational cohort (abstract). Am Thyroid Assoc 1997;244:S123. Vanderpump MPJ, Tunbridge WMG, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Hasan DM, Rodgers H, Tunbridge F, Toung ET: The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey. Clin Endocrinol 1995;43:55-68. Mariotti S, Caturegli P, Piccolo P, Barbesino G, Pinchera A: Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab 1990;71:661-669.2168432 Guo J, Jaume JC, Rapoport B, McLachlan SM: Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: Evidence for thyroid cell damage by IgG1, but not IgG4 autoantibodies. J Clin Endocrinol Metab 1997;82:925-931.906250810.1210/jc.82.3.925 Maciel LMZ, Del Corso C, Schmidt A, Iazigi N, Tavares G, Almeida Filho OC, Maciel BC: Systolic and diastolic function in patients with subclinical hypothyroidism: Effects of thyroid therapy (abstract). Am Thyroid Assoc 1997;64:S32. Monzani F, Caraccio N, Siciliano G, Manca L, Muni L, Ferrannini E: Clinical and biochemical features of muscle dysfunction in subclinical hypothyroidism. J Clin Endocrinol Metab 1997;82:3315-3318.932936010.1210/jc.82.10.3315 Tsimihodimos V, Bairaktari E, Tzallas C, Miltiadus G, Liberopoulos E, Elisaf M: The incidence of thyroid function abnormalities in patients attending an outpatient lipid clinic. Thyroid 1999;9:365-368.10319942 Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC: L-Thyroxine therapy in subclinical hypothyroidism. Ann Intern Med 1984;101:18-24.6428290 Baker BA, Ghavib H, Markovitz H: Correlation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease. Am J Med 1983;74:941-949.6687978 Bindels JG, Westendorp RG, Frolich M, Seidells J, Blocksstrat A, Smelt AHM: The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle-aged men and women: A need for case finding? Clin Endocrinol 1999;50:217-220. Kuijpens JL, De Hann-Meulmann M, Vader HL, Pop VJ, Wiersinga WM, Drexhage HA: Cell-mediated immunity and post-partum thyroid dysfunction: A possibility for the prediction of the disease? J Clin Endocrinol Metab 1998;83:1956-1966. Huber G, Mitrache C, Guglielmetti M, Huber P, Staub JJ: Predictors of overt hypothyroidism and natural course: A long-term follow-up study in impeding thyroid failure (abstract). Am Thyroid Assoc 1997;4:S2. Piza AT, Santos JL, Chaves LB, Zanetti CR: An Elisa test suitable for the detection of virus-neutralizing antibodies in serum samples from human vaccinated with either cell-culture vaccine or suckling mouse brain vaccine. Rev Inst Med Trop São Paulo 1999;41:39-43. Ayala AR, Wartofsky L: Minimally symptomatic (subclinical) hypothyroidism. Endocrinologist 1997;7:44-50. Dorizzi R, Giavarina D, Moghetti P, Castello R: Anti-TPO and antithyroglobulin antibodies or anti-TPO antibodies alone? Clin Endocrinol 1997;46:235-238. Tunbridge WMG, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Grimley Evans J, Young E, Bird T, Smith PA: The spectrum of thyroid disease in a community: The Whickham survey. Clin Endocrinol 1977;7:481-493. Danese MD, Powe NR, Sawin CT, Laadenson PW: Screening for mild thyroid failure at the periodic health examination: A decision and cost-effectiveness analysis. JAMA 1996;276:285-292.8656540 Haggerty JJ Jr, Stern RA, Mason GA, Beckwith J, Morey C, Prange AJ: Subclinical hypothyroidism: A modifiable risk factor for depression? Am J Psychiatry 1993;150:508-510.8434671 Surks MI, Chopra IJ, Mariash CN: American Thyroid Association guidelines for use of laboratory tests in thyroid disorders. JAMA 1990;263:1529-1532.2308185 Chiovato L, Bassi P, Santini F, Mammoli C, Lapi P, Carayon P, Pinchera A: Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis. J Clin Endocrinol Metab 1993;77:1700-1705.790331510.1210/jc.77.6.1700 Ayala AR, Danese MD, Ladenson PW: When to treat mild hypothyroidism. Endocrinol Metab Clin North Am 2000;29:399-415.10874537 Zulewski H, Müller B, Exer P, Miserez A, Staub JJ: Estimation of tissue hypothyroidism by a new clinical score: Evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997;82:771-776.906248010.1210/jc.82.3.771 Kohno Y, Kijima M, Yamaguchi F, Saito K, Tsuno H, Hosoya T, Niimi H: Comparison of the IgG subclass distribution of antithyroid peroxidase antibodies in healthy subjects with that in patients with chronic thyroiditis. Endocrinol J 1993;40:317-321. Dean BM, Bottazzo GF, Cudworth AG: IgG subclass distribution in organ-specific autoantibodies. The relationship to complement fixing activity. Clin Exp Immunol 1983;52:61-66.6345036 Holm G, Engwall E, Hammastrom S, Natvig JB: Antibody-induced haemolytic activity of human blood monocytes. The role of antibody class and subclass. Scand J Clin Endocrinol Metab Immunol 1974;3:173-180. Arem R, Rokey R, Kiefe C, Escalante DA, Rodriguez A: Cardiac systolic and diastolic fun ref2 ref1 ref4 ref3 ref6 ref5 |
| References_xml | – reference: Smallridge RC: Disclosing subclinical thyroid disease: An approach to mild laboratory abnormalities and vague or absent symptoms. Postgrad Med J 2000;107:143-146. – reference: Ridgway EC, Cooper DS, Walker H, Rodbard D, Maloof F: Peripheral responses to thyroid hormone before and after L-thyroxine therapy in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 1981;53:1238-1242.7298802 – reference: Chiovato L, Bassi P, Santini F, Mammoli C, Lapi P, Carayon P, Pinchera A: Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis. J Clin Endocrinol Metab 1993;77:1700-1705.790331510.1210/jc.77.6.1700 – reference: Bindels JG, Westendorp RG, Frolich M, Seidells J, Blocksstrat A, Smelt AHM: The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle-aged men and women: A need for case finding? Clin Endocrinol 1999;50:217-220. – reference: Nordyke RA, Gilbert FI, Miyamoto LA, Fleury KA: The superiority of antimicrosomal over antithyroglobulin antibodies for detecting Hashimoto's thyroiditis. Arch Intern Med 1993;153:862-865.8466378 – reference: Ayala AR, Danese MD, Ladenson PW: When to treat mild hypothyroidism. Endocrinol Metab Clin North Am 2000;29:399-415.10874537 – reference: Canaris GJ, Manowitz N, Ridgeway EC: Prevalence of abnormal TSH, lipid abnormalities, and symptoms of thyroid disease: A large observational cohort (abstract). Am Thyroid Assoc 1997;244:S123. – reference: Kohno Y, Kijima M, Yamaguchi F, Saito K, Tsuno H, Hosoya T, Niimi H: Comparison of the IgG subclass distribution of antithyroid peroxidase antibodies in healthy subjects with that in patients with chronic thyroiditis. Endocrinol J 1993;40:317-321. – reference: Holm G, Engwall E, Hammastrom S, Natvig JB: Antibody-induced haemolytic activity of human blood monocytes. The role of antibody class and subclass. Scand J Clin Endocrinol Metab Immunol 1974;3:173-180. – reference: Kohno Y, Yamaguchi F, Saito K, Niimi H, Nishikawa T, Hosoya T: Antithyroid peroxidase antibodies in sera from healthy subjects and from patients with chronic thyroiditis: Differences in the ability to inhibit thyroid peroxidase activities. Clin Exp Immunol 1991;85:459-463.1893628 – reference: Monzani F, Caraccio N, Siciliano G, Manca L, Muni L, Ferrannini E: Clinical and biochemical features of muscle dysfunction in subclinical hypothyroidism. J Clin Endocrinol Metab 1997;82:3315-3318.932936010.1210/jc.82.10.3315 – reference: Jaechske R, Guyatt G, Gerstein H, Patterson C, Molloy W, Cook D, Harper S, Griffith L, Carbotte R: Does treatment with L-thyroxine influence healthy status in middle-aged and older adults with subclinical hypothyroidism? J Clin Endocrinol Metab Gen Intern Med 1996;11:744-749. – reference: Canaris GJ, Manowitz NR, Mayor G, Ridgway EC: The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526-534.10695693 – reference: Danese MD, Powe NR, Sawin CT, Laadenson PW: Screening for mild thyroid failure at the periodic health examination: A decision and cost-effectiveness analysis. JAMA 1996;276:285-292.8656540 – reference: Piza AT, Santos JL, Chaves LB, Zanetti CR: An Elisa test suitable for the detection of virus-neutralizing antibodies in serum samples from human vaccinated with either cell-culture vaccine or suckling mouse brain vaccine. Rev Inst Med Trop São Paulo 1999;41:39-43. – reference: Baker BA, Ghavib H, Markovitz H: Correlation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease. Am J Med 1983;74:941-949.6687978 – reference: Huber G, Mitrache C, Guglielmetti M, Huber P, Staub JJ: Predictors of overt hypothyroidism and natural course: A long-term follow-up study in impeding thyroid failure (abstract). Am Thyroid Assoc 1997;4:S2. – reference: Hedman K, Sepällä I: Recent rubella virus infection indicated by a low avidity of specific IgG. J Clin Immunol 1988;8:214-221.3292566 – reference: Jansson R, Thompson PM, Clark F: Association between thyroid microsomal antibodies of subclass IgG1 and hypothyroidism in autoimmune postpartum thyroiditis. Clin Exp Immunol 1986;63:80.3754185 – reference: Kung AW, Pang RW, Janus ED: Elevated serum lipoprotein(a) in subclinical hypothyroidism. Clin Endocrinol (Oxf) 1995;43:445-449.7586619 – reference: Bogner U, Arntz HR, Peters H, Schleusner H: Subclinical hypothyroidism and hyperlipoproteinaemia: Indiscriminate L-thyroxine treatment not justified. Acta Endocrinol 1993;128:202-206.8480467 – reference: Althaus BU, Staub JJ, Ryff A, Oberhänsli A, Stähelin HB: LDL/HDL changes in subclinical hypothyroidism: Possible risk factors for coronary heart disease. Clin Endocrinol 1988;28:157-163. – reference: Guo J, Jaume JC, Rapoport B, McLachlan SM: Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: Evidence for thyroid cell damage by IgG1, but not IgG4 autoantibodies. J Clin Endocrinol Metab 1997;82:925-931.906250810.1210/jc.82.3.925 – reference: Kuijpens JL, De Hann-Meulmann M, Vader HL, Pop VJ, Wiersinga WM, Drexhage HA: Cell-mediated immunity and post-partum thyroid dysfunction: A possibility for the prediction of the disease? J Clin Endocrinol Metab 1998;83:1956-1966. – reference: Di Bello V, Monzani F, Giorgi D, Bertini A, Caraccio N, Valenti G, Talini E, Paterni M, Ferrannini E, Giusti C: Ultrasonic myocardial textural analysis in subclinical hypothyroidism. J Am Soc Echocardiogr 2000;13:832-840.10980086 – reference: Dean BM, Bottazzo GF, Cudworth AG: IgG subclass distribution in organ-specific autoantibodies. The relationship to complement fixing activity. Clin Exp Immunol 1983;52:61-66.6345036 – reference: Zulewski H, Müller B, Exer P, Miserez A, Staub JJ: Estimation of tissue hypothyroidism by a new clinical score: Evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997;82:771-776.906248010.1210/jc.82.3.771 – reference: Samuels MH: Subclinical thyroid disease in the elderly. Thyroid 1998;8:803-813.9777754 – reference: Surks MI, Chopra IJ, Mariash CN: American Thyroid Association guidelines for use of laboratory tests in thyroid disorders. JAMA 1990;263:1529-1532.2308185 – reference: Mariotti S, Caturegli P, Piccolo P, Barbesino G, Pinchera A: Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab 1990;71:661-669.2168432 – reference: Parle JV, Franklin JA, Cross KW, Jones SC, Sheppard MC: Prevalence and follow-up of abnormal thyrotrophin concentrations in the elderly in the United Kingdom. Clin Endocrinol 1991;34:77-83. – reference: Haggerty JJ Jr, Stern RA, Mason GA, Beckwith J, Morey C, Prange AJ: Subclinical hypothyroidism: A modifiable risk factor for depression? Am J Psychiatry 1993;150:508-510.8434671 – reference: Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC: L-Thyroxine therapy in subclinical hypothyroidism. Ann Intern Med 1984;101:18-24.6428290 – reference: Arem R, Rokey R, Kiefe C, Escalante DA, Rodriguez A: Cardiac systolic and diastolic function at rest and exercise in subclinical hypothyroidism: Effect of thyroid hormone therapy. Thyroid 1996;6:397-402.893666210.1089/10507250152039163 – reference: Dorizzi R, Giavarina D, Moghetti P, Castello R: Anti-TPO and antithyroglobulin antibodies or anti-TPO antibodies alone? Clin Endocrinol 1997;46:235-238. – reference: Helfand M, Redfern CC: Screening for thyroid disease: An update. Ann Intern Med 1998;129:144-158.9669977 – reference: Vanderpump MPJ, Tunbridge WMG, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Hasan DM, Rodgers H, Tunbridge F, Toung ET: The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey. Clin Endocrinol 1995;43:55-68. – reference: Wilson R, Ling H, MacLean MA, Mooney J, Kinnane D, McKillop JH, Walker JJ: Thyroid antibody titre and avidity in patients with recurrent miscarriage. Fertil Steril 1999;71:558-561. – reference: Tanis BC, Westendorp GJ, Smelt HM: Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: A re-analysis of intervention studies. Clin Endocrinol (Oxf) 1996;44:643-649.8759176 – reference: Beyer IW, Karmali R, Demeester-Mirkine N, Cogan E, Fuss MJ: Serum creatine kinase levels in overt and subclinical hypothyroidism. Thyroid 1998;8:1029-1031.9848718 – reference: Briones-Urbina R, Parkes AB, Bogner U, Mariotti S, Walfish PG: Increase in antimicrosomal antibody-related IgG1 and IgG4, and titers of antithyroid peroxidase antibodies, but not antibody-dependent cell-mediated cytotoxicity in post-partum thyroiditis with transient hypothyroidism. J Endocrinol Invest 1990;13:879-886.2090668 – reference: Maciel LMZ, Del Corso C, Schmidt A, Iazigi N, Tavares G, Almeida Filho OC, Maciel BC: Systolic and diastolic function in patients with subclinical hypothyroidism: Effects of thyroid therapy (abstract). Am Thyroid Assoc 1997;64:S32. – reference: Ayala AR, Wartofsky L: Minimally symptomatic (subclinical) hypothyroidism. Endocrinologist 1997;7:44-50. – reference: Braverman LE: Subclinical hypothyroidism and hypothyroidism in elderly subjects: Should they be treated? J Endocrinol Invest 1999;22(suppl 10):1-3. – reference: Monzani F, Del Guerra P, Caraccio N, Pruneti CA, Pucci E, Luisi M: Subclinical hypothyroidism: Neurobehavioral features and beneficial effect of L-thyroxine treatment. Clin Investig 1993;71:367-371.8508006 – reference: Tsimihodimos V, Bairaktari E, Tzallas C, Miltiadus G, Liberopoulos E, Elisaf M: The incidence of thyroid function abnormalities in patients attending an outpatient lipid clinic. Thyroid 1999;9:365-368.10319942 – reference: Spencer CA, LoPresti JS, Patel A, Guttler RB, Eigen A, Shen D, Gray P, Nicoloff JT: Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab 1990;70:453-460.2105333 – reference: Baldini IM, Vita A, Mauri MC, Amodei V, Carrisi M, Bravin S, Cantalamessa L: Psychopathological and cognitive features in subclinical hypothyroidism. Prog Neuropsychopharmacol Biol Psychiatry 1997;21:925-935. – reference: Parkes AB, Orthman S, Hall R, John R, Lazarus JH: Role of complement in the pathogenesis of postpartum thyroiditis: Relationship between complement activation and disease presentation and progression. Eur J Endocrinol 1995;133:210-215.7655646 – reference: Biondi B, Fazio S, Palmieri EA, Carella C, Panza N, Cittaadani A, Bone F, Lombardi G, Sacca L: Left ventricular diastolic dysfunction in patients with subclinical hypothyroidism. J Clin Endocrinol Metab 1999;84:2064-2067.1037271110.1210/jc.84.6.2064 – reference: Goulis DG, Tsimpiris N, Delaroudis S, Maltas B, Tzoiti M, Dagilas A, Avramides A: A stapedial reflex: A biological index found to be abnormal in clinical and subclinical hypothyroidism. Thyroid 1998;8:583-587.9709911 – reference: Tunbridge WMG, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Grimley Evans J, Young E, Bird T, Smith PA: The spectrum of thyroid disease in a community: The Whickham survey. Clin Endocrinol 1977;7:481-493. – ident: ref2 doi: 10.1089/10507250152039163 – ident: ref5 doi: 10.1210/jc.82.3.925 – ident: ref4 doi: 10.1210/jc.77.6.1700 – ident: ref6 doi: 10.1210/jc.82.3.771 – ident: ref1 doi: 10.1210/jc.84.6.2064 – ident: ref3 doi: 10.1210/jc.82.10.3315 |
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| Snippet | Objective: To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism... To evaluate the immunoglobulin G subclasses of anti-TPO and antibody avidity in patients with subclinical hypothyroidism (sH), overt hypothyroidism (H) and a... |
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| SubjectTerms | Adult Aged Antibodies, Blocking - immunology Antibody Affinity - physiology Enzyme-Linked Immunosorbent Assay Female Humans Hypothyroidism - immunology Immunoglobulin G - analysis Immunoglobulin G - classification Immunoglobulin G - immunology Iodide Peroxidase - immunology Middle Aged Original Paper Predictive Value of Tests Thyroid Function Tests Thyroiditis, Autoimmune - immunology Thyrotropin - blood Thyroxine - blood |
| Title | Determination of IgG Subclasses and Avidity of Antithyroid Peroxidase Antibodies in Patients with Subclinical Hypothyroidism – A Comparison with Patients with Overt Hypothyroidism |
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