Effects of Yulangsan polysaccharide on monoamine neurotransmitters, adenylate cyclase activity and brain-derived neurotrophic factor expression in a mouse model of depression induced by unpredictable chronic mild stress

The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide （YLSPS; 150, 300 and 600 mg/kg） for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent a...

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Published inNeural regeneration research Vol. 7; no. 3; pp. 191 - 196
Main Authors Liang, Shuang, Huang, Renbin, Lin, Xing, Huang, Jianchun, Huang, Zhongshi, Liu, Huagang
Format Journal Article
LanguageEnglish
Published India Medknow Publications & Media Pvt. Ltd 25.01.2012
Department of Pharmacology, College of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Medknow Publications & Media Pvt Ltd
Subjects
Adenosine
Antidepressants
Behavior
Brain-derived neurotrophic factor
Drug dosages
Hypotheses
Laboratory animals
Medical research
Mental depression
Neurotransmitters
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Signal transduction
单胺类神经递质
多糖
小鼠模型
抑郁症
环化
脑源性神经营养因子
腺苷酸
酶活性
United States > US
China
Chinese medicine
neural regeneration
adenylate cyclase
Yulangsan polysaccharide
brain-derived neurotrophic factor
chronic stress
monoamine neurotransmitter
anti-depressant
Online AccessGet full text
ISSN1673-5374
1876-7958
DOI10.3969/j.issn.1673-5374.2012.03.006

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Abstract The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide （YLSPS; 150, 300 and 600 mg/kg） for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS （300 and 600 mg/kg）, monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.
AbstractList Q189; The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide (YLSPS; 150, 300 and 600 mg/kg) for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS (300 and 600 mg/kg), monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.
The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide (YLSPS; 150, 300 and 600 mg/kg) for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS (300 and 600 mg/kg), monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.
The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide (YLSPS; 150, 300 and 600 mg/kg) for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS (300 and 600 mg/kg), monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.
The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide （YLSPS; 150, 300 and 600 mg/kg） for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS （300 and 600 mg/kg）, monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.
Author Shuang Liang Renbin Huang Xing Lin Jianchun Huang ZhongshiHuang Huagang Liu
AuthorAffiliation Department of Pharmacology, College of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region,China
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Keywords Chinese medicine
neural regeneration
adenylate cyclase
Yulangsan polysaccharide
brain-derived neurotrophic factor
chronic stress
monoamine neurotransmitter
anti-depressant
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Notes The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan polysaccharide （YLSPS; 150, 300 and 600 mg/kg） for 21 days, and compared with fluoxetine-treated and normal control groups. Enzyme-linked immunosorbent assay, radioimmunity and immunohistochemical staining showed that following treatment with YLSPS （300 and 600 mg/kg）, monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression were significantly elevated, and depression-like behaviors were improved. Open-field and novelty-suppressed feeding tests showed that mouse activity levels were increased and feeding latency was shortened following treatment. Our results indicate that YLSPS inhibits depression by upregulating monoamine neurotransmitters, prefrontal cortex adenylate cyclase activity and hippocampal brain-derived neurotrophic factor expression.
Yulangsan polysaccharide; anti-depressant; chronic stress; monoamine neurotransmitter; adenylate cyclase; brain-derived neurotrophic factor; Chinese medicine; neural regeneration
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Author contributions: Shuang Liang conceived and designed this study, analyzed data and wrote the manuscript. Renbin Huang was in charge of funds, revised the manuscript, provided technical support and guided the experiments. All authors conducted the experiments and evaluated the study with the blind method.
Shuang Liang, Doctor, Department of Pharmacology, College of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
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PublicationTitle_FL NEURAL REGENERATION RESEARCH
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Snippet The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan...
Q189; The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan...
The present study established a mouse model of depression induced by unpredictable chronic mild stress. The model mice were treated with Yulangsan...
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StartPage 191
SubjectTerms Adenosine
Antidepressants
Behavior
Brain-derived neurotrophic factor
Drug dosages
Hypotheses
Laboratory animals
Medical research
Mental depression
Neurotransmitters
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Signal transduction
单胺类神经递质
多糖
小鼠模型
抑郁症
环化
脑源性神经营养因子
腺苷酸
酶活性
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Title Effects of Yulangsan polysaccharide on monoamine neurotransmitters, adenylate cyclase activity and brain-derived neurotrophic factor expression in a mouse model of depression induced by unpredictable chronic mild stress
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https://www.proquest.com/docview/2382803335
https://www.proquest.com/docview/1664199954
https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e201203006
https://pubmed.ncbi.nlm.nih.gov/PMC4353113
Volume 7
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