Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 43; no. 3; pp. 655 - 664
• Main Authors: Selvaraj, Sudhakar, Walker, Chris, Arnone, Danilo, Cao, Bo, Faulkner, Paul, Cowen, Philip J, Roiser, Jonathan P, Howes, Oliver
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group 01.02.2018
• Subjects: Amygdala; Antidepressants; Anxiety; Citalopram; Emotions; Functional magnetic resonance imaging; Original; Pattern recognition; Positron emission tomography; Serotonin S1 receptors; Serotonin uptake inhibitors

A subset of patients started on a selective serotonin reuptake inhibitor (SSRI) initially experience increased anxiety, which can lead to early discontinuation before therapeutic effects are manifest. The neural basis of this early SSRI effect is not known. Presynaptic dorsal raphe neuron (DRN) 5-HT...