Quantification of paracetamol and 5-oxoproline in serum by capillary electrophoresis: Implication for clinical toxicology

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 145; pp. 616 - 620
• Main Authors: Hložek, Tomáš, Křížek, Tomáš, Tůma, Petr, Bursová, Miroslava, Coufal, Pavel, Čabala, Radomír
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 25.10.2017
• Subjects: 5-oxoproline; Acetaminophen; Acidosis; Analgesics, Non-Narcotic; Capillary electrophoresis; Electrophoresis, Capillary; Humans; Metabolic acidosis; Paracetamol; Pyrrolidonecarboxylic Acid; 5-oxoproline; Paracetamol; Capillary electrophoresis; Metabolic acidosis

•5-oxoprolinemia is underdiagnosed cause of metabolic acidosis in cases of paracetamol overdose.•Capillary electrophoresis as method for simultaneous quantification of paracetamol and 5-oxoproline in serum.•Monitoring of the incidence of 5-oxoprolinemia by the determination of both analyte levels in...