MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 19; pp. 4978 - 4993
• Main Authors: Chuang, Huai-Chia, Chang, Chih-Chi, Teng, Chiao-Fang, Hsueh, Chia-Hsin, Chiu, Li-Li, Hsu, Pu-Ming, Lee, Ming-Ching, Hsu, Chung-Ping, Chen, Yi-Rong, Liu, Yi-Chung, Lyu, Ping-Chiang, Tan, Tse-Hua
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019
• Subjects: Animals; Carcinoma, Non-Small-Cell Lung - pathology; Humans; Lung Neoplasms - pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neoplasm Invasiveness - pathology; Phosphorylation; Protein-Serine-Threonine Kinases - metabolism; ras GTPase-Activating Proteins - metabolism

Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence, however, the role of GLK in cancer recurrence remains unclear. Here, we report that transgenic GLK promotes tumor metastasis and cell migration through the scaffold protein...